Results 191 to 200 of about 66,770 (302)

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Comprehensive Review of Types, Pathophysiology, and Treatment Approaches

open access: yesBrain and Behavior, Volume 16, Issue 5, May 2026.
Chronic inflammatory demyelinating polyneuropathy is an autoimmune disorder causing demyelination, leading to distal weakness, sensory loss, and autonomic dysfunction. Immune activation triggers macrophage‐mediated myelin damage and conduction failure.
Ayesha Khan   +11 more
wiley   +1 more source

Integration Analysis of Bayesian and Machine Learning for Heterogeneity, Biomarkers, and Optimal Combination Regimens of Pucotenlimab in Solid Tumors

open access: yesCancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT The efficacy of PD‐1 inhibitor pucotenlimab (HX008) in solid tumors exhibits heterogeneity. This study integrated data from 6 clinical trials (covering gastric/gastroesophageal junction cancer, triple‐negative breast cancer, melanoma, and dMMR/MSI‐H solid tumors) using Bayesian meta‐analysis, machine learning (optimal XGBoost AUC = 0.86), and ...
Yingge He   +6 more
wiley   +1 more source

Association between anti-nephrin autoantibodies and disease activity in minimal change disease. [PDF]

open access: yesAnn Med
Guo M   +11 more
europepmc   +1 more source

PLA2R‐Positive Membranous Nephropathy and AA Amyloidosis in an Ethiopian Patient With Chronic Hepatitis B: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT The coexistence of primary phospholipase A2 receptor positive membranous nephropathy and AA amyloidosis in a patient with chronic hepatitis B is an exceedingly rare triad presenting a profound diagnostic and therapeutic challenge. A 38‐year‐old Ethiopian man with nephrotic syndrome and chronic hepatitis B had dual pathology on renal biopsy ...
Betelhem Abreham   +4 more
wiley   +1 more source

Molecular Structures and Molecular Interactions of Peptides and Proteins at Buried Interfaces Studied Using Sum Frequency Generation Vibrational Spectroscopy

open access: yesChemistry–Methods, Volume 6, Issue 5, May 2026.
This review provides a detailed record of recent advances in the field of determining protein conformation and orientation on various interfaces using sum frequency generation vibrational spectroscopy. We delve deep into how the addition of the Hamiltonian spectral matching formalism, isotope labeling, and Molecular Dynamics simulations has allowed us ...
Zahra Asif Gandhi   +2 more
wiley   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

open access: yesMedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He   +9 more
wiley   +1 more source

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