Results 261 to 270 of about 427,117 (288)
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Current Opinion in Rheumatology, 2003
The immune defense against extracellular pathogens is largely dependent on antibody production. Class switch recombination and somatic hypermutation shape the secondary antibody repertoire in peripheral lymphoid tissue. In the past few years, a series of primary immune deficiencies characterized by defects in these processes and collectively referred ...
GULINO AV, NOTARANGELO, Luigi Daniele
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The immune defense against extracellular pathogens is largely dependent on antibody production. Class switch recombination and somatic hypermutation shape the secondary antibody repertoire in peripheral lymphoid tissue. In the past few years, a series of primary immune deficiencies characterized by defects in these processes and collectively referred ...
GULINO AV, NOTARANGELO, Luigi Daniele
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Pediatrics, 1971
An 8½-month-old infant with absent IgM had recurrent Pseudomonas infections. IgG and IgA, but no IgM-containing plasma cells, were identified in the spleen by immunofluorescence. The spleen and lymph nodes lacked germinal centers, but Peyer's patches and the appendix were normal.
W P, Faulk +3 more
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An 8½-month-old infant with absent IgM had recurrent Pseudomonas infections. IgG and IgA, but no IgM-containing plasma cells, were identified in the spleen by immunofluorescence. The spleen and lymph nodes lacked germinal centers, but Peyer's patches and the appendix were normal.
W P, Faulk +3 more
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Current Opinion in Rheumatology, 2006
The recent elucidation of the molecular defects leading to hyper-IgM syndromes has provided considerable insight into the complex mechanisms that govern the antibody maturation in humans.The study of a large cohort of patients revealed unexpected clinical, immunological and genetic findings, which have significant implications on the molecular basis of
Anne, Durandy +2 more
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The recent elucidation of the molecular defects leading to hyper-IgM syndromes has provided considerable insight into the complex mechanisms that govern the antibody maturation in humans.The study of a large cohort of patients revealed unexpected clinical, immunological and genetic findings, which have significant implications on the molecular basis of
Anne, Durandy +2 more
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Human IgM Anti‐IgM Cytotoxin for B Lymphocytes
Tissue Antigens, 1980Blymphocytes were shown previously to be killed at 5*C by some autologous and allogeneic human sera. We show here that such cold cytotoxins are directed against immunoglobulins on the surface of B lymphocytes. The activity is partially removed by passing serum through IgG‐coupled Sepharose and usually completely removed by passing serum through IgM ...
J C, Cicciarelli +4 more
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Scandinavian Journal of Immunology, 1973
In human sera showing elevated levels of IgM, the serum agglutinators may be of both IgG and IgM classes. When the quantity of IgG is very low, these antibodies may be solely of the IgM class. Elevations in IgM levels subsequent to loss of IgG through the kidney, as in nephrosis, and elevations in all immunoglobulin levels, as observed in severe ...
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In human sera showing elevated levels of IgM, the serum agglutinators may be of both IgG and IgM classes. When the quantity of IgG is very low, these antibodies may be solely of the IgM class. Elevations in IgM levels subsequent to loss of IgG through the kidney, as in nephrosis, and elevations in all immunoglobulin levels, as observed in severe ...
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2017
Natural IgM autoantibodies (IgM-NAA) are rapidly produced to inhibit pathogens and abrogate inflammation mediated by invading microorganisms and host neoantigens. IgM-NAA achieve this difficult task by being polyreactive with low binding affinity but with high avidity, characteristics that allow these antibodies to bind antigenic determinants shared by
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Natural IgM autoantibodies (IgM-NAA) are rapidly produced to inhibit pathogens and abrogate inflammation mediated by invading microorganisms and host neoantigens. IgM-NAA achieve this difficult task by being polyreactive with low binding affinity but with high avidity, characteristics that allow these antibodies to bind antigenic determinants shared by
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IgM paraproteinaemic neuropathies
Current Opinion in Neurology, 2004To conduct a critical review of recent studies on the pathogenesis and treatment of IgM paraproteinaemic neuropathies and analyse their implication for patient management.A better definition and classification of IgM monoclonal gammopathies has led to recommendations on therapeutic strategies for these patients, particularly for those with the ...
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Bollettino dell'Istituto sieroterapico milanese, 1986
The traditional IgM-ELISA has a better sensibility and specificity than IgM-IFA when these two tests are performed on whole sera, but in many cases (sera titer values of greater than 200 I.U./ml) the presence of IgM antitoxoplasma antibodies can be detected only after purification of IgM fractions.
FILICE, GAETANO +6 more
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The traditional IgM-ELISA has a better sensibility and specificity than IgM-IFA when these two tests are performed on whole sera, but in many cases (sera titer values of greater than 200 I.U./ml) the presence of IgM antitoxoplasma antibodies can be detected only after purification of IgM fractions.
FILICE, GAETANO +6 more
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Immunology Today, 1994
There has been a universal tendency to regard IgM antibodies as pentameric molecules comprising five immunoglobulin monomeric subunits joined by a single J-chain protein. Is this the only form of secreted IgM, or are the possibilities more complex? In this article, Joseph Brewer and colleagues propose that the IgM polymers secreted in primary immune ...
J W, Brewer +3 more
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There has been a universal tendency to regard IgM antibodies as pentameric molecules comprising five immunoglobulin monomeric subunits joined by a single J-chain protein. Is this the only form of secreted IgM, or are the possibilities more complex? In this article, Joseph Brewer and colleagues propose that the IgM polymers secreted in primary immune ...
J W, Brewer +3 more
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Circulating heavy IgM in IgM nephropathy.
Clinical and experimental immunology, 1989IgM nephropathy (IgMN) causes nephrotic syndrome and is characterized by IgM mesangial deposits. It is speculated that these deposits are derived from circulating IgM aggregates or immune complexes, either of which would have a molecular weight heavier than that of normal IgM.
S O, Disciullo +3 more
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