IL-37 and IL-38 in sepsis: immune-metabolic rheostats in a dynamic inflammatory continuum [PDF]
Frontiers in ImmunologySepsis is a life-threatening syndrome driven by a dysregulated host response to infection, characterised by dynamic and overlapping phases of hyperinflammation and immune suppression.
Hailong Yan +9 more
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The Role of IL-37 and IL-38 in Colorectal Cancer [PDF]
Frontiers in Medicine, 2022 Colorectal cancer (CRC) is a major killer. Dysregulation of IL-37 and IL-38, both anti-inflammatory cytokines, is observed in auto-immune diseases.
Jie Dang +8 more
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Serum IL-38 Level Was Associated with Incidence of MACE in the STEMI Patients [PDF]
International Journal of General Medicine, 2023 Chengbo Lu,1,* Fanghui Zhou,2,* Huimin Xian,3,* Siyuan Sun,4 Jingkun Yue,4 Ying Zhang,5 Qi Zhao,6 Xing Luo,3 Yang Li7 1Department of Cardiology, 1st Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, People’s Republic of China;
Lu C +8 more
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Dichotomous roles of IL-36 and IL-38 in cardiovascular disease [PDF]
Frontiers in ImmunologyMembers of the interleukin-1 (IL-1) superfamily play crucial roles in orchestrating inflammation and immune responses. Among them, IL-36 and IL-38 have emerged as cytokines with contrasting roles in cardiovascular disease (CVD).
Haifeng Zhang, Wenhui Huang, Shisan Bao
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IL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation [PDF]
mAbs, 2023 Immune checkpoint inhibitors that overcome T cell suppressive mechanisms in tumors have revolutionized the treatment of cancer but are only efficacious in a small subset of patients.
John P. Dowling +14 more
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IL-38 Gene Deletion Worsens Murine Colitis [PDF]
Frontiers in Immunology, 2022 IL-38 is a recently discovered cytokine and member of the IL-1 Family. In the IL-1 Family, IL-38 is unique because the cytokine is primarily a B lymphocyte product and functions to suppress inflammation. Studies in humans with inflammatory bowel disease (
Dennis M. de Graaf +13 more
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The distinct roles of IL-37 and IL-38 in non-small cell lung carcinoma and their clinical implications [PDF]
Frontiers in ImmunologyLung cancer, a significant global health challenge, is primarily classified into non-small cell lung cancer (NSCLC) and small cell lung cancer. Despite advancements in targeted therapies and immunotherapies, NSCLC outcomes remain poor, with low five-year
Jiwei Zhang +4 more
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The role of IL-37 and IL-38 in rheumatoid arthritis, the potential clinical applications in precision medicine [PDF]
Frontiers in ImmunologyRheumatoid arthritis (RA) is a chronic, autoimmune inflammatory disorder that primarily affects the joints, and in severe cases, can damage other major organs, particularly in susceptible individuals.
Haifeng Zhang +6 more
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The differential role of IL-33 and IL-38 in prostate cancer, contradictory roles [PDF]
Frontiers in ImmunologyProstate cancer (PCa) is still as a major cause of morbidity and mortality in men at the global level, highlighting the necessity for improved diagnostic and therapeutic strategies beyond current PSA screening limitations. This mini-review focuses on the
Runfen Ban +3 more
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The Role of IL-37 and IL-38 in Obstetrics Abnormalities [PDF]
Frontiers in Medicine, 2021 There are two fairly common complications during pregnancy, i.e., gestational diabetes mellitus (GDM) and pre-eclampsia, which are independent, but are also closely linked in prevalence in pregnant women, with potential serious adverse consequences.
Mei Wang
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