Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review [PDF]
Frontiers in Immunology, 2018 Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta,
Wang-Dong Xu, An-Fang Huang
doaj +8 more sources
Circulating interleukin-38 concentrations in healthy adults [PDF]
Frontiers in Immunology, 2022 Interleukin (IL)-38 is the latest discovered member of the interleukin-1 family, which has anti-inflammatory properties similar to IL-36Ra. Several studies compared circulating IL-38 concentrations in healthy and diseased populations to characterize its ...
Lisa U. Teufel +10 more
doaj +7 more sources
Neutralization of interleukin-38 exacerbates coxsackievirus B3-induced acute myocarditis in mice [PDF]
Virology Journal, 2021 Background Interleukin (IL)-38, a novel member of the IL-1 family, has been reported to be involved in several diseases associated with viral infection. However, the expression and functional role of IL-38 in acute viral myocarditis (AVMC) have not been ...
Yimin Xue +7 more
doaj +6 more sources
Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes. [PDF]
PLoS ONE, 2019 Interleukin (IL)-38 is a member of the IL-1 family of cytokines, which was proposed to exert anti-inflammatory effects. IL-38 is constitutively expressed in the skin, where keratinocytes are the main producing cells.
Dominique Talabot-Ayer +8 more
doaj +8 more sources
Interleukin-38 and cardiovascular pathology: literature review [PDF]
КардиоСоматика, 2023 Cardiovascular pathology is a leading cause of morbidity and mortality. An important task of modern cardiology is the search and study of new biological markers. Scientists’ interest is actively focused on the study of interleukin-38.
Amina M. Alieva +4 more
doaj +3 more sources
Opposing Effects of Interleukin-36γ and Interleukin-38 on Trained Immunity. [PDF]
Int J Mol Sci, 2023 Trained immunity is the process of long-term functional reprogramming (a de facto innate immune memory) of innate immune cells such as monocytes and macrophages after an exposure to pathogens, vaccines, or their ligands. The induction of trained immunity
Teufel LU +5 more
europepmc +5 more sources
Exploratory analysis of interleukin‐38 in hospitalized COVID‐19 patients [PDF]
Immunity, Inflammation and Disease, 2022 Introduction A major contributor to coronavirus disease 2019 (COVID‐19) progression and severity is a dysregulated innate and adaptive immune response. Interleukin‐38 (IL−38) is an IL‐1 family member with broad anti‐inflammatory properties, but thus far ...
Dennis M. deGraaf +12 more
doaj +6 more sources
Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Calcific aortic valve disease (CAVD) is a common aging-related cardiovascular disease with no pharmacological therapy presently. CAVD pathobiology has chronic inflammation and progressive calcification in aortic valve leaflets. We found that
The E +7 more
europepmc +4 more sources
Interleukin‐38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2‐p38 pathway‐dependent manner [PDF]
Physiological Reports, 2023 Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin‐38 (IL‐38) is a member of the IL‐
Shun Kurose +7 more
doaj +3 more sources
Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner. [PDF]
EMBO Rep, 2022 Interleukin‐38 (IL‐38) is strongly associated with chronic inflammatory diseases; however, its role in tumorigenesis is poorly understood. We demonstrated that expression of IL‐38, which exhibits high expression in the skin, is downregulated in human ...
Zhou H +24 more
europepmc +4 more sources