Results 1 to 10 of about 20,933 (225)

Immunoglobulin A protease from Sutterella wadsworthensis modifies outcome of infection with Campylobacter jejuni and is associated with microbiome diversity [PDF]

Gut Microbes
Sutterella wadsworthensis is an enigmatic member of the microbiota, previously reported to be present in healthy humans yet also associated with certain gut diseases and their therapeutic outcomes. Here, we report on S.
Marwan E. Majzoub, Fernando S. Santiago, Shreeya S. Raich, Prakruti Sirigeri, Isidora Simovic, Nicodemus Tedla, Nadeem O. Kaakoush   +6 more
doaj   +2 more sources

The FAM111A Gene: Genetic, Epigenetic, and Pharmacological Targets and Mechanistic Insights with Clinical Relevance [PDF]

Pharmaceuticals
Background/Objectives: FAM111A is a trypsin-like serine protease that has emerged as a regulator of DNA replication, and is directly related to genome stability, protein homeostasis, antiviral defense and cancer progression.
Kyriaki Hatziagapiou, Feneli Karachaliou, Trias Thireou, Eleni Koniari, Dimitrios Chaniotis, Apostolos Beloukas, Galateia Stathori, Panagiota Kafkaloudi, Bettina Krumbholz, George P. Chrousos, Louis Papageorgiou   +10 more
doaj   +2 more sources

Discovery and biochemical characterization of the D-aspartyl endopeptidase activity of the serine protease LACTB. [PDF]

J Biol Chem
Non-enzymatic D-isomerization of aspartic acid in proteins has been observed in lesions associated with age-related diseases, including cataracts and Alzheimer's disease. Given that D-isomerization of Asp disrupts the physiological conformation of proteins, it has been postulated that D-isomerization of Asp in proteins is a key factor in the ...
Ito G, Utsunomiya-Tate N.
europepmc   +3 more sources

Characteristics of the Intestine Extracts and Their Effect on the Crude Collagen Fibers of the Body Wall from Sea Cucumber Apostichopus japonicus

Biology, 2023
Sea cucumbers Apostichopus japonicus will vomit their intestines during certain stimulations, and the collagen of the body wall will then be degraded. To define the effect of the sea cucumber intestine extracts on the body wall, the intestinal extracts ...
Shi-Qi Xu, Zheng-Yu Zhang, Bin Nie, Yi-Nan Du, Yue Tang, Hai-Tao Wu   +5 more
doaj   +1 more source

Characterization of endopeptidases from the midgut of Morimus funereus (Coleoptera: Cerambycidae) larvae [PDF]

Archives of Biological Sciences, 2008
Application of specific chromogenic substrates, use of class-specific inhibitors, and zymogram analysis enabled us to identify several peptidase classes in extracts of the midgut of Morimus funereus larvae.
Božić Nataša, Dojnov Biljana, Milovanović Aleksandra, Nenadović Vera, Ivanović Jelisaveta, Vujčić Z.   +5 more
doaj   +1 more source

Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts [PDF]

, 2013
The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes.
A Mansukhani, AK Coussens, BD Stamper, BK Huang, BU Ang, C Owen, C Yao, CB Harvey, CH Shackleton, CW Li, D Gomez, D Johnson, DC Robinson, DP Rice, DT Gault, G Radetti, G Ramajayam, GA Brent, GM Morriss-Kay, GR Williams, H Kohara, H Miraoui, HJ Kim, J Connerney, J Esparza, J Zumbrunn, JA Greenwald, Jack C. Yu, James J. Cray, JH Bassett, JH Oh, JL Penfold, JM Britto, JQ Feng, JS Morey, K Kasono, KA Kapp-Simon, Kameron Khaksarfard, KM Lee, M Bodo, M Menking, M Segni, MH Sheng, MM Cohen Jr, Mohammed Elsalanty, PJ Marie, R Rice, S Akita, S Wadhwa, S Weiss, SA Boyadjiev, SA Rasmussen, Seth M. Weinberg, W Arlt, W Riggs Jr, WM Chadduck, Xing-Ming Shi, Y Xiong, Z von Marschall   +58 more
core   +10 more sources

Self Purification of Two Serine Endopeptidases [PDF]

Proceedings of the National Academy of Sciences, 1972
We have reported that a serine protease from Pronase, homologous with bovine chymotrypsin, is both active and stable in 6 M guanidinium chloride. The present investigation examined the possibility that this unique property might be used to permit the enzyme to engage in its own purification by cleaving companion proteins to low-molecular ...
W M, Awad, M S, Ochoa, T P, Toomey
openaire   +2 more sources

Fibroblast Activation Protein Specific Optical Imaging in Non-Small Cell Lung Cancer

Frontiers in Oncology, 2022
Fibroblast activation protein (FAP) is a cell surface propyl-specific serine protease involved in the regulation of extracellular matrix. Whilst expressed at low levels in healthy tissue, upregulation of FAP on fibroblasts can be found in several solid ...
Layla Mathieson, Layla Mathieson, Richard A. O’Connor, Richard A. O’Connor, Hazel Stewart, Paige Shaw, Kevin Dhaliwal, Kevin Dhaliwal, Gareth O. S. Williams, Alicia Megia-Fernandez, Ahsan R. Akram, Ahsan R. Akram, Ahsan R. Akram   +12 more
doaj   +1 more source

The role of lysosomal peptidases in glioma immune escape: underlying mechanisms and therapeutic strategies

Frontiers in Immunology, 2023
Glioblastoma is the most common primary malignant tumor of the central nervous system, which has the characteristics of strong invasion, frequent recurrence, and rapid progression.
Hao Liu, Hao Liu, Jie Peng, Jie Peng, Linzhen Huang, Dong Ruan, Yuguang Li, Fan Yuan, Zewei Tu, Zewei Tu, Zewei Tu, Zewei Tu, Kai Huang, Kai Huang, Kai Huang, Kai Huang, Xingen Zhu, Xingen Zhu, Xingen Zhu, Xingen Zhu   +19 more
doaj   +1 more source

Novel insights into plant defensin ingestion induced metabolic responses in the polyphagous insect pest Helicoverpa armigera

Scientific Reports, 2023
Lepidopteran insect pest Helicoverpa armigera is one of the most destructive pests of crop plants and several biotechnological approaches are being developed for its control.
Javed A. Mulla, Vaijayanti A. Tamhane
doaj   +1 more source