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Circulating interleukin-38 concentrations in healthy adults [PDF]

Frontiers in Immunology, 2022
Interleukin (IL)-38 is the latest discovered member of the interleukin-1 family, which has anti-inflammatory properties similar to IL-36Ra. Several studies compared circulating IL-38 concentrations in healthy and diseased populations to characterize its ...
Lisa U. Teufel, Dennis M. de Graaf, Dennis M. de Graaf, Dennis M. de Graaf, Mihai G. Netea, Mihai G. Netea, Charles A. Dinarello, Charles A. Dinarello, Leo A. B. Joosten, Leo A. B. Joosten, Rob J. W. Arts   +10 more
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Exploratory analysis of interleukin‐38 in hospitalized COVID‐19 patients [PDF]

Immunity, Inflammation and Disease, 2022
Introduction A major contributor to coronavirus disease 2019 (COVID‐19) progression and severity is a dysregulated innate and adaptive immune response. Interleukin‐38 (IL−38) is an IL‐1 family member with broad anti‐inflammatory properties, but thus far ...
Dennis M. deGraaf, Lisa U. Teufel, Aline H. deNooijer, Adriaan J. vanGammeren, Antonius A. M. Ermens, Ildikó O. Gaál, Tania O. Crișan, Frank L. van deVeerdonk, Mihai G. Netea, Charles A. Dinarello, Leo A. B. Joosten, Rob J. W. Arts, the Radboudumc Center for Infectious Diseases COVID‐19 Study Group   +12 more
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Interleukin-38 Ameliorates Atherosclerosis by Inhibiting Macrophage M1-like Polarization and Apoptosis [PDF]

Biomolecules
Objectives: As a novel member of the interleukin(IL)-1 family, IL-38 has shown therapeutic effects in various chronic inflammatory diseases. However, its role and underlying mechanisms in cardiovascular diseases, particularly atherosclerosis, remain ...
Zhiyang Li, Xuelian Li, Rui Shen, Yue Wang, Jian Yu, Chengliang Pan, Yifan Cai, Qian Dong, Kunwu Yu, Qiutang Zeng   +9 more
doaj   +2 more sources

Prognostic value of interleukin-34 and interleukin-38 in patients with newly diagnosed atrial fibrillation [PDF]

Frontiers in Cardiovascular Medicine, 2023
BackgroundInterleukin (IL)-34 and IL-38 are associated with cardiovascular disease (CVD). However, their involvement in atrial fibrillation (AF) and AF-associated adverse events remains uncertain. Therefore, we aimed to investigate their association with
Jiaxue Ma, Na Wu, Na Wu, Zhiquan Yuan, Zhiquan Yuan, Yanxiu Chen, Chengying Li, Chengying Li, Weijia Xie, Weijia Xie, Zhihui Zhang, Yafei Li, Yafei Li, Li Zhong   +13 more
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Interleukin‐38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2‐p38 pathway‐dependent manner [PDF]

Physiological Reports, 2023
Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin‐38 (IL‐38) is a member of the IL‐
Shun Kurose, Yutaka Matsubara, Shinichiro Yoshino, Keiji Yoshiya, Koichi Morisaki, Tadashi Furuyama, Tomoaki Hoshino, Tomoharu Yoshizumi   +7 more
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Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors [PDF]

Cell Communication and Signaling
Background Interleukin (IL)-38 is an IL-1 family cytokine that was proposed to exert anti-inflammatory effects. However, its mechanisms of action are not well understood and the identity of the IL-38 receptor(s) remains debated.
Alejandro Diaz-Barreiro, Dominique Talabot-Ayer, Arnaud Huard, Gea Cereghetti, Jenna Tonacini, Mike Maillasson, Antonio Francés-Monerris, Erwan Mortier, Gaby Palmer   +8 more
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Interleukin-38 overexpression in keratinocytes limits desquamation but does not affect the global severity of imiquimod-induced skin inflammation in mice [PDF]

Frontiers in Immunology
Psoriasis is a common chronic inflammatory skin disease that significantly impacts the patients’ quality of life. Recent studies highlighted the function of the interleukin (IL)-1 family member IL-38 in skin homeostasis and suggested an anti-inflammatory
Arnaud Huard, Arnaud Huard, Arnaud Huard, Emiliana Rodriguez, Emiliana Rodriguez, Emiliana Rodriguez, Dominique Talabot-Ayer, Dominique Talabot-Ayer, Dominique Talabot-Ayer, Andreas Weigert, Gaby Palmer, Gaby Palmer, Gaby Palmer   +12 more
doaj   +2 more sources

The role of interleukin-37 and interleukin-38 in the development and remission of autism spectrum disorder: a comprehensive review of neuroinflammatory mechanisms and potential therapeutic implications [PDF]

Frontiers in Immunology
Autism spectrum disorder (ASD) is a complicated neurodevelopmental syndrome characterized by abnormalities in social communication, lack of interests, and repetitive behaviors.
Zakeya Al Rasbi, Hiba Orsud, Sumaya Hasan Zoughbor, Malak Hajar, Malak Hajar, Abdulla Mahboob, Bassem Sadek, Bassem Sadek   +7 more
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The decreased serum levels of interleukin-38 in patients with gout and its clinical significance [PDF]

Frontiers in Immunology
BackgroundInterleukin (IL)-38 is a newly discovered anti-inflammatory cytokine. However, its concentration and clinical significance in patients with gout remain unclear.
Hua Huang, Yinxin Zhou, Yan Li, Yan Li, Hui Zhao, Xiudi Wu, Mingcai Li, Mingcai Li   +7 more
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Important Roles of Interleukin-36, Interleukin-37, and Interleukin-38 Cytokines in the Pathogenesis of Rosacea

Indian Journal of Dermatology
Background: Rosacea is a chronic inflammatory skin disease. Previous studies have determined that IL-36, IL-37, and IL-38 may play a role in the pathogenesis of various inflammatory diseases.
Alper Ekinci, Sevilay O. Kilic, Nesrin Demir, Duygu Siddikoglu   +3 more
doaj   +2 more sources