Results 21 to 30 of about 20,933 (225)

Action of Serine Carboxypeptidases on Endopeptidase Substrates, N-Acyldipeptideamides [PDF]

Bulletin of the Chemical Society of Japan, 1987
Abstract Action patterns of two serine carboxypeptidases, one from yeast (Y) and the other from wheat bran (W), on N-[3-(2-furyl)acryloyl]-(Fua-) dipeptideamide substrates were examined by HPLC and amino acid analysis. In the reaction of the wheat enzyme the substrates were hydrolyzed to Fua-amino acid and no sufficient amount of Fua ...
Shigeru Kunugi, Kazuo Tanabe, Kouji Yamashita, Mitsuhiro Fukuda   +3 more
openaire   +1 more source

The midgut transcriptome of Aedes aegypti fed with saline or protein meals containing chikungunya virus reveals genes potentially involved in viral midgut escape

BMC Genomics, 2017
Background The mosquito Aedes aegypti is the primary vector for medically important arthropod-borne viruses, including chikungunya virus (CHIKV). Following oral acquisition, an arbovirus has to persistently infect several organs in the mosquito before ...
Shengzhang Dong, Susanta K. Behura, Alexander W. E. Franz   +2 more
doaj   +1 more source

Modeling and structural analysis of PA clan serine proteases

BMC Research Notes, 2012
Background Serine proteases account for over a third of all known proteolytic enzymes; they are involved in a variety of physiological processes and are classified into clans sharing structural homology. The PA clan of endopeptidases is the most abundant
Laskar Aparna, Rodger Euan J, Chatterjee Aniruddha, Mandal Chhabinath   +3 more
doaj   +1 more source

Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus [PDF]

, 2015
Predatory Bdellovibrio bacteriovorus are natural antimicrobial organisms, killing other bacteria by whole-cell invasion. Self-protection against prey-metabolizing enzymes is important for the evolution of predation.
AA Russo, AJ McCoy, AK Fenton, C Grimm, C Lambert, C Lambert, C Lambert, C Vonrhein, D Abram, D Zhang, E Krissinel, EF Pettersen, F van den Ent, H Stolp, HC Berg, K Shatzkes, KJ Evans, L Holm, LC Crossman, MD Jacobs, MD Winn, MJ Capeness, MP Starr, NC Strynadka, P Emsley, PH Zwart, RE Sockett, RE Sockett, RP Joosten, S Al-Khodor, S Rendulic, TR Lerner, U Gophna, W Kabsch, X Pan, Z Pasternak, Z Pasternak   +36 more
core   +4 more sources

Biochemical Characterization of a Kunitz-Type Protease Inhibitor From Mimosa regnellii and Its Effects on Melanoma Cell Viability and Angiogenesis. [PDF]

Chem Biodivers
A Kunitz‐type serine protease inhibitor (JTI) purified from Mimosa regnellii seeds selectively targets melanoma cells. JTI triggers mitochondrial apoptosis, increases ROS and Ca2+ levels, arrests the cell cycle, and suppresses migration and angiogenesis without affecting healthy cells.
Rabêlo LMA, Cardoso PHO, Nobre LTDB, Dos Santos PIM, Lucena SV, Serquiz RP, Bemquerer MP, Rocha HAO, Nader HB, Dos Santos EA, de Oliveira AS, Frihling BEF, Migliolo L.   +12 more
europepmc   +2 more sources

Genetic Biodiversity and Posttranslational Modifications of Protease Serine Endopeptidase in Different Strains of Sordaria fimicola

BioMed Research International, 2023
Genetic variations (mutation, crossing over, and recombination) act as a source for the gradual alternation in phenotype along a geographic transect where the environment changes. Posttranslational modifications (PTMs) predicted modifications successfully in different and the same species of living organisms.
Uzma Naureen, Ahmed Nawaz Khosa, Muhammad Azfar Mukhtar, Fazul Nabi, Nisar Ahmed, Muhammad Saleem   +5 more
openaire   +2 more sources

MEPE-derived ASARM peptide inhibits odontogenic differentiation of dental pulp stem cells and impairs mineralization in tooth models of X-linked hypophosphatemia. [PDF]

PLoS ONE, 2013
Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X-chromosome) cause X-linked familial hypophosphatemic rickets (XLH), a disorder having severe bone and tooth dentin mineralization defects.
Benjamin Salmon, Claire Bardet, Mayssam Khaddam, Jiar Naji, Benjamin R Coyac, Brigitte Baroukh, Franck Letourneur, Julie Lesieur, Franck Decup, Dominique Le Denmat, Antonino Nicoletti, Anne Poliard, Peter S Rowe, Eric Huet, Sibylle Opsahl Vital, Agnès Linglart, Marc D McKee, Catherine Chaussain   +17 more
doaj   +1 more source

Genetic divergence between populations of feral and domestic forms of a mosquito disease vector assessed by transcriptomics [PDF]

PeerJ, 2015
Culex pipiens, an invasive mosquito and vector of West Nile virus in the US, has two morphologically indistinguishable forms that differ dramatically in behavior and physiology. Cx.
Dana C. Price, Dina M. Fonseca
doaj   +2 more sources

Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells [PDF]

, 2007
MMP-9 (matrix metalloproteinase 9) plays a critical role in tumour progression. Although the biochemical properties of the secreted form of proMMP-9 are well characterized, little is known about the function and activity of cell surface-associated proMMP-
Egea, Virginia, Jochum, Marianne, Mentele, Reinhard, Nagase, Hideaki, Pitsch, Thomas, Ries, Christian, Zahler, Stefan   +6 more
core   +1 more source

The genome of Strongyloides spp. gives insights into protein families with a putative role in nematode parasitism [PDF]

, 2016
SUMMARYParasitic nematodes are important and abundant parasites adapted to live a parasitic lifestyle, with these adaptations all aimed at facilitating their survival and reproduction in their hosts.
Hunt, Vicky L, Selkirk, Murray E, Tsai, Isheng J, Viney, Mark   +3 more
core   +2 more sources