Results 41 to 50 of about 1,897,702 (279)

Interleukin-38 is a negative regulator of trained immunity—A retrospective multi-omics study [PDF]

iScience
Summary: Trained immunity is a long-lasting innate immune cell phenotype with benefits in infection control and recognized anti-cancer effects. Conversely, inappropriately induced trained immunity contributes to pathological inflammation, warranting the ...
Lisa U. Teufel, Vasiliki Matzaraki, Lukas Folkman, Dennis M. de Graaf, Rob ter Horst, Simone J.C.F.M. Moorlag, Jéssica C. dos Santos, Catharina M. Mulders-Manders, Thomas Krausgruber, Charles Dinarello, Mihai G. Netea, Leo A.B. Joosten, Rob J.W. Arts   +12 more
doaj   +2 more sources

Higher Circulating Concentration of Interleukin-38 in Patients with Knee Osteoarthritis: Its Association with Disease Severity

Iranian Journal of Allergy, Asthma and Immunology, 2021
Evidence showed that chronic inflammatory and immunopathological responses play a pivotal role in the development of osteoarthritis (OA). Interleukin-38 (IL-38) as a novel anti-inflammatory cytokine with influential modulatory properties on both innate ...
Mitra Abassifard, Hossein Khorramdelazad, Shayan Rezaee, Abdollah Jafarzadeh   +3 more
doaj   +2 more sources

The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy [PDF]

Scientific Reports, 2017
Interleukin 38 (IL-38) is a novel identified cytokine of IL-1 family in which some members are important in inflammation and angiogenesis. However, the role of IL-38 in regulating angiogenesis is unknown.
Jing Zhang, Ruijuan Zhao, Jianping Chen, Jiayi Jin, Ying Yu, Yunzhe Tian, Weihua Li, Wencong Wang, Hongyan Zhou, Shao Bo Su   +9 more
doaj   +2 more sources

Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. [PDF]

Journal of Molecular Cell Biology, 2016
Different modes of cell death regulate immunity. Whereas necrotic (necroptotic, pyroptotic) cell death triggers inflammation, apoptosis contributes to its resolution. Interleukin-1 (IL-1) family cytokines are key players in this interaction. A number of IL-1 family cytokines are produced by necrotic cells to induce sterile inflammation.
Javier Mora, Andrea Schlemmer, I. Wittig, F. Richter, Mateusz Putyrski, Ann-Christin Frank, Ying-ying Han, M. Jung, Andreas M. Ernst, A. Weigert, B. Brüne   +10 more
semanticscholar   +3 more sources

Recombinant IL-38 Alleviates Temporomandibular Joint Synovial Inflammation via IL-1R1-NF-κB-IL1β Pathway [PDF]

International Dental Journal
Introduction and aims: Interleukin (IL)-38 has been identified as an anti-inflammatory cytokine; however, its specific role in temporomandibular joint (TMJ) synovial inflammation and the identity of its functional receptors remain elusive.
Ping Luo, Xueliang Lv, Jifang Hui, Hu Qiao   +3 more
doaj   +2 more sources

IL-38 as a Novel Biomarker in Multiple Myeloma Patients: A Prospective Clinical Evaluation [PDF]

Cancer Management and Research
Hailan Shen, Ping Zhao, Ju Cao Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Ju Cao, Department of Laboratory Medicine, The First Affiliated Hospital
Shen H, Zhao P, Cao J
doaj   +2 more sources

Interleukin-38 promotes tumor growth through regulation of CD8⁺ tumor-infiltrating lymphocytes in lung cancer tumor microenvironment. [PDF]

Cancer Immunol Immunother, 2021
Kinoshita F, Tagawa T, Akamine T, Takada K, Yamada Y, Oku Y, Kosai K, Ono Y, Tanaka K, Wakasu S, Oba T, Osoegawa A, Shimokawa M, Oda Y, Hoshino T, Mori M.   +15 more
europepmc   +2 more sources

Retraction ‘Reduced interleukin-38 in non-small cell lung cancer is associated with tumour progression’ [PDF]

Open Biology, 2020
Feng Wang, Weihua Zhang, Tianfeng Wu, Heying Chu   +3 more
doaj   +2 more sources

Imbalance of expression levels of IL-36γ and IL-38 is possibly associated with the severity of inflammation in psoriasis vulgaris

Pifu-xingbing zhenliaoxue zazhi, 2023
Objective To investigate the roles of cytokines, IL-36γ and IL-38, in the inflammatory response in psoriasis vulgaris. Methods Both serum and peripheral blood mononuclear cells (PBMC) were collected from 29 patients with psoriasis vulgaris (PV) and 19 ...
Jiao ZHANG, Liujun LU, Hang SU, Liyan YUAN, Yongfeng CHEN   +4 more
doaj   +1 more source

Anti-inflammatory Mechanisms of IL-38 in Chinese Patients with Allergic Rhinitis [PDF]

Iranian Journal of Immunology, 2023
Background: T-helper 17 (Th17) cell response is engaged in the onset of allergic rhinitis (AR). Moreover, interleukin (IL)-38 is thought to be involved in inhibiting cytokine secretion in the Th17 pathway.Objective: To evaluate the regulatory function of
Xiaoqiang Wang, Yang Shen, Xia Ke, Suling Hong   +3 more
doaj   +1 more source