IL-36 cytokines in autoimmunity and inflammatory disease [PDF]
Oncotarget, 2017 The inteleukin-36 (IL-36) cytokines include IL-36α, IL-36β, IL-36γ and IL-36Ra, which belong to the IL-1 family and exert pro-inflammatory effects on various target cells such as keratinocytes, synoviocytes, dendritic cells and T cells. Emerging evidence has suggested a role of IL-36 in the pathogenesis of many inflammatory diseases. Here, we provide a
Ding, Liping +4 more
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IL-36 is Closely Related to Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease [PDF]
International Journal of COPD, 2022 Siyuan Huang,1,* Tao Feng,2,* Jing Wang,1 Liang Dong3 1Department of Respiratory, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Respiratory Medicine, Shengli ...
Huang S, Feng T, Wang J, Dong L
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The severity of experimental arthritis is independent of IL-36 receptor signaling [PDF]
Arthritis Research & Therapy, 2013 Abstract Introduction Interleukin (IL)-36 refers to three related IL-1 family cytokines, IL-36α, IL-36β, and IL-36γ, that bind to the IL-36 receptor (IL-36R). IL-36 exerts proinflammatory effects in skin and lung and stimulates T cell responses.
Lamacchia, Céline +8 more
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The Role of IL-36 in Infectious Diseases: Potential Target for COVID-19? [PDF]
Frontiers in Immunology, 2021 IL-36 is a member of the interleukin 1 cytokine family, which is currently experiencing a renaissance due to the growing understanding of its context-dependent roles and advances in our understanding of the inflammatory response.
Xiaofang Wang +4 more
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IL-36 participated in airway remodeling in chronic asthma model by inducing epithelial–mesenchymal transition process [PDF]
European Journal of Medical ResearchPurpose Epithelial–mesenchymal transition (EMT) is a major pathological characteristic of airway remodelling in severe asthma. Interleukin (IL)-36 belongs to the IL-1 family and is associated with allergic disease, but the role of IL-36 in airway ...
Min Zhang +7 more
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An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target [PDF]
Science Translational Medicine, 2017 IL-36 receptor (IL-36R) blockade ameliorates psoriatic inflammation and should be well tolerated, because IL-36R knockout mutations are benign.
Satveer K. Mahil +12 more
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IL-1α and IL-36 Family Cytokines Can Undergo Processing and Activation by Diverse Allergen-Associated Proteases [PDF]
Frontiers in Immunology, 2022 Inflammation driven by environmental allergens is an important source of morbidity in diseases such as asthma and eczema. How common allergens promote inflammation is still poorly understood, but previous studies have implicated the protease activity ...
Valentina Frezza +4 more
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IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist [PDF]
Proceedings of the National Academy of Sciences, 2012 The functional role of IL-1 family member 10, recently renamed IL-38, remains unknown. In the present study we aimed to elucidate the biological function of IL-38 and to identify its receptor. Heat-killed Candida albicans was used to stimulate memory T-lymphocyte cytokine production in freshly obtained human ...
Veerdonk, F.L. van de +10 more
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Biology of IL-36 cytokines and their role in disease
Seminars in Immunology, 2013 IL-36α, IL-36β, IL-36γ, and IL-36Ra, collectively called IL-36 cytokines, are part of the IL-1 family. IL-36α, IL-36β, and IL-36γ are IL-36 receptor (IL-36R) agonists, while IL-36Ra is a receptor antagonist that blocks the activation of IL-36R signaling.
Gresnigt, M.S., Veerdonk, F.L. van de
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The Significance of IL-36 Hyperactivation and IL-36R Targeting in Psoriasis [PDF]
International Journal of Molecular Sciences, 2019 Psoriasis is an immune-mediated inflammatory skin disease that involves mainly T helper (Th)17, Th1 and Th22 lymphocytes, which cause hyper-proliferation of the epidermis with aberrant differentiation of keratinocytes, and local production of chemokines and cytokines.
Madonna, S. +4 more
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