Results 61 to 70 of about 5,995,465 (357)
On two conjectures concerning convex curves
, 2005 We recall two basic conjectures on the developables of convex projective curves, prove one of them and disprove the other in the firdt nontrivial case of curves in RP^3.
Sedykh, V., Shapiro, B.
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
International Journal of Computational Intelligence Systems, 2016 We present a multi-objective evolutionary algorithm to exploit a medium-sized fuzzy outranking relation to derive a partial order of classes of alternatives (we call it RP-NSGA-II).
Juan Carlos Leyva López +3 more
doaj +1 more source
Penentuan Jumlah Pesanan Ekonomis Persediaan Vaksin Meningitis Menveo pada Kantor Kesehatan Pelabuhan (Kkp) Kelas II Samarinda [PDF]
, 2015 This research aims to know the number of orders that are economical on The Kantor Kesehatan Pelabuhan (KKP) Kelas II Samarinda for Menveo Meningitis Vaccine and also to know the magnitude of the economic order quantity of Menveo meningitis vaccine for ...
-, N. (Nurhidayati)
core +1 more source
Journal of Orthopaedics and Traumatology, 2018 BackgroundWe compared the midterm results after total knee arthroplasty (TKA) using PFC Sigma RP-F mobile model with PFC Sigma PS fixed model.Materials and methodsIn this randomized controlled trial, we analyzed 50 knees that underwent TKA with PFC Sigma
A. Chaudhry, V. Goyal
semanticscholar +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
PENERAPAN ACTIVITY BASED COSTING SYSTEM SEBAGAI ALTERNATIF SISTEM PENENTUAN BIAYA RAWAT INAP PADA RUMAH SAKIT (Studi Kasus Pada Rumah Sakit Islam Yaksi Gemolong, Sragen) [PDF]
, 2010 Penelitian ini mengambil judul “Penerapan Activity Based Costing System Sebagai Alternatif Sistem Penentuan Biaya Rawat Inap Pada Rumah Sakit Yaksi.” Tujuan yang ingin dicapai dari penelitian yang dilakukan adalah untuk mengetahui perhitungan biaya ...
HIDAYATI , ANNISA
core
Journal of Clinical Oncology, 2019 PURPOSE Patients with locally advanced prostate cancer have an increased risk of cancer recurrence and mortality. In this phase II trial, we evaluate neoadjuvant enzalutamide and leuprolide (EL) with or without abiraterone and prednisone (ELAP) before ...
R. McKay +18 more
semanticscholar +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source