Results 1 to 10 of about 413,257 (99)

Circulating interleukin-38 concentrations in healthy adults. [PDF]

Front Immunol, 2022
Interleukin (IL)-38 is the latest discovered member of the interleukin-1 family, which has anti-inflammatory properties similar to IL-36Ra. Several studies compared circulating IL-38 concentrations in healthy and diseased populations to characterize its ...
Teufel LU, de Graaf DM, Netea MG, Dinarello CA, Joosten LAB, Arts RJW.   +5 more
europepmc   +2 more sources

Exploratory analysis of interleukin-38 in hospitalized COVID-19 patients. [PDF]

Immun Inflamm Dis, 2022
Introduction A major contributor to coronavirus disease 2019 (COVID‐19) progression and severity is a dysregulated innate and adaptive immune response. Interleukin‐38 (IL−38) is an IL‐1 family member with broad anti‐inflammatory properties, but thus far ...
de Graaf DM, Teufel LU, de Nooijer AH, van Gammeren AJ, Ermens AAM, Gaál IO, Crișan TO, van de Veerdonk FL, Netea MG, Dinarello CA, Joosten LAB, Arts RJW, Radboudumc Center for Infectious Diseases COVID-19 Study Group.   +12 more
europepmc   +2 more sources

Interleukin-38 Ameliorates Atherosclerosis by Inhibiting Macrophage M1-like Polarization and Apoptosis. [PDF]

Biomolecules
Objectives: As a novel member of the interleukin(IL)-1 family, IL-38 has shown therapeutic effects in various chronic inflammatory diseases. However, its role and underlying mechanisms in cardiovascular diseases, particularly atherosclerosis, remain ...
Li Z, Li X, Shen R, Wang Y, Yu J, Pan C, Cai Y, Dong Q, Yu K, Zeng Q.   +9 more
europepmc   +2 more sources

Prognostic value of interleukin-34 and interleukin-38 in patients with newly diagnosed atrial fibrillation. [PDF]

Front Cardiovasc Med, 2022
BackgroundInterleukin (IL)-34 and IL-38 are associated with cardiovascular disease (CVD). However, their involvement in atrial fibrillation (AF) and AF-associated adverse events remains uncertain. Therefore, we aimed to investigate their association with
Ma J, Wu N, Yuan Z, Chen Y, Li C, Xie W, Zhang Z, Li Y, Zhong L.   +8 more
europepmc   +2 more sources

Interleukin-38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2-p38 pathway-dependent manner. [PDF]

Physiol Rep, 2023
Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin‐38 (IL‐38) is a member of the IL‐
Kurose S, Matsubara Y, Yoshino S, Yoshiya K, Morisaki K, Furuyama T, Hoshino T, Yoshizumi T.   +7 more
europepmc   +2 more sources

The role of interleukin-37 and interleukin-38 in the development and remission of autism spectrum disorder: a comprehensive review of neuroinflammatory mechanisms and potential therapeutic implications. [PDF]

Front Immunol
Autism spectrum disorder (ASD) is a complicated neurodevelopmental syndrome characterized by abnormalities in social communication, lack of interests, and repetitive behaviors.
Al Rasbi Z, Orsud H, Zoughbor SH, Hajar M, Mahboob A, Sadek B.   +5 more
europepmc   +2 more sources

Interleukin-38 overexpression in keratinocytes limits desquamation but does not affect the global severity of imiquimod-induced skin inflammation in mice. [PDF]

Front Immunol
Psoriasis is a common chronic inflammatory skin disease that significantly impacts the patients’ quality of life. Recent studies highlighted the function of the interleukin (IL)-1 family member IL-38 in skin homeostasis and suggested an anti-inflammatory
Huard A, Rodriguez E, Talabot-Ayer D, Weigert A, Palmer G.   +4 more
europepmc   +2 more sources

The decreased serum levels of interleukin-38 in patients with gout and its clinical significance. [PDF]

Front Immunol
BackgroundInterleukin (IL)-38 is a newly discovered anti-inflammatory cytokine. However, its concentration and clinical significance in patients with gout remain unclear.
Huang H, Zhou Y, Li Y, Zhao H, Wu X, Li M.   +5 more
europepmc   +2 more sources

Important Roles of Interleukin-36, Interleukin-37, and Interleukin-38 Cytokines in the Pathogenesis of Rosacea.

Indian J Dermatol
Background: Rosacea is a chronic inflammatory skin disease. Previous studies have determined that IL-36, IL-37, and IL-38 may play a role in the pathogenesis of various inflammatory diseases.
Ekinci A, Kilic SO, Demir N, Siddikoglu D.   +3 more
europepmc   +2 more sources

Reduced interleukin-38 in non-small cell lung cancer is associated with tumour progression. [PDF]

Open Biol, 2018
Lung cancer continues to be the leading cause of cancer-related deaths worldwide due to its high incidence, malignant behaviour and lack of major advancements in treatment strategy.
Wang F, Zhang W, Wu T, Chu H.
europepmc   +2 more sources