Results 261 to 270 of about 2,610,317 (379)

IL-1β and HMGB1 in Epileptogenesis: Recent Advances and Clinical Translation. [PDF]

Pharmaceuticals (Basel)
Geng H, Sha L, Chen L.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Exploring the predictive potentials of IL-1β and TNFR1 in atherogenic risk in prediabetes. [PDF]

Sci Rep
Ayash R, Kabalan Y, Chamaa S.
europepmc   +1 more source

New Insights into the Role of IL-1β in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis [PDF]

, 2017
Chih‐Chung Lin, Brian T. Edelson
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis. [PDF]

Chin Med
Jiang Y, Zhang S, Guan H, Lv K, Yu J, Li S, Jia R, Zhang X, Ma S, Qu J, Lin J.   +10 more
europepmc   +1 more source

Author response: Opposing Regulation of TNF Responses by IFN-γ and a PGE2-cAMP Axis that is Apparent in Rheumatoid and Immune Checkpoint Inhibitor-induced Arthritis IL-1β+ Macrophages

Upneet K. Sokhi, Ruoxi Yuan, Bikash Mishra, Yuri Chinenov, Anvita Singaraju, Karmela K Chan, Anne R. Bass, Richard D. Bell, Laura T. Donlin, Lionel B. Ivashkiv   +9 more
openalex   +1 more source

IL‐1β Induces p62/SQSTM1 and Represses Androgen Receptor Expression in Prostate Cancer Cells

, 2014
Megan Chang, Viral Patel, Michael Gwede, Micaela Morgado, Kelly M. Tomasevich, Eliza Li Shan Fong, Mary C. Farach‐Carson, Nikkí A. Delk   +7 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Antroquinonol reduces IL-1β production in macrophages through enhancing the DNA methylation of <i>Tlr4</i>. [PDF]

Front Nutr
Bin P, Fu Z, Wang Z, Hung I, Liu C, Peng W, Wang K, Mo J.   +7 more
europepmc   +1 more source