Results 41 to 50 of about 122,475 (202)

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins [PDF]

, 2006
The human kallikrein locus on chromosome 19q13.3-13.4 contains kallikrein 1 - the tissue kallikrein - and 14 related serine proteases. Recent investigations into their function and evolution have indicated that the present nomenclature for these proteins
Scorilas, Andreas, Malm, Johan,, Talieri, M, Courty, Yves, Ulf-Håkan Stenman, Lundwall, Åke,, Yousef, George M, Georgia Sotiropoulou, Lois J. Maltais, Talieri, Maroulio, Olsson, A Yvonne, Yousef, George, Talieri, M., Malm, Johan, Carsten Stephan, Stephan, Carsten, Blaber, M., Liija, H., Malm, J., Fritz, Hans, Petraki, C, Scorilas, A, Diamandis, EP, Blaber, Michael, Clements, Judith A, Lundwall, A., Lilja, Hans, Andreas Scorilas, Scorilas, A., Olsson, A. Yvonne, Hans Fritz, Judith A. Clements, Clements, JA, Fritz, H., Lundwall, Åke, Constantina Petraki, Maltais, Lois J, Sotiropoulou, Georgia, Clements, J A, Clements, Judith, Lilja, H, Lund University., Blaber, M, Olsson, AY, Vimla Band, A. Yvonne Olsson, Lundwall, A, Band, Vimla, Maroulio Talieri, Stephan, C., Sotiropoulou, G, Lilja, Hans,, Yousef, G M, Petraki, Constantina, Courty, Y, Fritz, H, Sotiropoulou, G., Courty, Y., Eleftherios P. Diamandis, Maltais, LJ, Åke Lundwall, Michael Blaber, Yousef, GM, Diamandis, Eleftherios P, Hans Lilja, Stenman, Ulf-Hakan, Diamandis, E P, Maltais, L J, Stephan, C, Petraki, C., George M. Yousef, Stenman, UH, Malm, J, Band, V, Yves Courty, Olsson, A Y, Band, V., Maltais, Lois, Diamandis, Eleftherios, Johan Malm   +79 more
core   +1 more source

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

A human serine endopeptidase, purified with respect to activity against a peptide with phosphoserine in the P1' position, is apparently identical with prolyl endopeptidase

Journal of Biological Chemistry, 1991
The present work describes the detection, purification, and characterization of a serine endopeptidase with preference for a phosphoserine in the P1' position of the substrate. During probing for the enzyme in crude extracts, as well as during its 64,000-fold purification, 32P-labeled guanidovaleryl-Arg-Ala-Ser(P)-isobutyl amide (I) was used to measure
J, Rosén, B, Tomkinson, G, Pettersson, O, Zetterqvist   +3 more
openaire   +2 more sources

The family of Deg/HtrA proteases in plants

BMC Plant Biology, 2012
Background The Deg/HtrA family of ATP-independent serine endopeptidases is present in nearly all organisms from bacteria to human and vascular plants. In recent years, multiple deg/htrA protease genes were identified in various plant genomes.
Schuhmann Holger, Huesgen Pitter F, Adamska Iwona   +2 more
doaj   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Insights into the efficient degradation mechanism of extracellular proteases mediated by Purpureocillium lilacinum

Frontiers in Microbiology
Protease secretion is crucial for degrading nematode cuticles using nematophagous fungus Purpureocillium lilacinum, but the secretion pattern of protease remains poorly understood.
Xiujun Zhang, Yuhong Yang, Li Liu, Xin Sui, Ramon Santos Bermudez, Lushan Wang, Wenxing He, Huilian Xu   +7 more
doaj   +1 more source

The Role of Microbial Aspartic Protease Enzyme in Food and Beverage Industries

Journal of Food Quality, 2018
Proteases represent one of the three largest groups of industrial enzymes and account for about 60% of the total global enzymes sale. According to the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology, proteases are ...
Jermen Mamo, Fassil Assefa
doaj   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Serine-Modified Au@Cu₂O Core–Shell Nanoparticles for Catalysis-Mediated Colorimetric Detection of Small Molecules

, 2023
3,3′,5,5′-Tetramethylbenzidine (TMB)-based catalysis-mediated colorimetric analysis for the detection of small molecules has poor specificity. In this study, well-prepared Au@Cu2O core–shell nanocatalysts (NCs) were fabricated that have excellent ...
Wei-Peng Li (703383), Wen-Jyng Wang, Pei-Yu Wang (29615), Wen-Jyng Wang (16858748), Pei-Yu Wang, Wei-Peng Li   +5 more
core   +1 more source