Results 71 to 80 of about 326,312 (327)

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Effect of fuel-air mixture dilution on knock intensity

Nihon Kikai Gakkai ronbunshu, 2016
Effect of fuel-air mixture diluted by inert gas on knock intensity was investigated by using a rapid compression and expansion machine. Dilution of fuel-air mixture decreased knock intensity.
Mitsuaki OHTOMO, Seiji YAMAMOTO, Hiroshi MIYAGAWA   +2 more
doaj   +1 more source

Multifunctional Tailoring of Fertilizer Composites Directly Derived From Phosphate Rock

Advanced Science, EarlyView.
A novel phosphorus‑sulfur mixed acid with urea (PSU) activation system converts low‑grade phosphate rock (LPR) into multifunctional fertilizer composites (MFCs). MFCs feature porous structures, high nutrient‑activation efficiency, superior slow‑release, and enhanced crop growth, offering a sustainable solution for integrated nutrient management and ...
Zenglian Qi, Jianchao Wang, Lulu Chen, Zhenya Lu, Guodong Wang, Hang Ma, Cuihong Hou, Xinxin Wang, Wenqi Ma, Changzhou Wei, Jianbo Shen, Fusuo Zhang, Minghao Zhuang, Chengdong Huang   +13 more
wiley   +1 more source

Towards the Development of a Probabilistic Approach to Informal Settlement Fire Spread Using Ignition Modelling and Spatial Metrics

Fire, 2020
Large conflagrations of informal settlements occur regularly, leaving thousands of people homeless daily and taking tens of thousands of lives annually.
Antonio Cicione, Lesley Gibson, Colleen Wade, Michael Spearpoint, Richard Walls, David Rush   +5 more
doaj   +1 more source

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

Origins of Graphite Resistivity: Decoupling Stacking Fault and Rotational Misorientation

Advanced Science, EarlyView.
Interfacial dislocations critically influence interlayer transport in van der Waals (vdW) materials, yet quantifying their individual contributions remains challenging. We measure graphite's c‐axis resistivity and develop a decoupling strategy, revealing a resistivity ratio of ∼4507:74:1 for rotational misorientations, stacking faults, and AB stacking,
Weipeng Chen, Fuwei Yang, Tielin Wu, Yelingyi Wang, Quanshui Zheng, Deli Peng, Zhanghui Wu   +6 more
wiley   +1 more source

Lightning-Induced Wildfires: An Overview

Fire
Wildfire causes environmental, economic, and human problems or losses. This study reviewed wildfires induced by lightning strikes. This review focuses on the investigations of lightning mechanisms in the laboratory.
Yang Song, Cangsu Xu, Xiaolu Li, Francis Oppong   +3 more
doaj   +1 more source

Pyrotechnic mixtures for production of gas generator charges for Base Bleed projectiles based on ascorbic acid as an organic fuel [PDF]

Scientific Technical Review, 2016
Influence of the composition of pyrotechnic mixtures based on organic fuel (ascorbic acid) on the burn rate, heat of combustion and ignition temperature was examined.
Petković-Cvetković Jelena, Milović Vladimir, Pašagić Siniša, Simić Danica, Jelisavac Ljiljana, Nešić Jovica   +5 more
doaj  

The Impact of Roaming Radicals on the Combustion Properties of Transportation Fuels

, 2017
A systematic investigation on the effects of roaming radical reactions on global combustion properties for transportation fuels is presented. New software was developed that can automatically discover all the possible roaming pathways within a given ...
Goldsmith, C. Franklin, West, Richard H.
core   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source