Results 1 to 10 of about 115,118 (303)

Flavonoids as inhibitors of human neutrophil elastase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Elastase is a proteolytic enzyme belonging to the family of hydrolases produced by human neutrophils, monocytes, macrophages, and endothelial cells.
Katarzyna Jakimiuk, Michal Tomczyk, Atanas G Atanasov   +2 more
exaly   +2 more sources

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

Journal of Cell Biology, 2010
Neutrophil elastase escapes azurophilic granules, translocates to the nucleus, and degrades histones to promote chromatin decondensation necessary for NET formation.
Arturo Zychlinsky, Venizelos Papayannopoulos, Abdul Hakkim   +2 more
exaly   +2 more sources

Screening of a hundred plant extracts as tyrosinase and elastase inhibitors, two enzymatic targets of cosmetic interest

Industrial Crops and Products, 2018
In search for natural products of cosmetic interest, a hundred plant extracts were in vitro tested against elastase and tyrosinase. The inhibitors of these enzymes find application as skin whitening, anti-ageing, anti-wrinkle agents as well as in the ...
Cinzia Sanna, Andrea Maxia, M Mandrone   +2 more
exaly   +2 more sources

Neutrophil elastase: From mechanisms to therapeutic potential

Journal of Pharmaceutical Analysis, 2023
Neutrophil elastase (NE), a major protease in the primary granules of neutrophils, is involved in microbicidal activity. NE is an important factor promoting inflammation, has bactericidal effects, and shortens the inflammatory process.
Weilin Zeng, Yingqiu Song, Runze Wang, Rong He, Tianlu Wang   +4 more
semanticscholar   +1 more source

SARS-CoV-2 Dysregulates Neutrophil Degranulation and Reduces Lymphocyte Counts

Biomedicines, 2022
SARS-CoV-2, the virus that causes COVID-19, has given rise to one of the largest pandemics, affecting millions worldwide. High neutrophil-to-lymphocyte ratios have been identified as an important correlate to poor recovery rates in severe COVID-19 ...
Abenaya Muralidharan, Todd A. Wyatt, St Patrick Reid   +2 more
doaj   +1 more source

Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

Cell, 2021
SUMMARY Cancer cell genetic variability and similarity to host cells has stymied development of broad anti-cancer therapeutics. Our innate immune system evolved to clear genetically diverse pathogens and limit host toxicity; however, whether/how innate ...
Chang Cui, Kasturi Chakraborty, X. Tang, Guo-Lin Zhou, K. Schoenfelt, Kristen M. Becker, Alexandria Hoffman, Ya-Fang Chang, Ariane Blank, C. Reardon, Hilary A. Kenny, T. Vaisar, E. Lengyel, G. Greene, L. Becker   +14 more
semanticscholar   +1 more source

Neutrophil Elastase and Chronic Lung Disease

Biomolecules, 2021
Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary disease, non-CF bronchiectasis, and bronchopulmonary dysplasia.
J. Voynow, M. Shinbashi
semanticscholar   +1 more source

Impact of Mt. Olympus Honeys on Virulence Factors Implicated in Pathogenesis Exerted by Pseudomonas aeruginosa

Antibiotics, 2023
The aim of this study was to examine the impact of twenty honey samples, harvested in Mt. Olympus (Greece), on the virulence factors implicated in P. aeruginosa pathogenesis.
Eleni Tsavea, Paraskevi Tzika, Eleni Katsivelou, Anna Adamopoulou, Marios Nikolaidis, Grigorios D. Amoutzias, Dimitris Mossialos   +6 more
doaj   +1 more source

Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model

Frontiers in Microbiology, 2021
Chronic infection by Pseudomonas aeruginosa in cystic fibrosis (CF) patients is a major contributor to progressive lung damage and is poorly treated by available antibiotic therapy.
Cristina Cigana, Jérôme Castandet, Nicolas Sprynski, Medede Melessike, Lilha Beyria, Serena Ranucci, Serena Ranucci, Beatriz Alcalá-Franco, Alice Rossi, Alessandra Bragonzi, Magdalena Zalacain, Martin Everett   +11 more
doaj   +1 more source

Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis

The FEBS Journal, 2021
Matrix metalloproteinase‐13 (MMP‐13) is a uniquely important collagenase that promotes the irreversible destruction of cartilage collagen in osteoarthritis (OA).
David J. Wilkinson, Adrian M. D. Falconer, H. L. Wright, Hua Lin, Kazuhiro Yamamoto, Kathleen Cheung, S. Charlton, Maria del Carmen Arques, S. Janciauskiene, R. Refaie, K. Rankin, D. Young, A. Rowan   +12 more
semanticscholar   +1 more source