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Journal of Allergy and Clinical Immunology, 2004
A new family of cytokines, IL-17, has recently been defined that reveals a distinct ligand-receptor signaling system. Functional studies have provided evidence for its importance in the regulation of immune responses. Notably, 3 members, IL-17A, IL-17E (IL-25), and IL-17F, have been best characterized both in vitro and in vivo , and have been shown to ...
Mio, Kawaguchi +4 more
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A new family of cytokines, IL-17, has recently been defined that reveals a distinct ligand-receptor signaling system. Functional studies have provided evidence for its importance in the regulation of immune responses. Notably, 3 members, IL-17A, IL-17E (IL-25), and IL-17F, have been best characterized both in vitro and in vivo , and have been shown to ...
Mio, Kawaguchi +4 more
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Expert Review of Respiratory Medicine, 2012
Asthma is perceived as a heterogeneous disease with several clinical phenotypes and triggering factors. In general, cytokines from T-helper 2 cells are believed to be critical contributors of asthma. In recent years, IL-17, another T-helper lymphocyte-associated cytokine, has been put forward as another potentially important mediator of asthma ...
Elin, Silverpil, Anders, Lindén
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Asthma is perceived as a heterogeneous disease with several clinical phenotypes and triggering factors. In general, cytokines from T-helper 2 cells are believed to be critical contributors of asthma. In recent years, IL-17, another T-helper lymphocyte-associated cytokine, has been put forward as another potentially important mediator of asthma ...
Elin, Silverpil, Anders, Lindén
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Annual Review of Immunology, 2009
CD4+T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions. Until recently, T cells were divided into Th1 or Th2 cells, depending on the cytokines they produce.
Thomas, Korn +3 more
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CD4+T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions. Until recently, T cells were divided into Th1 or Th2 cells, depending on the cytokines they produce.
Thomas, Korn +3 more
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Expert Review of Clinical Immunology, 2019
Introduction: Psoriasis is a chronic, immune-mediated disease with significant associated comorbidities. Its pathogenesis is likely multifactorial, however, the interleukin-23/T helper 17 pathway has been identified as a critical axis in its pathogenesis.
Karen Ly +5 more
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Introduction: Psoriasis is a chronic, immune-mediated disease with significant associated comorbidities. Its pathogenesis is likely multifactorial, however, the interleukin-23/T helper 17 pathway has been identified as a critical axis in its pathogenesis.
Karen Ly +5 more
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IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential
Clinical Science, 2012IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in host defence against bacterial and fungal infections, as well as in the pathogenesis of autoimmune diseases. The present review focuses on current knowledge of the regulation, functional mechanisms and targeting strategies of IL-17 in the context of ...
Shu, Zhu, Youcun, Qian
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Nature Reviews Immunology, 2019
IL-17-producing γδ T cells in the meningeal spaces support short-term spatial memory formation.
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IL-17-producing γδ T cells in the meningeal spaces support short-term spatial memory formation.
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Blood, 2011
In this issue of Blood , the functional attributes of human Vγ9Vδ2 T cells are firmly extended to the secretion of the proinflammatory cytokine IL-17.[1][1] Over the past 5 years, immunology has been marked by intense investigation of the production of IL-17 by various populations of T cells ...
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In this issue of Blood , the functional attributes of human Vγ9Vδ2 T cells are firmly extended to the secretion of the proinflammatory cytokine IL-17.[1][1] Over the past 5 years, immunology has been marked by intense investigation of the production of IL-17 by various populations of T cells ...
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2006
IL-17A and its receptor are the founding members of a recently described cytokine family, with unique sequences and functions in the immune system and elsewhere. Consisting of six ligands (IL-17A-F) and five receptors (IL-17RA-IL-17RE) in mammals, these molecules have distinct primary amino acid structures with only minimal homology to other cytokine ...
Sarah L, Gaffen +3 more
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IL-17A and its receptor are the founding members of a recently described cytokine family, with unique sequences and functions in the immune system and elsewhere. Consisting of six ligands (IL-17A-F) and five receptors (IL-17RA-IL-17RE) in mammals, these molecules have distinct primary amino acid structures with only minimal homology to other cytokine ...
Sarah L, Gaffen +3 more
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Nature Reviews Immunology, 2019
During inflammation, IL-17 rewires metabolic processes in lymph node fibroblastic reticular cells, thereby supporting their survival and population expansion.
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During inflammation, IL-17 rewires metabolic processes in lymph node fibroblastic reticular cells, thereby supporting their survival and population expansion.
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