Results 331 to 340 of about 15,170,590 (380)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Correlation and combined predictive value analysis of serum IL-6 and IL-10 levels with tumor progression in patients with cervical cancer. [PDF]

Eur J Med Res
Cheng L, Guo C, Yang Y.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage. [PDF]

J Neuroinflammation
Reyes-Esteves S, Majumder A, Marzolini N, Zamora ME, Jeong S, Wang Y, Patel MN, Espy C, Papp TE, Akyianu A, Nong J, Messe L, Omo-Lamai S, Parhiz H, Myerson JW, Marcos-Contreras OA, Brenner JS.   +16 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

PD-1 blockade promotes mucosal CD4+ T cell IL-10 production through altering microbiota to reduce intestinal ischemia reperfusion injury. [PDF]

Gut Microbes
Wen SH, Zhang YN, Shen JT, Guo Y, Chang ZN, Zhang HF, Liu ZM, Zhang XY.   +7 more
europepmc   +1 more source

Metabolic regulation of T cell production of IL-10 and IL-22 protects against intestinal inflammation. [PDF]

Precis Clin Med
Liu H, Zhao X, Yu T, Yu Y, Yao S, Yang W, Cong Y.   +6 more
europepmc   +1 more source

FMDV VP3 Induces IL-10 Expression in Porcine Macrophages via PI3K Interaction and PI3K/AKT-mTOR Pathway Activation. [PDF]

Viruses
Li Y, Guo Z, Zhang Y, Luo L, He C, Xia Q, Zhang J, Zhang Z, Li Y.   +8 more
europepmc   +1 more source

Anthocyanin Supplementation and Inflammation: A Systematic Review and Meta-Analysis of IL-8, IL-10, IL-18, IFN-γ, and Resistin in Healthy, Overweight, and Obese Populations. [PDF]

Food Sci Nutr
Young A, Ajaz M, Vugic L, Shilton N.
europepmc   +1 more source

Coupling IL-2 with IL-10 to mitigate toxicity and enhance antitumor immunity. [PDF]

Cell Rep Med
Ahn JJ, Dudics S, Langan DP, Smith JD, Hsu AH, McCright JC, Smith SR, Castleberry AL, George BI, Goitía Vázquez JA, Kuri PN, Alla SSV, Garcia J, Haider YM, Hamdan FW, Juárez JE, Reddy R, Shanmuganathan A, Wang Y, Welch A, Boclair D, Khrimian PA, Yaen CH, Mumm JB.   +23 more
europepmc   +1 more source