Results 41 to 50 of about 138,967 (278)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

O sędziach pokoju w pracach Komisji Kodyfikacyjnej II RP

, 2021
The article presents work on the unification of the Polish judiciary in the Second Republic in the years 1918-1928. It was carried out in three tracks.  The initiator of the first moves consisting in unification of district regulations ...
Mohyluk, Mariusz
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Exploitation of a Medium-Sized Fuzzy Outranking Relation Based on Multi-objective Evolutionary Algorithms to Derive a Ranking

International Journal of Computational Intelligence Systems, 2016
We present a multi-objective evolutionary algorithm to exploit a medium-sized fuzzy outranking relation to derive a partial order of classes of alternatives (we call it RP-NSGA-II).
Juan Carlos Leyva López, Jesús Jaime Solano Noriega, Jorge Luis García Alcaraz, Diego Alonso Gastélum Chavira   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Poglądy Juliusza Makarewicza na niektóre problemy społeczno-ustrojowe II Rzeczypospolitej

Czasopismo Prawno-Historyczne, 1983
I. Uwagi wstępne. II. Poglądy J. Makarewicza na rolę i znaczenie warstwy inteligenckiej w funkcjonowaniu państwa. III. Ocena politycznej roli chłopstwa. IV. Poglądy dotyczące pozycji społecznej i ekonomicznej robotników. V. Poglądy J.
Marek Wąsowicz
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Państwo prawne w Konstytucji z 17 marca 1921 r.

Czasopismo Prawno-Historyczne, 1987
I. Koncepcja państwa prawnego. II. Model państwa prawnego w Konstytucji z 17 marca 1921 r. 1. Uchwalenie Konstytucji. 2. Rola i funkcje Konstytucji w systemie prawnym. 3. Zwierzchnictwo narodu. 4. Podział władzy. 5. Rola ustawy. 6. Niezawisłość sędziów.
Michał Pietrzak
doaj   +1 more source

Założenia i koncepcja kodyfikacji prawa w II RP

PRAWO i WIĘŹ, 2023
Autor przedstawia Komisję Kodyfikacyjnej II Rzeczypospolitej, która była symbolem idei przygotowania własnego, polskiego ustawodawstwa. Koncentruje się on następnie na ideowych i doktrynalnych podstawach kodyfikacji prawa prywatnego (cywilnego i handlowego) oraz karnego w Europie w XIX i XX wieku, stanowiących pewien wzorzec, przejaw dążenia do ...
openaire   +1 more source