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Circulating interleukin-38 concentrations in healthy adults [PDF]
Frontiers in Immunology, 2022 Interleukin (IL)-38 is the latest discovered member of the interleukin-1 family, which has anti-inflammatory properties similar to IL-36Ra. Several studies compared circulating IL-38 concentrations in healthy and diseased populations to characterize its role in both auto-immune and inflammatory pathologies, with both higher and lower concentrations ...
Lisa U. Teufel +10 more
doaj +8 more sources
Interleukin-38 and cardiovascular pathology: literature review [PDF]
CardioSomatics, 2023 Cardiovascular pathology is a leading cause of morbidity and mortality. An important task of modern cardiology is the search and study of new biological markers. Scientists’ interest is actively focused on the study of interleukin-38. Interleukin-38 is an anti-inflammatory cytokine and a member of the interleukin-1 family.
Amina M. Alieva +4 more
doaj +3 more sources
Exploratory analysis of interleukin‐38 in hospitalized COVID‐19 patients [PDF]
Immunity, Inflammation and Disease, 2022 Abstract Introduction A major contributor to coronavirus disease 2019 (COVID‐19) progression and severity is a dysregulated innate and adaptive immune response. Interleukin‐38 (IL−38) is an IL‐1 family member with broad anti‐inflammatory properties, but thus far little is known about its role ...
Dennis M. deGraaf +12 more
doaj +6 more sources
The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy [PDF]
Scientific Reports, 2017 AbstractInterleukin 38 (IL-38) is a novel identified cytokine of IL-1 family in which some members are important in inflammation and angiogenesis. However, the role of IL-38 in regulating angiogenesis is unknown. The aim of the present study is to explore the effect of IL-38 on angiogenesis.
Jing Zhang +9 more
doaj +4 more sources
Opposing Effects of Interleukin-36γ and Interleukin-38 on Trained Immunity [PDF]
International Journal of Molecular Sciences, 2023 Trained immunity is the process of long-term functional reprogramming (a de facto innate immune memory) of innate immune cells such as monocytes and macrophages after an exposure to pathogens, vaccines, or their ligands. The induction of trained immunity is mediated through epigenetic and metabolic mechanisms.
Lisa U. Teufel +5 more
openaire +4 more sources
Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3 [PDF]
Proceedings of the National Academy of Sciences, 2022 Calcific aortic valve disease (CAVD) is common in people over the age of 65. Progressive valvular calcification is a characteristic of CAVD and due to chronic inflammation in aortic valve interstitial cells (AVICs) resulting in CAVD progression. IL-38 is a naturally occurring anti-inflammatory cytokine; here, we report lower levels of endogenous IL-38 ...
Erlinda The +7 more
openaire +3 more sources
Interleukin‐38 alleviates cardiac remodelling after myocardial infarction [PDF]
Journal of Cellular and Molecular Medicine, 2019 AbstractExcessive immune‐mediated inflammatory reaction plays a deleterious role in ventricular remodelling after myocardial infarction (MI). Interleukin (IL)‐38 is a newly characterized cytokine of the IL‐1 family and has been reported to exert a protective effect in some autoimmune diseases.
Yuzhen Wei +9 more
openaire +3 more sources
Interleukin-38 in Health and Disease [PDF]
Cytokine, 2022 Contains fulltext : 252005.pdf (Publisher’s version ) (Open Access)
Graaf, D.M. de +3 more
openaire +3 more sources
Interleukin‐38: A crucial player in periodontitis
Oral Diseases, 2023 Abstract Background The objective of this study was to compare the levels of gingival crevicular fluid (GCF), salivary, and serum matrix metalloproteinase‐9, interleukin (IL)‐17, IL‐36γ, and IL‐38 in individuals with healthy periodontium, gingivitis, and periodontitis and to evaluate their ...
Hilal Korkmaz +2 more
openaire +2 more sources
Interleukin 38 Protects Against Lethal Sepsis [PDF]
The Journal of Infectious Diseases, 2018 Interleukin 38 (IL-38) is the most recently characterized cytokine of the interleukin 1 family. However, its role in sepsis remains unknown.Circulating IL-38 levels were measured in 2 cohorts of adult and pediatric patients with sepsis. Using 2 murine models of lipopolysaccharide (LPS)-induced endotoxemia and cecal ligation and puncture (CLP)-induced ...
Fang, Xu +6 more
openaire +2 more sources