Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review [PDF]
Journal of Inflammation ResearchYuan Xu, Jing-Yan Wang, Yang Zou, Xue-Wei Ma, Tian Meng College of Health Industry, Sichuan Tourism University, Chengdu, Sichuan, 610100, People’s Republic of ChinaCorrespondence: Yuan Xu, Email 230973159@qq.comAbstract: Inflammatory cytokines ...
Xu Y, Wang JY, Zou Y, Ma XW, Meng T
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The role of IL-36 and 37 in hepatocellular carcinoma [PDF]
Frontiers in ImmunologyHepatocellular carcinoma (HCC) has garnered considerable attention due to its morbidity and mortality. Although the precise mechanisms underlying HCC tumorigenesis remain to be elucidated, evidence suggests that host immunity plays a pivotal role in its ...
Juan Cao +7 more
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IL-37 and IL-36 Cytokine Profiles in Chronic Hepatitis Delta During Bulevirtide Therapy [PDF]
PathogensChronic hepatitis delta is the most severe form of viral hepatitis and is associated with rapid progression to cirrhosis and hepatocellular carcinoma. Although bulevirtide (BLV) effectively inhibits hepatitis D virus (HDV) entry, immunological biomarkers
Verdiana Zulian +6 more
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IL-17A-driven psoriasis is critically dependent on IL-36 signaling [PDF]
Frontiers in Immunology, 2023 Plaque psoriasis is an autoinflammatory and autoimmune skin disease, affecting 1-3% of the population worldwide. Previously, high levels of IL-36 family cytokines were found in psoriatic skin lesions, thereby contributing to keratinocyte ...
Berenice Fischer +13 more
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IL-36 is Closely Related to Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease [PDF]
International Journal of COPD, 2022 Siyuan Huang,1,* Tao Feng,2,* Jing Wang,1 Liang Dong3 1Department of Respiratory, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Respiratory Medicine, Shengli ...
Huang S, Feng T, Wang J, Dong L
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Dichotomous roles of IL-36 and IL-38 in cardiovascular disease [PDF]
Frontiers in ImmunologyMembers of the interleukin-1 (IL-1) superfamily play crucial roles in orchestrating inflammation and immune responses. Among them, IL-36 and IL-38 have emerged as cytokines with contrasting roles in cardiovascular disease (CVD).
Haifeng Zhang, Wenhui Huang, Shisan Bao
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The Role of IL-36 in Infectious Diseases: Potential Target for COVID-19? [PDF]
Frontiers in Immunology, 2021 IL-36 is a member of the interleukin 1 cytokine family, which is currently experiencing a renaissance due to the growing understanding of its context-dependent roles and advances in our understanding of the inflammatory response.
Xiaofang Wang +4 more
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IL-36 participated in airway remodeling in chronic asthma model by inducing epithelial–mesenchymal transition process [PDF]
European Journal of Medical ResearchPurpose Epithelial–mesenchymal transition (EMT) is a major pathological characteristic of airway remodelling in severe asthma. Interleukin (IL)-36 belongs to the IL-1 family and is associated with allergic disease, but the role of IL-36 in airway ...
Min Zhang +7 more
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IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic [PDF]
Frontiers in Immunology, 2022 Interleukin (IL)-36 cytokines are members of the IL-1 superfamily, which consists of three agonists (IL-36α, IL-36β and IL-36γ) and an IL-36 receptor antagonist (IL-36Ra). IL-36 cytokines are crucial for immune and inflammatory responses. Abnormal levels
Hongna Dong +4 more
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IL-36 activates neutrophil extracellular traps and exacerbates LPS-induced ARDS in mice [PDF]
Scientific ReportsSepsis-induced acute respiratory distress syndrome (ARDS) is characterized by uncontrolled pulmonary inflammation and neutrophil-driven pathology. Neutrophil extracellular traps (NETs) have been implicated in ARDS progression, but the role of interleukin-
Haiyan Hu +3 more
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