Reduced interleukin-38 in non-small cell lung cancer is associated with tumour progression [PDF]
Open Biology, 2018 Lung cancer continues to be the leading cause of cancer-related deaths worldwide due to its high incidence, malignant behaviour and lack of major advancements in treatment strategy.
Feng Wang +3 more
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Neutralization of interleukin-38 exacerbates coxsackievirus B3-induced acute myocarditis in mice [PDF]
Virology Journal, 2021 Background Interleukin (IL)-38, a novel member of the IL-1 family, has been reported to be involved in several diseases associated with viral infection. However, the expression and functional role of IL-38 in acute viral myocarditis (AVMC) have not been ...
Yimin Xue +7 more
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Elevated serum interleukin-38 levels in polymyositis and dermatomyositis: diagnostic implications and correlations with inflammatory markers [PDF]
Frontiers in ImmunologyBackgroundInterleukin (IL)-38 has been recently identified as an anti-inflammatory cytokine. Polymyositis (PM) and dermatomyositis (DM) are two prevalent clinical inflammatory myopathies.
Wen Qin +9 more
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Interleukin-38: A Candidate Biomarker for Disease Severity in Advanced Steatotic Liver Disease [PDF]
CellsBackground: Interleukin-38 (IL-38) is an anti-inflammatory IL-1—family cytokine implicated in limiting tissue injury by its anti-inflammatory character. We evaluated the diagnostic discrimination and prognostic relevance in steatotic liver disease (SLD).
Valeria Wagner +8 more
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Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections [PDF]
Cell Death and Disease, 2021 Interleukin-38 has recently been shown to have anti-inflammatory properties in lung inflammatory diseases. However, the effects of IL-38 in viral pneumonia remains unknown.
Xun Gao +9 more
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Interleukin-38 is a negative regulator of trained immunity—A retrospective multi-omics study [PDF]
iScienceSummary: Trained immunity is a long-lasting innate immune cell phenotype with benefits in infection control and recognized anti-cancer effects. Conversely, inappropriately induced trained immunity contributes to pathological inflammation, warranting the ...
Lisa U. Teufel +12 more
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Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review [PDF]
Frontiers in Immunology, 2018 Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta,
Wang-Dong Xu, An-Fang Huang
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The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy [PDF]
Scientific Reports, 2017 Interleukin 38 (IL-38) is a novel identified cytokine of IL-1 family in which some members are important in inflammation and angiogenesis. However, the role of IL-38 in regulating angiogenesis is unknown.
Jing Zhang +9 more
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Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes. [PDF]
PLoS ONE, 2019 Interleukin (IL)-38 is a member of the IL-1 family of cytokines, which was proposed to exert anti-inflammatory effects. IL-38 is constitutively expressed in the skin, where keratinocytes are the main producing cells.
Dominique Talabot-Ayer +8 more
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Recombinant IL-38 Alleviates Temporomandibular Joint Synovial Inflammation via IL-1R1-NF-κB-IL1β Pathway [PDF]
International Dental JournalIntroduction and aims: Interleukin (IL)-38 has been identified as an anti-inflammatory cytokine; however, its specific role in temporomandibular joint (TMJ) synovial inflammation and the identity of its functional receptors remain elusive.
Ping Luo +3 more
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