Results 31 to 40 of about 995,393 (179)

Exploratory analysis of interleukin‐38 in hospitalized COVID‐19 patients

Immunity, Inflammation and Disease, 2022
Introduction A major contributor to coronavirus disease 2019 (COVID‐19) progression and severity is a dysregulated innate and adaptive immune response. Interleukin‐38 (IL−38) is an IL‐1 family member with broad anti‐inflammatory properties, but thus far ...
Dennis M. deGraaf, Lisa U. Teufel, Aline H. deNooijer, Adriaan J. vanGammeren, Antonius A. M. Ermens, Ildikó O. Gaál, Tania O. Crișan, Frank L. van deVeerdonk, Mihai G. Netea, Charles A. Dinarello, Leo A. B. Joosten, Rob J. W. Arts, the Radboudumc Center for Infectious Diseases COVID‐19 Study Group   +12 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Circulating interleukin-38 concentrations in healthy adults

Frontiers in Immunology, 2022
Interleukin (IL)-38 is the latest discovered member of the interleukin-1 family, which has anti-inflammatory properties similar to IL-36Ra. Several studies compared circulating IL-38 concentrations in healthy and diseased populations to characterize its ...
Lisa U. Teufel, Dennis M. de Graaf, Dennis M. de Graaf, Dennis M. de Graaf, Mihai G. Netea, Mihai G. Netea, Charles A. Dinarello, Charles A. Dinarello, Leo A. B. Joosten, Leo A. B. Joosten, Rob J. W. Arts   +10 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Serum PYCARD may become a new diagnostic marker for rheumatoid arthritis patients

European Journal of Medical Research
Background The objective of this investigation is to analyze the levels and clinical relevance of serum PYCARD (Pyrin and CARD domain-containing protein, commonly known as ASC—apoptosis-associated speck-like protein containing a caspase activation and ...
Xue-Li Geng, Yong-Sen Jiang, Chun-Nan Zhao, Ze-Zhi Zhang, Yan-Ling Liu, Pei-Jian Ding   +5 more
doaj   +1 more source

Estimation of IL-8, IL-38, Vitamin D, TPO Ab, and CRP Levels in Iraqi Hashimoto Thyroiditis Patients

Medical Journal of Babylon
Background:Hashimoto’s disorder is an autoimmune disease affecting cells of the thyroid gland via the diffusion of the lymphocytes into thyroid cells. Calcitriol is the active form of Vit.D3; there were a strong correlation between low Vit-D levels and ...
Mayada Noori Iqbal, Jaleel Samanje
doaj   +1 more source

Neutralization of interleukin-38 exacerbates coxsackievirus B3-induced acute myocarditis in mice

Virology Journal, 2021
Background Interleukin (IL)-38, a novel member of the IL-1 family, has been reported to be involved in several diseases associated with viral infection. However, the expression and functional role of IL-38 in acute viral myocarditis (AVMC) have not been ...
Yimin Xue, Mingguang Chen, Qian Chen, Tingfeng Huang, Qiaolian Fan, Fenghui Lin, Jun Ke, Feng Chen   +7 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells

Cell Reports, 2019
Summary: Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is highly expressed in the skin and downregulated in psoriasis patients.
Yingying Han, Javier Mora, Arnaud Huard, Priscila da Silva, Svenja Wiechmann, Mateusz Putyrski, Christian Schuster, Eiman Elwakeel, Guangping Lang, Anica Scholz, Tatjana Scholz, Tobias Schmid, Natasja de Bruin, Pierre Billuart, Carlo Sala, Harald Burkhardt, Michael J. Parnham, Andreas Ernst, Bernhard Brüne, Andreas Weigert   +19 more
doaj   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source