Results 41 to 50 of about 135,085 (243)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

FKB327, an adalimumab biosimilar, versus the reference product: results of a randomized, Phase III, double-blind study, and its open-label extension

Arthritis Research & Therapy, 2019
Objective To compare the efficacy, serum drug concentrations, immunogenicity, and safety of FKB327 with the adalimumab reference product (RP) in combination with methotrexate in patients with moderate-to-severe, active rheumatoid arthritis (RA).
Mark C. Genovese, Josephine Glover, Maria Greenwald, Wieslawa Porawska, Elias Chalouhi El Khouri, Eva Dokoupilova, Juan Ignacio Vargas, Mykola Stanislavchuk, Herbert Kellner, Elena Baranova, Nobuhito Matsunaga, Rieke Alten   +11 more
doaj   +1 more source

Poglądy Juliusza Makarewicza na niektóre problemy społeczno-ustrojowe II Rzeczypospolitej

Czasopismo Prawno-Historyczne, 1983
I. Uwagi wstępne. II. Poglądy J. Makarewicza na rolę i znaczenie warstwy inteligenckiej w funkcjonowaniu państwa. III. Ocena politycznej roli chłopstwa. IV. Poglądy dotyczące pozycji społecznej i ekonomicznej robotników. V. Poglądy J.
Marek Wąsowicz
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Państwo prawne w Konstytucji z 17 marca 1921 r.

Czasopismo Prawno-Historyczne, 1987
I. Koncepcja państwa prawnego. II. Model państwa prawnego w Konstytucji z 17 marca 1921 r. 1. Uchwalenie Konstytucji. 2. Rola i funkcje Konstytucji w systemie prawnym. 3. Zwierzchnictwo narodu. 4. Podział władzy. 5. Rola ustawy. 6. Niezawisłość sędziów.
Michał Pietrzak
doaj   +1 more source

Podstawy prawne skarbowości samorządowej w II RP

Prawo Budżetowe Państwa i Samorządu, 2013
The author of the article presents the legal basis of the treasury system of the local government during the period of so called Second Republic of Poland (1918–1939) i.e. “interwar period”. The author indicates a discrepancy between systems of the former Russian, Prussian and Austrian districts, aside from the autonomous Silesian Voivodeship created ...
openaire   +4 more sources

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Prawne zasady użytkowania pojazdów mechanicznych w Drugiej Rzeczypospolitej

Czasopismo Prawno-Historyczne, 2011
Regulacje prawne dotyczące szeroko pojętego użytkowania pojazdów mechanicznych w okresie międzywojennym należą do problematyki niezwykle ciekawej. Warto jednak podkreślić, że mimo stosunkowo licznych unormowań we wspomnianym zakresie dokonanych już w ...
Magdalena Pyter
doaj   +1 more source

Exploring Patients’ Profiles Associated With the Resolution of Acute Calcium Pyrophosphate Arthritis Treated With Colchicine and Prednisone: Post Hoc Analysis of a Randomized Controlled Trial

Arthritis Care &Research, EarlyView.
Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart, Laurène Norberciak, Pascal Richette, Pierre Robinet, Aurore Pacaud, Gauthier Marchasson, Thibault Rabin, Hélène Luraschi, Pierre Maciejasz, Anne‐France Georgel, Augustin Latourte, Hang‐Korng Ea, Sébastien Ottaviani, Charlotte Jauffret, Vincent Ducoulombier   +14 more
wiley   +1 more source

Best Polynomial Approximation in -Norm and -Growth of Entire Functions

Abstract and Applied Analysis, 2013
The classical growth has been characterized in terms of approximation errors for a continuous function on by Reddy (1970), and a compact of positive capacity by Nguyen (1982) and Winiarski (1970) with respect to the maximum norm.
Mohamed El Kadiri, Mohammed Harfaoui
doaj   +1 more source