IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells [PDF]
, 2019 Summary: Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is highly expressed in the skin and downregulated in psoriasis patients.
Billuart, Pierre +19 more
core +1 more source
Serum IL-38 levels in patients with type 2 diabetes mellitus [PDF]
, 2015 Introduction: Interleukin 38 (IL-38) is a new member of the IL-1 family, and it has anti-inflammatory activity. However, its role in type 2 diabetes mellitus (T2DM) has not been reported.
Li, Mingcai +3 more
core +2 more sources
Interleukin-34 promotes tumorigenic signals for colon cancer cells [PDF]
, 2021 Colorectal carcinoma (CRC) is one of the most common forms of malignancy in the Western world. Accumulating evidence indicates that colon carcinogenesis is tightly controlled by tumour-associated immune cells and stromal cells, which can either stimulate
Franze E. +4 more
core +1 more source
The emerging role of IL‐38 in diseases: A comprehensive review
Immunity, Inflammation and Disease, 2023 Introduction Interleukin‐38 (IL‐38) is a new type of anti‐inflammatory cytokine, which is mainly expressed in the immunity‐related organs and is involved in various diseases including cardiovascular and cerebrovascular diseases, lung diseases, viral ...
Weijun Chen +3 more
doaj +1 more source
The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases
Frontiers in Pharmacology, 2021 Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a
Miao-miao Han +12 more
doaj +1 more source
Assessment of IL-38 And IL-40 Levels in Gingival Crevicular Fluid in Gingivitis and Stage III Grade C Periodontitis: A Comparative Clinical Study [PDF]
Periodontal diseases are infections of the supporting apparatus of teeth caused by microbial agents, and cytokines have an important role in the inflammatory response.
Das, Dr. Neelam
core +2 more sources
IL-38: A New Player in Inflammatory Autoimmune Disorders
Biomolecules, 2019 Interleukin (IL)-38, a newly discovered IL-1 family cytokine, is expressed in several tissues and secreted by various cells. IL-38 has recently been reported to exert an anti-inflammatory function by binding to several receptors, including interleukin-36
Lihui Xie +5 more
doaj +1 more source
in-silico and in-vitro analysis of IL36RN mutations reveals critical residues for the function of the interleukin-36 receptor complex [PDF]
, 2023 Generalized pustular psoriasis (GPP) is a potentially life-threatening skin disease, associated with IL36RN mutations. IL36RN encodes the interleukin (IL)-36 receptor antagonist (IL-36Ra), a protein that downregulates the activity of IL-36 cytokines by ...
Capon, Francesca +9 more
core
Journal of Cosmetic Dermatology, 2021 Vitiligo is an acquired cutaneous depigmenting disease caused by a T helper (Th) 1–cytotoxic T cells driven autoimmune attack against melanocytes, in which Th17 is also involved.
Radwa El-Sayed Mahmoud Marie +3 more
semanticscholar +1 more source
IL‐38 attenuates myocardial ischemia–reperfusion injury by inhibiting macrophage inflammation
Immunity, Inflammation and Disease, 2023 Background Reperfusion therapy is the most effective approach to resolve coronary occlusion, but myocardial injury caused by excessive inflammation during myocardial ischemia–reperfusion will also pose a new threat to health. Our prior study revealed the
Yuzhen Wei +6 more
doaj +1 more source