Results 101 to 110 of about 252,713 (344)

Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury. [PDF]

, 2019
Acute kidney injury (AKI) can be fatal and is a well-defined risk factor for the development of chronic kidney disease. Group 2 innate lymphoid cells (ILC2s) are innate producers of type-2 cytokines and are critical regulators of homeostasis in ...
Cameron, Guy JM, Cautivo, Kelly M, Deshpande, Aniruddh V, Foster, Paul S, Hansbro, Philip M, Jiang, Simon H, Loering, Svenja, McKenzie, Andrew NJ, Molofsky, Ari B, Starkey, Malcolm R   +9 more
core   +4 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

SOME PATHOGENETIC ASPECTS OF HYPERTHROPHY AND INFLAMMATION OF PHARYNGEAL TONSILS IN CHILDREN

Медицинская иммунология, 2014
We have measured total levels of alpha-2-macroglobulin (α2-MG), its immune complexes with IgG (α2-MG-IgG), along with IL-6, IL-8, IL-10, TNFα, lactoferrin (LF) and alpha-1-antitrypsin (AT) contents in blood sera of children with verified chronic ...
V. N. Zorina, I. I. Klimova, A. C. Vyshlova, R. M. Zorina, T. G. Riabicheva, N. A. Zorin   +5 more
doaj   +1 more source

TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica. [PDF]

, 2013
Our gastrointestinal tract is a portal of entry for a number of bacteria and viruses. Thus, this tissue must develop ways to induce antigen-specific T cell and antibody responses quickly.
DePaolo, R William, Kamdar, K, Karpus, WJ, Khakpour, S, Sugiura, Y, Young, G   +5 more
core   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

CD21 deficiency in 2 siblings and frequency of the associated mutation in the Danish population

Journal of Allergy and Clinical Immunology: Global
The clinical presentation of CD21 deficiency in 2 siblings caused by a novel mutation in the CD21 gene is reported, and the frequency of this mutation in the Danish population is explored.
Thure Mors Haunstrup, MD, Kaspar René Nielsen, MD, PhD, Sys Hasslund, MD, PhD, Line Lindgreen Eriksen, PhD, Jakob T. Bay, MD, PhD, John Baech, MD, PhD, Rudi Steffensen, PhD, Lisbeth Venø Kruse, MD, PhD   +7 more
doaj   +1 more source

Duodenal intraepithelial γ/δ T cells and soluble CD8, neopterin, and β2-microglobulin in serum of IgA-deficient subjects with or without IgG subclass deficiency [PDF]

, 1993
D E Nilssen, Pål Aukrust, S S Frøland, Fredrik Müller, O. Fausa, Trond S. Halstensen, P Brandtzæg   +6 more
openalex   +1 more source

IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]

, 2014
The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S, Bulek, Katarzyna, Dubyak, George, Fitzgerald, Katherine A, Franchi, Luigi, Gulen, Muhammet F, Herjan, Tomasz, Hu, Yinling, Karin, Michael, Klinman, Dennis, Li, Xiaoxia, Martin, Bradley N, Narla, Goutham, Nuñez, Gabriel, Sato, Takashi, Thomas, James, Wang, Chenhui, Willette-Brown, Jami, Zhong, Xiao-Ping, Zhou, Hao   +19 more
core   +1 more source

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

Aging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet, F. Heath Damron, Mary Garland‐Kledzik, Emel Sen Kilic, Tracy W. Liu   +7 more
wiley   +1 more source

Inmunodeficiencia primaria combinada: Presentación de un caso Combined primary inmunodeficiency: a case report

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2001
Se reporta el caso de un niño de 6 años de edad con infecciones respiratorias y digestivas recurrentes desde los 8 meses de edad. El estudio inmunológico reveló marcada disminución de la activación linfocitaria, niveles disminuidos de subclases de IgG2 ...
Vianed Marsán Suárez, Rinaldo Villaescusa Blanco, Lázaro O del Valle Pérez, Ada A Arce Hernández, Isabel Torres Leyva, Consuelo Macías Abraham   +5 more
doaj