Results 11 to 20 of about 16,013 (203)

Modeling and structural analysis of PA clan serine proteases

BMC Research Notes, 2012
Background Serine proteases account for over a third of all known proteolytic enzymes; they are involved in a variety of physiological processes and are classified into clans sharing structural homology. The PA clan of endopeptidases is the most abundant
Laskar Aparna, Rodger Euan J, Chatterjee Aniruddha, Mandal Chhabinath   +3 more
doaj   +2 more sources

Immunoglobulin A protease from Sutterella wadsworthensis modifies outcome of infection with Campylobacter jejuni and is associated with microbiome diversity [PDF]

Gut Microbes
Sutterella wadsworthensis is an enigmatic member of the microbiota, previously reported to be present in healthy humans yet also associated with certain gut diseases and their therapeutic outcomes. Here, we report on S.
Marwan E. Majzoub, Fernando S. Santiago, Shreeya S. Raich, Prakruti Sirigeri, Isidora Simovic, Nicodemus Tedla, Nadeem O. Kaakoush   +6 more
doaj   +2 more sources

The FAM111A Gene: Genetic, Epigenetic, and Pharmacological Targets and Mechanistic Insights with Clinical Relevance [PDF]

Pharmaceuticals
Background/Objectives: FAM111A is a trypsin-like serine protease that has emerged as a regulator of DNA replication, and is directly related to genome stability, protein homeostasis, antiviral defense and cancer progression.
Kyriaki Hatziagapiou, Feneli Karachaliou, Trias Thireou, Eleni Koniari, Dimitrios Chaniotis, Apostolos Beloukas, Galateia Stathori, Panagiota Kafkaloudi, Bettina Krumbholz, George P. Chrousos, Louis Papageorgiou   +10 more
doaj   +2 more sources

Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases

Molecules, 2018
The synthesis of racemic substituted 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one hydrochlorides was optimized to enhance reproducibility and increase the overall yield.
Emmanuel Salomon, Marjorie Schmitt, Anil Kumar Marapaka, Athanasios Stamogiannos, Germain Revelant, Céline Schmitt, Sarah Alavi, Isabelle Florent, Anthony Addlagatta, Efstratios Stratikos, Céline Tarnus, Sébastien Albrecht   +11 more
doaj   +2 more sources

Subunit III of ruminant procarboxypeptidase A‐S6 complexes and pancreatic proteases E a new family of pancreatic serine endopeptidases?

FEBS Letters, 1988
Subunit III (BSIII) of the bovine ternary complex of procarboxypeptidase A‐S6 (PCPA‐S6), a defective serine endopeptidase‐like protein, actively synthesized by the pancreas of some ruminant species, is highly homologous to human protease E (HPE). Both proteins possess the same atypical disulfide bridge in position 98–99b.
Cambillau, Christian, Kerfelec, Brigitte, Sciaky, Martine, Chapus, Catherine   +3 more
openaire   +3 more sources

CHANGES IN LEVELS OF ACTIVITY OF SERINE PROTEASES ACCOMPANY THE EXPOSURE OF COMMON BEAN (PHASEOLUS VULGARIS L.) TO WATER DEFICIT [PDF]

Poljoprivreda, 2008
A wide variety of proteolytic enzymes exist in plants. On their levels depends protein turnover, a fundamental component in plant development and adaptation to environmental conditions. Cysteine proteases have frequently been reported to be influenced by
M. Budič, M. Šoštarič, B. Cigić, M. Kidrič, V. Meglič   +4 more
doaj   +1 more source

Discovery and biochemical characterization of the D-aspartyl endopeptidase activity of the serine protease LACTB [PDF]

Journal of Biological Chemistry
Nonenzymatic D-isomerization of aspartic acid in proteins has been observed in lesions associated with age-related diseases, including cataracts and Alzheimer's disease. Given that D-isomerization of Asp disrupts the physiological conformation of proteins, it has been postulated that D-isomerization of Asp in proteins is a key factor in the ...
Genta Ito, Naoko Utsunomiya-Tate
openaire   +3 more sources

Plant-Programmed Cell Death-Associated Genes Participation in Pinus sylvestris L. Trunk Tissue Formation

Plants, 2022
Molecular genetic markers of various PCD (programmed cell death) variants during xylo- and phloemogenesis have been identified for the first time in Scots pine under lingonberry pine forest conditions in Northwest Russia (middle taiga subzone).
Yulia L. Moshchenskaya, Natalia A. Galibina, Kseniya M. Nikerova, Tatiana V. Tarelkina, Maksim A. Korzhenevsky, Irina N. Sofronova, Maria A. Ershova, Ludmila I. Semenova   +7 more
doaj   +1 more source

Homologous inhibitors from potato tubers of serine endopeptidases and metallocarboxypeptidases. [PDF]

Proceedings of the National Academy of Sciences, 1976
A potent polypeptide inhibitor of chymotrypsin has been purified from Russett Burbank potatoes. The inhibitor has no effect on bovine carboxypeptidases A or B but exhibits homology with a carboxypeptidase inhibitor that is also present in potato tubers.
C M, Hass, R, Venkatakrishnan, C A, Ryan
openaire   +2 more sources

Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios. [PDF]

PLoS ONE, 2013
Proprotein convertases (PCs) is a protein family which includes nine highly specific subtilisin-like serine endopeptidases in mammals. The system of PCs is involved in carcinogenesis and levels of PC mRNAs alter in cancer, which suggests expression ...
Ilya V Demidyuk, Andrey V Shubin, Eugene V Gasanov, Alexander M Kurinov, Vladimir V Demkin, Tatyana V Vinogradova, Marina V Zinovyeva, Alexander V Sass, Irina B Zborovskaya, Sergey V Kostrov   +9 more
doaj   +1 more source