Results 21 to 30 of about 417,438 (262)

Elevated serum interleukin-38 levels in polymyositis and dermatomyositis: diagnostic implications and correlations with inflammatory markers. [PDF]

Front Immunol
BackgroundInterleukin (IL)-38 has been recently identified as an anti-inflammatory cytokine. Polymyositis (PM) and dermatomyositis (DM) are two prevalent clinical inflammatory myopathies.
Qin W, Li Z, Fu G, Li Y, Huang W, Yu M, Wu X, Li M.   +7 more
europepmc   +2 more sources

Interleukin-38 is a negative regulator of trained immunity-A retrospective multi-omics study. [PDF]

iScience
Summary: Trained immunity is a long-lasting innate immune cell phenotype with benefits in infection control and recognized anti-cancer effects. Conversely, inappropriately induced trained immunity contributes to pathological inflammation, warranting the ...
Teufel LU, Matzaraki V, Folkman L, de Graaf DM, Horst RT, Moorlag SJCFM, Dos Santos JC, Mulders-Manders CM, Krausgruber T, Dinarello C, Netea MG, Joosten LAB, Arts RJW.   +12 more
europepmc   +2 more sources

Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections. [PDF]

Cell Death Dis, 2021
Interleukin-38 has recently been shown to have anti-inflammatory properties in lung inflammatory diseases. However, the effects of IL-38 in viral pneumonia remains unknown.
Gao X, Chan PKS, Lui GCY, Hui DSC, Chu IM, Sun X, Tsang MS, Chan BCL, Lam CW, Wong CK.   +9 more
europepmc   +2 more sources

Plasma levels of interleukin-38 in healthy aging and in type 2 diabetes

Diabetes Research and Clinical Practice, 2021
Plasma levels of interleukin (IL)-38 were evaluated in patients with type 2 diabetes (T2DM) and healthy controls. Plasma IL-38 was higher in T2DM patients and positively related to waist/hip ratio, HbA1c, uric acid, liver function tests, triglycerides ...
Gurău, Felicia, Rita Bonfigli, Anna, Olivieri, Fabiola, Sabbatinelli, Jacopo, Silvestrini, Andrea, Matacchione, Giulia, Fazioli, Francesca   +6 more
core   +3 more sources

The emerging role of IL‐38 in diseases: A comprehensive review

Immunity, Inflammation and Disease, 2023
Introduction Interleukin‐38 (IL‐38) is a new type of anti‐inflammatory cytokine, which is mainly expressed in the immunity‐related organs and is involved in various diseases including cardiovascular and cerebrovascular diseases, lung diseases, viral ...
Weijun Chen, Shuangyun Xi, Yong Ke, Yinlei Lei   +3 more
doaj   +2 more sources

Opposing Effects of Interleukin-36γ and Interleukin-38 on Trained Immunity. [PDF]

Int J Mol Sci, 2023
Trained immunity is the process of long-term functional reprogramming (a de facto innate immune memory) of innate immune cells such as monocytes and macrophages after an exposure to pathogens, vaccines, or their ligands. The induction of trained immunity is mediated through epigenetic and metabolic mechanisms.
Teufel LU, Netea MG, van de Veerdonk FL, Dinarello CA, Joosten LAB, Arts RJW.   +5 more
europepmc   +4 more sources

IL-38: A New Player in Inflammatory Autoimmune Disorders

Biomolecules, 2019
Interleukin (IL)-38, a newly discovered IL-1 family cytokine, is expressed in several tissues and secreted by various cells. IL-38 has recently been reported to exert an anti-inflammatory function by binding to several receptors, including interleukin-36
Lihui Xie, Zhaohao Huang, He Li, Xiuxing Liu, Song Guo Zheng, Wenru Su   +5 more
doaj   +2 more sources

Recombinant IL-38 Alleviates Temporomandibular Joint Synovial Inflammation via IL-1R1-NF-κB-IL1β Pathway. [PDF]

Int Dent J
Introduction and aims: Interleukin (IL)-38 has been identified as an anti-inflammatory cytokine; however, its specific role in temporomandibular joint (TMJ) synovial inflammation and the identity of its functional receptors remain elusive.
Luo P, Lv X, Hui J, Qiao H.
europepmc   +2 more sources

IL-38 as a Novel Biomarker in Multiple Myeloma Patients: A Prospective Clinical Evaluation

Cancer Management and Research
Hailan Shen, Ping Zhao, Ju Cao Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Ju Cao, Department of Laboratory Medicine, The First Affiliated Hospital
Shen H, Zhao P, Cao J
doaj   +2 more sources

Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3. [PDF]

Proc Natl Acad Sci U S A, 2022
Calcific aortic valve disease (CAVD) is common in people over the age of 65. Progressive valvular calcification is a characteristic of CAVD and due to chronic inflammation in aortic valve interstitial cells (AVICs) resulting in CAVD progression. IL-38 is a naturally occurring anti-inflammatory cytokine; here, we report lower levels of endogenous IL-38 ...
The E, de Graaf DM, Zhai Y, Yao Q, Ao L, Fullerton DA, Dinarello CA, Meng X.   +7 more
europepmc   +3 more sources