IL-1R8 as Pathoimmunological Marker for Severity of Canine Chronic Enteropathy [PDF]
Veterinary Sciences, 2022 Chronic enteropathy (CE) is a severe multifactorial gastrointestinal disease that affects dogs and is driven by poorly characterized inflammatory pathways.
Federica Riva +5 more
doaj +4 more sources
IL-1R8 Downregulation and Concomitant TLR7 and TLR9 Upregulation Are Related to the Pathogenesis of Canine Diffuse Large B-Cell Lymphoma [PDF]
Veterinary Sciences, 2022 Diffuse large B-cell lymphoma (DLBCL) is the most common hematological malignancy in humans and dogs. Several studies disclosed some similarities between the two species, including the constitutive activation of the NF-κB pathway as a fundamental ...
Federica Riva +10 more
doaj +7 more sources
IL-1R8 silencing improves the anti-tumor function of freshly isolated human NK cells [PDF]
Journal for ImmunoTherapy of Cancer, 2022 The inhibitory receptor interleukin-1 receptor 8 (IL-1R8) has been recently recognized to be expressed also by human natural killer (NK) cells. This study was aimed to design and optimize IL-1R8 silencing conditions in human NK cells to precisely ...
Enrico Maggi +11 more
doaj +4 more sources
IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8. [PDF]
Theranostics, 2021 Background: Interleukin 37 (IL-37), a member of IL-1 family, broadly suppresses inflammation in many pathological conditions by acting as a dual-function cytokine in that IL-37 signals via the extracellular receptor complex IL1-R5/IL-1R8, but it can also
Sánchez-Fernández A +8 more
europepmc +10 more sources
The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammationResearch in context [PDF]
EBioMedicine, 2019 Background: The Single immunoglobin interleukin-1 (IL-1)-related receptor (Sigirr), also known as IL-1R8, has been shown to exhibit broad anti-inflammatory effects against inflammatory diseases including acute lung injury, while molecular regulation of ...
Lian Li +7 more
doaj +6 more sources
IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway [PDF]
Cell Death and Disease, 2021 Kawasaki disease (KD) is an acute vasculitis of pediatric populations that may develop coronary artery aneurysms if untreated. It has been regarded as the principal cause of acquired heart disease in children of the developed countries.
Chang Jia +10 more
doaj +5 more sources
Regulatory role of IL-1R8 in immunity and disease [PDF]
Frontiers in Immunology, 2016 Interleukin-1 receptor family members (ILRs) and Toll Like Receptors (TLRs) are characterized by the presence of a conserved intracellular domain, the Toll/IL-1resistance (TIR) domain and are key players in immunity and inflammation.
Martina eMolgora +4 more
doaj +4 more sources
Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease [PDF]
Frontiers in Immunology, 2022 Interleukin-1 (IL-1) is a primary cytokine of innate immunity and inflammation. IL-1 belongs to a complex family including ligands with agonist activity, receptor antagonists, and an anti-inflammatory cytokine.
Domenico Supino +8 more
doaj +6 more sources
Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects [PDF]
eLife, 2017 Inflammation modifies risk and/or severity of a variety of brain diseases through still elusive molecular mechanisms. Here we show that hyperactivation of the interleukin 1 pathway, through either ablation of the interleukin 1 receptor 8 (IL-1R8, also ...
Romana Tomasoni +12 more
doaj +6 more sources
IL-37/IL-1R8 axis: a novel major mechanism of control at the interface between tumor and immune cells [PDF]
OncoImmunologyInterleukin (IL)-37 is one of the “youngest” IL-1 family members and one of the few molecules exerting anti-inflammatory activity. Upon inflammasome activation, the cytokine precursor is converted into its mature form, which acts intracellularly as a ...
Nadine Landolina +7 more
doaj +2 more sources