Results 11 to 20 of about 2,027,182 (132)

Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes [PDF]

PLOS ONE, 2019
Interleukin (IL)-38 is a member of the IL-1 family of cytokines, which was proposed to exert anti-inflammatory effects. IL-38 is constitutively expressed in the skin, where keratinocytes are the main producing cells. Little information is currently available concerning IL-38 biology.
Talabot Frischknecht-Ayer, Dominique, Mermoud, Loïc Xavier, Borowczyk, Julia, Drukala, Justyna, Wolnicki, Michal, Modarressi Ghavami, Seyed Ali, Boehncke, Wolf-Henning, Brembilla, Nicolo, Palmer-Lourenco, Gaby   +8 more
doaj   +8 more sources

Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review [PDF]

Frontiers in Immunology, 2018
Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta, heart, and brain.
Wang-Dong Xu, An-Fang Huang
doaj   +5 more sources

Interleukin-38 Ameliorates Atherosclerosis by Inhibiting Macrophage M1-like Polarization and Apoptosis [PDF]

Biomolecules
Objectives: As a novel member of the interleukin(IL)-1 family, IL-38 has shown therapeutic effects in various chronic inflammatory diseases. However, its role and underlying mechanisms in cardiovascular diseases, particularly atherosclerosis, remain unclear.
Zhiyang Li, Xuelian Li, Rui Shen, Yue Wang, Jian Yu, Chengliang Pan, Yifan Cai, Qian Dong, Kunwu Yu, Qiutang Zeng   +9 more
doaj   +6 more sources

Neutralization of interleukin-38 exacerbates coxsackievirus B3-induced acute myocarditis in mice [PDF]

Virology Journal, 2021
Abstract Background Interleukin (IL)-38, a novel member of the IL-1 family, has been reported to be involved in several diseases associated with viral infection. However, the expression and functional role of IL-38 in acute viral myocarditis (AVMC) have not been investigated. Methods
Yimin Xue, Mingguang Chen, Qian Chen, Tingfeng Huang, Qiaolian Fan, Fenghui Lin, Jun Ke, Feng Chen   +7 more
doaj   +4 more sources

The decreased serum levels of interleukin-38 in patients with gout and its clinical significance [PDF]

Frontiers in Immunology
BackgroundInterleukin (IL)-38 is a newly discovered anti-inflammatory cytokine. However, its concentration and clinical significance in patients with gout remain unclear. This study aimed to investigate the levels of IL-38 in patients with gout and evaluate their clinical significance.MethodsThirty-two patients with active gout, 27 patients with ...
Hua Huang, Yinxin Zhou, Yan Li, Yan Li, Hui Zhao, Xiudi Wu, Mingcai Li, Mingcai Li   +7 more
doaj   +5 more sources

Interleukin-38 is a negative regulator of trained immunity—A retrospective multi-omics study [PDF]

iScience
Trained immunity is a long-lasting innate immune cell phenotype with benefits in infection control and recognized anti-cancer effects. Conversely, inappropriately induced trained immunity contributes to pathological inflammation, warranting the exploration of regulatory pathways.
Teufel, L.U., Teufel, L.U., Matzaraki, V., Folkman, L., de Graaf, D.M., Horst, R.T., Moorlag, S.J.C.F.M., Dos Santos, J.C., Mulders-Manders, C.M., Krausgruber, T., Dinarello, C.A., Netea, M.G., Joosten, L.A.B., Arts, R.J.W.   +13 more
doaj   +8 more sources

Interleukin-38: A Candidate Biomarker for Disease Severity in Advanced Steatotic Liver Disease [PDF]

Cells
Background: Interleukin-38 (IL-38) is an anti-inflammatory IL-1—family cytokine implicated in limiting tissue injury by its anti-inflammatory character. We evaluated the diagnostic discrimination and prognostic relevance in steatotic liver disease (SLD). Methods: We conducted a prospective, monocentric cohort analysis of 184 patients with SLD (n = 176)
Valeria Wagner, Michael Mederer, Barbara Enrich, Veronika Cibulkova, Johanna Piater, Andreas Zollner, Rebecca Giquel-Fernandes, Herbert Tilg, Maria Effenberger   +8 more
doaj   +5 more sources

Important Roles of Interleukin-36, Interleukin-37, and Interleukin-38 Cytokines in the Pathogenesis of Rosacea [PDF]

Indian Journal of Dermatology
Background: Rosacea is a chronic inflammatory skin disease. Previous studies have determined that IL-36, IL-37, and IL-38 may play a role in the pathogenesis of various inflammatory diseases.
Alper Ekinci, Sevilay O. Kilic, Nesrin Demir, Duygu Siddikoglu   +3 more
doaj   +2 more sources

Interleukin‐38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2‐p38 pathway‐dependent manner [PDF]

Physiological Reports, 2023
Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin‐38 (IL‐38) is a member of the IL‐
Shun Kurose, Yutaka Matsubara, Shinichiro Yoshino, Keiji Yoshiya, Koichi Morisaki, Tadashi Furuyama, Tomoaki Hoshino, Tomoharu Yoshizumi   +7 more
doaj   +2 more sources

Prognostic value of interleukin-34 and interleukin-38 in patients with newly diagnosed atrial fibrillation [PDF]

Frontiers in Cardiovascular Medicine, 2023
BackgroundInterleukin (IL)-34 and IL-38 are associated with cardiovascular disease (CVD). However, their involvement in atrial fibrillation (AF) and AF-associated adverse events remains uncertain. Therefore, we aimed to investigate their association with
Jiaxue Ma, Na Wu, Na Wu, Zhiquan Yuan, Zhiquan Yuan, Yanxiu Chen, Chengying Li, Chengying Li, Weijia Xie, Weijia Xie, Zhihui Zhang, Yafei Li, Yafei Li, Li Zhong   +13 more
doaj   +2 more sources