Results 41 to 50 of about 115,118 (303)
Neutrophil elastase in the tumor microenvironment
Steroids, 2017 &NA; Myeloid cell production within the bone marrow is accelerated in the setting of cancer, and the numbers of circulating and infiltrating neutrophils and granulocytic myeloid derived suppressor cells (MDSCs) correlate with tumor progression and ...
I. Lerman, S. Hammes
semanticscholar +1 more source
The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension
Frontiers in Medicine, 2018 Pulmonary arterial hypertension (PAH) is a severe vasculopathy characterized by the presence of fibrotic lesions in the arterial wall and the loss of small distal pulmonary arteries.
Shalina Taylor +4 more
semanticscholar +1 more source
Local lung responses following endobronchial elastase and lipopolysaccharide instillation in sheep [PDF]
, 2006 Chronic lipopolysaccharide (LPS) exposure may contribute to the pathogenesis of a number of lung diseases including COPD and emphysema. We sought to develop a large-animal model of emphysema using repeated LPS administration into sheep lung segments.
Blundell, Richard +8 more
core +1 more source
Antioxidant and Antiaging Potential of Salak Fruit Extract (Salacca zalacca (Gaert.)Voss)
Majalah Obat Tradisional, 2023 Natural skin aging is indicated by a loss of skin structure and integrity caused by external factors including UV exposure. This exposure causes oxidative stress on skin cells, initiates aging, and degradation of extracellular matrix (ECM) structure ...
Wahyu Widowati +3 more
doaj +1 more source
Neutrophil Elastase Inhibitors and Chronic Kidney Disease
International Journal on Biological Sciences, 2018 End-stage renal disease (ESRD), the last stage of chronic kidney disease (CKD), is characterized by chronic inflammation and oxidative stress. Neutrophils are the front line cells that mediate an inflammatory response against microorganisms as they can ...
E. Bronze-da-Rocha, A. Santos-Silva
semanticscholar +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Frontiers in Cardiovascular Medicine, 2022 BackgroundAbdominal aortic aneurysm (AAA), characterized by a continued expansion of the aorta, leads to rupture if not surgically repaired. Mice aid the study of disease progression and its underlying mechanisms since sequential studies of aneurysm ...
Stephanie Morgan +18 more
doaj +1 more source
Neutrophil elastase in bronchiectasis
Respiratory Research, 2017 The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF.
A. Gramegna +8 more
semanticscholar +1 more source
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source
Cell Reports, 2014 Summary Neutrophils contain granules loaded with antimicrobial proteins and are regarded as impermeable organelles that deliver cargo via membrane fusion.
Kathleen D. Metzler +4 more
semanticscholar +1 more source