Results 81 to 90 of about 1,897,702 (279)

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Interleukin-38 levels and haematological alterations in Giardiasis patients: A case-control study

Babcock University Medical Journal
Objective: Giardiasis, caused by the protozoan Giardia lamblia, remains a globally prevalent parasitic infection linked to considerable morbidity, especially in children.
Milad abdulkathem Lahmod, Murtada Hafedh Hussein   +1 more
doaj   +1 more source

Interleukin 38 reduces antigen-presentation capacity and antibody production after vaccination [PDF]

Vaccine
The mechanisms that underpin low vaccine responses, which can lead to inadequate protection against infection, are still partially unclear. Interleukin (IL)-38 is a member of the IL-1 family, expressed by B cells among others, that regulates inflammatory responses.
Teufel, L.U., Taks, E.J.M., Gemert, Jelle van, Neacsu, Mihaela, Fohse, Konstantin, Gillard, J.J., Diavatopoulos, D.A., Jonge, M.I. de, Netea, M.G., Joosten, L.A.B., Arts, R.J.W.   +10 more
openaire   +3 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Molecular aspects of Interleukin-36 cytokine activation and regulation [PDF]

Interleukin-36 (IL-36) cytokines are structurally similar to other Interleukin-1 superfamily members and are essential to convey inflammatory responses at epithelial barriers including the skin, lung, and gut. Due to their potent effects on immune cells,
Keller, Jennifer, Kündig, Thomas M, Mellett, Mark, O’ Siorain, James R   +3 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

IL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation

mAbs, 2023
Immune checkpoint inhibitors that overcome T cell suppressive mechanisms in tumors have revolutionized the treatment of cancer but are only efficacious in a small subset of patients.
John P. Dowling, Pavel A. Nikitin, Fang Shen, Halley Shukla, James P. Finn, Nirja Patel, Cezary Swider, Jamie L. Bingaman-Steele, Chris Nicolescu, Eden L Sikorski, Evan J. Greenawalt, Michael J. Morin, Matthew K. Robinson, Karen Lundgren, Benjamin C. Harman   +14 more
doaj   +1 more source

Viruses: Friends and Foes [PDF]

, 2017
In this chapter, we will review how viruses can be used to positively affect joints and cartilage of their hosts. Many viruses are arthrogenic, and cause persistent and debilitating arthritis.
Herrero, Lara J., Rudd, Penny A.
core   +2 more sources

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Interleukin-33 as a Potential Biomarker for Rheumatoid Arthritis: A Cross-Sectional Study [PDF]

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects about 1% of the general population. It is characterized by chronic, progressive, and systemic inflammation. Interleukin-33 (IL-33), is a pro-inflammatory cytokine that is
Alasady, Raad Abdulameer, Alsherees, Hashim Ali, Khamees, Mays Saleh   +2 more
core   +2 more sources