Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes. [PDF]
PLoS One, 2019 Interleukin (IL)-38 is a member of the IL-1 family of cytokines, which was proposed to exert anti-inflammatory effects. IL-38 is constitutively expressed in the skin, where keratinocytes are the main producing cells.
Talabot-Ayer D +8 more
europepmc +8 more sources
Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review. [PDF]
Front Immunol, 2018 Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta,
Xu WD, Huang AF.
europepmc +6 more sources
Interleukin-38 and cardiovascular pathology: literature review [PDF]
КардиоСоматика, 2023 Cardiovascular pathology is a leading cause of morbidity and mortality. An important task of modern cardiology is the search and study of new biological markers. Scientists’ interest is actively focused on the study of interleukin-38.
Amina M. Alieva +4 more
doaj +3 more sources
Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors. [PDF]
Cell Commun SignalBackground Interleukin (IL)-38 is an IL-1 family cytokine that was proposed to exert anti-inflammatory effects. However, its mechanisms of action are not well understood and the identity of the IL-38 receptor(s) remains debated.
Diaz-Barreiro A +8 more
europepmc +4 more sources
Emerging Role of Interleukin-38 (IL-38) in the Development of Rheumatoid Arthritis
Rheumatology and TherapyIntroduction Rheumatoid arthritis (RA) is an incurable autoimmune disease. The role of interleukin-38 (IL-38), an anti-inflammatory cytokine, in RA is not fully understood, and its clinical relevance in RA remains unclear.
Shengxiang Liang +7 more
doaj +4 more sources
The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy. [PDF]
Sci Rep, 2017 Interleukin 38 (IL-38) is a novel identified cytokine of IL-1 family in which some members are important in inflammation and angiogenesis. However, the role of IL-38 in regulating angiogenesis is unknown.
Zhang J +9 more
europepmc +5 more sources
The Egyptian Journal of Internal MedicineBackground Interleukin (IL)-36α and IL-38, two novel cytokines of the IL-1 family, have recently been proposed to have a pathophysiological significance in type 2 diabetes mellitus (T2DM).
Shahad W. Nassurat +2 more
doaj +3 more sources
Serum interleukin 38 (IL-38) as a new potential biomarker of pediatric asthma
The Egyptian Journal of Bronchology, 2022 Background Bronchial asthma is considered the most prevalent chronic respiratory disease worldwide and is one of the main causes of hospitalization in the pediatric population.
Asmaa Kamal +3 more
doaj +2 more sources
Neutralization of interleukin-38 exacerbates coxsackievirus B3-induced acute myocarditis in mice. [PDF]
Virol J, 2021 Background Interleukin (IL)-38, a novel member of the IL-1 family, has been reported to be involved in several diseases associated with viral infection. However, the expression and functional role of IL-38 in acute viral myocarditis (AVMC) have not been ...
Xue Y +7 more
europepmc +2 more sources
Interleukin-38: A Candidate Biomarker for Disease Severity in Advanced Steatotic Liver Disease. [PDF]
CellsBackground: Interleukin-38 (IL-38) is an anti-inflammatory IL-1—family cytokine implicated in limiting tissue injury by its anti-inflammatory character. We evaluated the diagnostic discrimination and prognostic relevance in steatotic liver disease (SLD).
Wagner V +8 more
europepmc +2 more sources