Interleukin-38 overexpression in keratinocytes limits desquamation but does not affect the global severity of imiquimod-induced skin inflammation in mice [PDF]
Frontiers in ImmunologyPsoriasis is a common chronic inflammatory skin disease that significantly impacts the patients’ quality of life. Recent studies highlighted the function of the interleukin (IL)-1 family member IL-38 in skin homeostasis and suggested an anti-inflammatory
Arnaud Huard +12 more
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Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors [PDF]
Cell Communication and SignalingBackground Interleukin (IL)-38 is an IL-1 family cytokine that was proposed to exert anti-inflammatory effects. However, its mechanisms of action are not well understood and the identity of the IL-38 receptor(s) remains debated.
Alejandro Diaz-Barreiro +8 more
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The role of interleukin-37 and interleukin-38 in the development and remission of autism spectrum disorder: a comprehensive review of neuroinflammatory mechanisms and potential therapeutic implications [PDF]
Frontiers in ImmunologyAutism spectrum disorder (ASD) is a complicated neurodevelopmental syndrome characterized by abnormalities in social communication, lack of interests, and repetitive behaviors.
Zakeya Al Rasbi +7 more
doaj +2 more sources
Interleukin‐38 promotes skin tumorigenesis in an IL‐1Rrp2‐dependent manner [PDF]
The EMBO Reports, 2022 Interleukin-38 (IL-38) is strongly associated with chronic inflammatory diseases; however, its role in tumorigenesis is poorly understood. We demonstrated that expression of IL-38, which exhibits high expression in the skin, is downregulated in human cutaneous squamous cell carcinoma and 7,12-dimethylbenzanthracene/12-O-tetradecanoyl phorbol-13-acetate-
Hong Zhou +24 more
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Reduced interleukin-38 in non-small cell lung cancer is associated with tumour progression [PDF]
Open Biology, 2018 Lung cancer continues to be the leading cause of cancer-related deaths worldwide due to its high incidence, malignant behaviour and lack of major advancements in treatment strategy.
Feng Wang +3 more
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Elevated serum interleukin-38 levels in polymyositis and dermatomyositis: diagnostic implications and correlations with inflammatory markers [PDF]
Frontiers in ImmunologyBackgroundInterleukin (IL)-38 has been recently identified as an anti-inflammatory cytokine. Polymyositis (PM) and dermatomyositis (DM) are two prevalent clinical inflammatory myopathies.
Wen Qin +9 more
doaj +2 more sources
Interleukin-38 as a potential diagnostic biomarker for heart failure [PDF]
Biomarkers in MedicineInterleukin-38 (IL-38) attenuates inflammation, myocardial injury, and ventricular remodeling after myocardial infarction, which potentially reduces the incidence of heart failure (HF). This study aimed to evaluate the diagnostic value of IL-38 for HF.IL-38 was detected via enzyme-linked immunosorbent assay in the serum samples of 238 hF patients and ...
Hongman Liu +7 more
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Interleukin-38 promoter variants and risk of COVID-19 among Iraqis [PDF]
Immunobiology, 2022 Coronavirus disease-19 (COVID-19) has recently emerged as a respiratory infection with a significant impact on health and society. The pathogenesis is primarily attributed to a dysregulation of cytokines, especially those with pro-inflammatory and anti-inflammatory effects. Interleukin-38 (IL-38) is a recently identified anti-inflammatory cytokine with
Al-Karaawi, Ibtihal A. +3 more
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Elevated Interleukin-38 Level Associates with Clinical Response to Atorvastatin in Patients with Hyperlipidemia [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Hyperlipidemia is a risk factor for various cardiovascular and metabolic disorders. And it is tightly related to chronic inflammation. Interleukin-38 (IL-38) represents a new member of anti-inflammatory cytokines. Thus we studied the important role of IL-38 in hyperlipidemia development and treatment.
Ning Yang +6 more
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The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease [PDF]
Journal of Clinical Biochemistry and Nutrition, 2022 Interleukin (IL)-38 exerts an anti-inflammatory function by binding to several cytokine receptors, including the IL-36 receptor. In this study, we evaluated IL-38 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and investigated its functions.
Ohno, Masashi +7 more
openaire +4 more sources