BMC Genomics, 2017 Background The mosquito Aedes aegypti is the primary vector for medically important arthropod-borne viruses, including chikungunya virus (CHIKV). Following oral acquisition, an arbovirus has to persistently infect several organs in the mosquito before ...
Shengzhang Dong +2 more
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MEPE-derived ASARM peptide inhibits odontogenic differentiation of dental pulp stem cells and impairs mineralization in tooth models of X-linked hypophosphatemia. [PDF]
PLoS ONE, 2013 Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X-chromosome) cause X-linked familial hypophosphatemic rickets (XLH), a disorder having severe bone and tooth dentin mineralization defects.
Benjamin Salmon +17 more
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Crystal structures of trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes [PDF]
, 2013 Oligopeptidase B cleaves after basic amino acids in peptides up to 30 residues. As a virulence factor in bacteria and trypanosomatid pathogens that is absent in higher eukaryotes, this is a promising drug target.
Rory E Morty +15 more
core +1 more source
Genetic divergence between populations of feral and domestic forms of a mosquito disease vector assessed by transcriptomics [PDF]
PeerJ, 2015 Culex pipiens, an invasive mosquito and vector of West Nile virus in the US, has two morphologically indistinguishable forms that differ dramatically in behavior and physiology. Cx.
Dana C. Price, Dina M. Fonseca
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Sensitive substrates for neprilysin (neutral endopeptidase) and thermolysin that are highly resistant to serine proteases [PDF]
FEBS Letters, 1996 Tripeptide derivatives like 3‐carboxypropanoylalanyl‐alanyl‐leucine 4‐nitroanilide or 3‐carboxypropanoylalanyl‐alanyl‐phenylalanine 4‐nitroanilide are very sensitive substrates for neprilysin (k cat > 102 s−1; k cat/K m ≥ 106 s−1 · M−1) and are widely employed in investigations of the enzyme. However, these compounds are also good substrates for the
Spungin-Bialik, Anya +4 more
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Endopeptidases (kininases) are able to hydrolyze kinins in tubular fluid along the rat nephron
, 1999 The activities of serine endopeptidase, prolyl endopeptidase and neutral endopeptidase were determined in tubular fluid collected from several portions of the rat nephron as well as in urine.
R. C. R. Stella +3 more
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BMC Evolutionary Biology, 2011 Background Omptins are a family of outer membrane proteases that have spread by horizontal gene transfer in Gram-negative bacteria that infect vertebrates or plants.
Westerlund-Wikström Benita +3 more
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Purification and biochemical characterization of a vacuolar serine endopeptidase induced by glucose starvation in maize roots [PDF]
Biochemical Journal, 1996 An endopeptidase (designated RSIP, for root-starvation-induced protease) was purified to homogeneity from glucose-starved maize roots. The molecular mass of the enzyme was 59 kDa by SDS/PAGE under reducing conditions and 62 kDa by gel filtration on a Sephacryl S-200 column. The isoelectric point of RSIP was 4.55. The purified enzyme was stable, with no
F, James +4 more
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Action of Serine Carboxypeptidases on Endopeptidase Substrates, N-Acyldipeptideamides [PDF]
Bulletin of the Chemical Society of Japan, 1987 Abstract Action patterns of two serine carboxypeptidases, one from yeast (Y) and the other from wheat bran (W), on N-[3-(2-furyl)acryloyl]-(Fua-) dipeptideamide substrates were examined by HPLC and amino acid analysis. In the reaction of the wheat enzyme the substrates were hydrolyzed to Fua-amino acid and no sufficient amount of Fua ...
Shigeru Kunugi +3 more
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Using the SUBcellular database for Arabidopsis proteins to localize the Deg protease family
Frontiers in Plant Science, 2014 Sub-functionalization during the expansion of gene families in eukaryotes has occurred in part through specific subcellular localization of different family members.
Sandra Karin Tanz +7 more
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