Results 241 to 250 of about 2,610,317 (379)

IL-1β alters the virulence of uropathogenic Escherichia coli. [PDF]

Sci Rep
Kalaycı-Yüksek F, Wu R, Rangel I, Demirel I.   +3 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Association of IL-1β rs16944 polymorphisms and the subsequent level of IL-1β in type 2 diabetes mellitus: Case-control study. [PDF]

Medicine (Baltimore)
Khdaer HM, Aldabagh MAH, Abdulrazzaq ZT, Altai GA, Issa AA, Jabir MS, Najm MAA, Hasan TF, Jawad SF, Fawzi HA, Jasim ST, Swelum AA.   +11 more
europepmc   +1 more source

IL-1β blockade prevents cardiotoxicity and improves the efficacy of immune checkpoint blockers and chemotherapy against pancreatic cancer in mice with obesity

Nilesh P. Talele, Heena Kumra, Igor L. Gomes‐Santos, William W. Ho, Patrik L. Andersson, Marie Siwicki, Peigen Huang, Dan G. Duda, Mikäel J. Pittet, Dai Fukumura, Rakesh K. Jain   +10 more
openalex   +1 more source

Molecular mechanisms involved in interleukin 1-beta (IL-1β)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (α-MSH)

, 2013
Patricia González, I. Machado, A. Alejandro Vilcaes, Carla Caruso, German A. Roth, Helgi B. Schiöth, Mercedes Lasaga, Teresa Scimonelli   +7 more
openalex   +2 more sources

IL-1β-Mediated Innate Immunity Is Amplified in the db/db Mouse Model of Type 2 Diabetes [PDF]

, 2005
Jason C. O’Connor, Ansuman T. Satpathy, Matthew E. Hartman, E Horváth, Keith W. Kelley, Robert Dantzer, Rodney W. Johnson, Gregory G. Freund   +7 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Design and Synthesis of Novel Purine Analogues as Potential IL-1β Inhibitors Targeting Vascular Inflammation. [PDF]

Chem Biodivers
Pournara DT, Fotopoulou T, Paramel G, Lindkvist M, Grenegård M, Fransén K, Koufaki M.   +6 more
europepmc   +1 more source

The association of IL-1β, IL-1α, IL-6, and E-selectin with the diastolic dysfunction in patients with type 2 diabetes mellitus and preserved ejection fraction

Dejan Marinkovic, Tamara Dragovic, Predrag Djurić, Jelena Rakočević, Dragana Malovic, Sasa Kikovic, Ivan Stanojević, Bratislav Dejanović, Petar Ristić, Zoran Hajdukovic   +9 more
openalex   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source