Potential Role of IL-37 in Atopic Dermatitis [PDF]
Cells, 2023 Interleukin 37 (IL-37) is a recently discovered member of the IL-1 cytokine family that appears to have anti-inflammatory and immunosuppressive effects in various diseases.
Alicja Mesjasz +3 more
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The role of IL-37 in gastrointestinal diseases [PDF]
Frontiers in ImmunologyGastrointestinal mucosal surface is frequently under challenge due to it’s the large surface area and most common entry of microbes. IL-37, an anti-inflammatory cytokine, regulates local and systemic host immunity. H.
Qiang Wang +5 more
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The Role of IL-37 and IL-38 in Colorectal Cancer [PDF]
Frontiers in Medicine, 2022 Colorectal cancer (CRC) is a major killer. Dysregulation of IL-37 and IL-38, both anti-inflammatory cytokines, is observed in auto-immune diseases.
Jie Dang +8 more
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IL-37/IL-1R8 axis: a novel major mechanism of control at the interface between tumor and immune cells [PDF]
OncoImmunologyInterleukin (IL)-37 is one of the “youngest” IL-1 family members and one of the few molecules exerting anti-inflammatory activity. Upon inflammasome activation, the cytokine precursor is converted into its mature form, which acts intracellularly as a ...
Nadine Landolina +7 more
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The Role of IL-37 and IL-38 in Obstetrics Abnormalities [PDF]
Frontiers in Medicine, 2021 There are two fairly common complications during pregnancy, i.e., gestational diabetes mellitus (GDM) and pre-eclampsia, which are independent, but are also closely linked in prevalence in pregnant women, with potential serious adverse consequences.
Mei Wang
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IL-35, IL-37, and IL-38 in acute pancreatitis: proposed immunopathogenic mechanisms and therapeutic potential [PDF]
Frontiers in ImmunologyAcute pancreatitis (AP) is driven by premature enzyme activation, pancreatic tissue injury, and dysregulated immune responses. IL-35 and IL-37 are key anti-inflammatory mediators whose dynamic regulation influences disease severity.
Hailong Yan +6 more
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The role of IL-37 and IL-38 in rheumatoid arthritis, the potential clinical applications in precision medicine [PDF]
Frontiers in ImmunologyRheumatoid arthritis (RA) is a chronic, autoimmune inflammatory disorder that primarily affects the joints, and in severe cases, can damage other major organs, particularly in susceptible individuals.
Haifeng Zhang +6 more
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The distinct roles of IL-37 and IL-38 in non-small cell lung carcinoma and their clinical implications [PDF]
Frontiers in ImmunologyLung cancer, a significant global health challenge, is primarily classified into non-small cell lung cancer (NSCLC) and small cell lung cancer. Despite advancements in targeted therapies and immunotherapies, NSCLC outcomes remain poor, with low five-year
Jiwei Zhang +4 more
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IL-37-a putative therapeutic agent in cardiovascular diseases. [PDF]
QJM, 2022 Summary Although it is a member of the Interleukin (IL)-1 family, IL-37 is unique in that it has wide-ranging anti-inflammatory characteristics. It was originally thought to prevent IL-18-mediated inflammation by binding to the IL-18-binding protein.
McCurdy S +4 more
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High-dose IL-37 promotes inflammatory activity of macrophage via Preferential ligation of the IL-18Rα [PDF]
Scientific ReportsInterleukin-37 (IL-37) exists in various human tissues and organs and exhibits extensive anti-inflammatory activity. Recombinant IL-37 ameliorates the insulin resistance and inflammation associated with obesity and type 2 diabetes (T2DM).
Yu Zhang +9 more
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