Results 91 to 100 of about 259,280 (346)

What should pediatrician know about selective IgA deficiency (update 2017)

Zdorovʹe Rebenka, 2017
The article presents analysis of the current state of selective immunoglobulin A deficiency (SIgAD) from the point of view of the world’s leading experts, based on the results of epidemiological, genetic, molecular studies with high level of evidence ...
O.L. Logvinova, M.O. Gonchar, O.P. Pomazunovska   +2 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Evaluation of Humoral Immune Function in Patients with Bronchiectasis

Iranian Journal of Allergy, Asthma and Immunology, 2008
Bronchiectasis is a chronic debilitating condition characterized by abnormal dilated thick-walled bronchi. To investigate humoral immune function in bronchiectatic patients, this study was performed.
Parviz Tabatabaie, Asghar Aghamohammadi, Setareh Mamishi, Anna Isaeian, Golnaz Heidari, Sina Abdollahzade, Pirouz Pirouzi, Nima Rezaei, Hassan Heidarnazhad, Bahram MirSaeid Ghazi, Mehdi Yeganeh, Taher Cheraghi, Hasan Abolhasani, Shiva Saghafi, Houman Alizadeh, Mohammad Reza Anaraki   +15 more
doaj  

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Prevalence of selective immunoglobulin A deficiency in healthy Turkish school children

The Turkish Journal of Pediatrics, 2011
Immunoglobulin A (IgA) deficiency is the most common primary deficiency. We aimed to define the prevalence of IgA deficiency among healthy school children in Turkey and the differences between geographical regions.
Bilkay Baştürk, Sinan Sari, Arzu Aral, Buket Dalgiç   +3 more
doaj  

CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function

Frontiers in Immunology
CD177 plays an important role in the proliferation and differentiation of myeloid lineage cells including neutrophils, myelocytes, promyelocytes, megakaryocytes, and early erythroblasts in bone marrow.
Yunfang Li, Jianming Wu, Jianming Wu
doaj   +1 more source

Health status and infections in patients with symptomatic primary and secondary immunoglobulin G (IgG) deficiencies receiving intravenous IgG replacement [PDF]

, 2020
Rudolf Weide, Roland Schnell, Christof Schardt, Michael Koenigsmann, Burkhard Otremba, Mark‐Oliver Zahn, Jan Wierecky, Ute Braun, Manfred Hensel, Martine Klausmann, Doris Fleckenstein, Peter Ehscheidt, Stefan Feiten   +12 more
openalex   +1 more source

IgG and IgM cooperate in coating of intestinal bacteria in IgA deficiency [PDF]

, 2023
Carsten Eriksen, Janne Marie Moll, Pernille Neve Myers, Ana Pinto, Niels Banhos Danneskiold‐Samsøe, Rasmus Ibsen Dehli, Lisbeth Buus Rosholm, Marlene Dalgaard, John Penders, Daisy Jonkers, Qiang Pan‐Hammarström, Lennart Hammarström, Karsten Kristiansen, Susanne Brix   +13 more
openalex   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source