Results 191 to 200 of about 161,381 (305)

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

Ulnar lengthening for forearm deformities in hereditary multiple exostoses: a systematic review and meta-analysis (2015-2025). [PDF]

J Orthop Surg Res
Hamza MS.
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Postoperative Chemotherapy in Stage IIA Gastric Cancer: Not Always Necessary

Medicine Advances, EarlyView.
Postoperative chemotherapy (POCT) in stage IIA gastric cancer was associated with improved overall survival but did not significantly improve disease‐specific survival after propensity score matching. The benefit of POCT varied across subgroups, with limited benefit in patients with favorable tumor biology and potential benefit in higher‐risk patients.
Yuan Zheng, Di Zhang, Hossein Mehrabanidil, Jiaoyang Lu   +3 more
wiley   +1 more source

Recognizing Gastric Oxyntic Gland Neoplasms: Characteristic Endoscopic Appearance for Improved Detection. [PDF]

Endosc Int Open
Chen L, Sun XG, Liu FG, Zhang XY, Zhao J, Shan TD.   +5 more
europepmc   +1 more source

Non‐Cyclic Rozanolixizumab Administration in Complex Generalized Myasthenia Gravis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Rozanolixizumab, an inhibitor of the neonatal Fc receptor (FcRn), is used to treat patients with generalized myasthenia gravis (gMG) refractory to standard therapies. However, the approved six‐week cyclic regimen may be associated with a “wearing‐off” effect and disease fluctuations. We evaluated the non‐cyclic administration
Marc Abi Aoun, Diane Beauvais, Marlène Barnay, Marie‐Hélène Violleau, Stéphane Mathis, Fanny Duval, Guilhem Sole   +6 more
wiley   +1 more source

Myosin IIA motor regulates attaching-effacing bacteria interactions with intestinal epithelium. [PDF]

Gut Microbes
Naydenov NG, Zafar A, Lechuga S, Zalavadia A, Marino-Melendez A, Hammer JA, Fowler VM, McDonald C, Campellone KG, Ivanov AI.   +9 more
europepmc   +1 more source

Negative symbolism of wildlife shapes human–nature coexistence: The plight of owls in Nigeria

People and Nature, EarlyView.
Abstract Human–wildlife coexistence in culturally diverse landscapes requires understanding how socio‐cultural processes shape perceptions and behaviours towards conservation‐priority species. This study examines perceptions, belief‐based uses and conservation attitudes towards owls in communities surrounding six Protected Areas in Nigeria, addressing ...
Iniunam Aniefiok Iniunam, Joan Fadzai Banda, Talatu Tende, Danjuma Filibus Dami, Ulf Ottosson, Adams Adamanyiwa Chaskda   +5 more
wiley   +1 more source

1-year results after surgery for flexible adult-acquired flatfoot deformity: a cohort study based on 190 patients from the Swedish Foot and Ankle Surgery Register. [PDF]

Acta Orthop
Osbeck IKJ, Cöster M, Atroshi I.
europepmc   +1 more source