Results 301 to 310 of about 15,170,590 (380)

Revolutionizing nephrocalcinosis treatment: IL-10 engineered macrophages as a novel therapeutic approach. [PDF]

Bioeng Transl Med
Zhao W, Wang K, Chen H, Xu J, Wen L, Wu Y, Chen W, Liu H, Liu Y, Zhang J, Lieske JC, Zhang L, Zhang X, Mai H.   +13 more
europepmc   +1 more source

Suppression of antigen presentation by IL-10.

Current Opinion in Immunology, 2015
S. Mittal, P. Roche
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Sex Bias in IL-10 Production by Type I Regulatory T Cells Regulated by PI3K/mTOR Signaling. [PDF]

Neurol Neuroimmunol Neuroinflamm
Debonlier A, Kari S, Bucciarelli F, Angles T, Perez-Pestel A, Fébrissy C, Laffont S, Liblau R, Lenfant F, Dunn SE, Guillermet-Guibert J, Astier AL.   +11 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Induction of endogenous IL-10 promotes resolution and tolerance of nitric oxide in microglia. [PDF]

Brain Behav Immun Health
Kuo HC, Chen JS, Chao CN, Lee KF, Huang YT, Mao PC, Lin TC, Chiu SC, Huang YL, Chu CH.   +9 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Co-delivery of endometrial mesenchymal stem cells and macrophages with an electrospun patch suppresses endometrial fibrosis via IL-10 related signaling. [PDF]

Front Immunol
An J, Li S, Ma T, Chen Y, Santerre JP, Wang W, Ma P, Zhang X.   +7 more
europepmc   +1 more source

Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model

, 2016
Silvina del Carmen, Alejandra de Moreno de LeBlanc, Romina Levit, Vasco Azevedo, Philippe Langella, Luis G. Bermúdez‐Humarán, Jean Guy LeBlanc   +6 more
openalex   +2 more sources