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IL-10 or not IL-10: that is the question
Nature Immunology, 2007Four new papers focused on how interleukin 10–producing cells are induced have led to some unexpected and intriguing observations on the nature of interleukin 17–producing T helper cells.
Dragana Jankovic, Giorgio Trinchieri
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1995
In the 5 years since its discovery, the pleiotropic cytokine IL-10 has been shown to play an important role in the regulation of lymphoid and myeloid cells. IL-10 was detected independently in several laboratories. Fiorentino et al. [1] described a cytokine secreted by ‘type 2’ murine helper T-cell clones which inhibited cytokine production by ‘type 1’
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In the 5 years since its discovery, the pleiotropic cytokine IL-10 has been shown to play an important role in the regulation of lymphoid and myeloid cells. IL-10 was detected independently in several laboratories. Fiorentino et al. [1] described a cytokine secreted by ‘type 2’ murine helper T-cell clones which inhibited cytokine production by ‘type 1’
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IL-10 immunosuppression in transplantation
Current Opinion in Immunology, 1995The description of IL-10 as an immunosuppressive cytokine that inhibits numerous T-cell and antigen-presenting cell functions has led to the investigation of the role of IL-10 in graft acceptance and rejection, in both manipulated and unmanipulated experimental systems.
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Cytokine & Growth Factor Reviews, 2010
In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped into the so-called IL-10 family of cytokines based on their similarities with respect to the structure and location of their encoding genes, their primary and secondary protein structures, and the receptor complexes used.
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In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped into the so-called IL-10 family of cytokines based on their similarities with respect to the structure and location of their encoding genes, their primary and secondary protein structures, and the receptor complexes used.
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Functional Characterization of Human IL-10
International Archives of Allergy and Immunology, 1992Rapid progress has been made over the past two years in the characterization of the biological activities of interleukin-10. Interleukin-10, produced by T cells, B cells, macrophages/monocytes and keratinocytes, alters profoundly the morphology, the expression of MHC class II antigens and the production of cytokines by monocytes which in turn can ...
H, Spits, R, de Waal Malefyt
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Trends in Immunology, 2003
Classification of cytokines as pro-versus anti-inflammatory might not apply to the pleiotropic effects of interleukin-10 (IL-10). Several reports suggest that IL-10 enhances the function of natural killer cells, which leads, through pathogen destruction, to increased antigen availability.
MOCELLIN, SIMONE +4 more
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Classification of cytokines as pro-versus anti-inflammatory might not apply to the pleiotropic effects of interleukin-10 (IL-10). Several reports suggest that IL-10 enhances the function of natural killer cells, which leads, through pathogen destruction, to increased antigen availability.
MOCELLIN, SIMONE +4 more
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2007
Soon after the principles of nonself immunological recognition were discovered, it was realized that the state of pregnancy seemingly presents a paradox. In an outbreed population, half of the fetal genes are paternal, thus the fetus may be considered a semi-allograft.
Shaun P. Murphy, Surendra Sharma
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Soon after the principles of nonself immunological recognition were discovered, it was realized that the state of pregnancy seemingly presents a paradox. In an outbreed population, half of the fetal genes are paternal, thus the fetus may be considered a semi-allograft.
Shaun P. Murphy, Surendra Sharma
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Staphylococcus aureus metabolites promote IL-10
Nature Microbiology, 2020Glycolytic Staphylococcus aureus generate lactate that targets specific histone deacetylases to stimulate the production of IL-10 and enable biofilm formation.
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1995
Anumber of in vitro studies demonstrated strong immunoinhibition by IL-10, and suggest a role for it as a potential agent for the treatment of autoimmune diseases such as type I diabetes and multiple sclerosis, or for the prolongation of allograft survival.
Myung-Shik Lee, Nora Sarvetnick
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Anumber of in vitro studies demonstrated strong immunoinhibition by IL-10, and suggest a role for it as a potential agent for the treatment of autoimmune diseases such as type I diabetes and multiple sclerosis, or for the prolongation of allograft survival.
Myung-Shik Lee, Nora Sarvetnick
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The regulation of IL-10 production by immune cells
Nature reviews. Immunology, 2010M. Saraiva, A. O’Garra
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