Results 11 to 20 of about 16,131 (131)

The midgut transcriptome of Aedes aegypti fed with saline or protein meals containing chikungunya virus reveals genes potentially involved in viral midgut escape

BMC Genomics, 2017
Background The mosquito Aedes aegypti is the primary vector for medically important arthropod-borne viruses, including chikungunya virus (CHIKV). Following oral acquisition, an arbovirus has to persistently infect several organs in the mosquito before ...
Shengzhang Dong, Susanta K. Behura, Alexander W. E. Franz   +2 more
doaj   +1 more source

Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios. [PDF]

PLoS ONE, 2013
Proprotein convertases (PCs) is a protein family which includes nine highly specific subtilisin-like serine endopeptidases in mammals. The system of PCs is involved in carcinogenesis and levels of PC mRNAs alter in cancer, which suggests expression ...
Ilya V Demidyuk, Andrey V Shubin, Eugene V Gasanov, Alexander M Kurinov, Vladimir V Demkin, Tatyana V Vinogradova, Marina V Zinovyeva, Alexander V Sass, Irina B Zborovskaya, Sergey V Kostrov   +9 more
doaj   +1 more source

Modeling and structural analysis of PA clan serine proteases

BMC Research Notes, 2012
Background Serine proteases account for over a third of all known proteolytic enzymes; they are involved in a variety of physiological processes and are classified into clans sharing structural homology. The PA clan of endopeptidases is the most abundant
Laskar Aparna, Rodger Euan J, Chatterjee Aniruddha, Mandal Chhabinath   +3 more
doaj   +1 more source

MEPE-derived ASARM peptide inhibits odontogenic differentiation of dental pulp stem cells and impairs mineralization in tooth models of X-linked hypophosphatemia. [PDF]

PLoS ONE, 2013
Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X-chromosome) cause X-linked familial hypophosphatemic rickets (XLH), a disorder having severe bone and tooth dentin mineralization defects.
Benjamin Salmon, Claire Bardet, Mayssam Khaddam, Jiar Naji, Benjamin R Coyac, Brigitte Baroukh, Franck Letourneur, Julie Lesieur, Franck Decup, Dominique Le Denmat, Antonino Nicoletti, Anne Poliard, Peter S Rowe, Eric Huet, Sibylle Opsahl Vital, Agnès Linglart, Marc D McKee, Catherine Chaussain   +17 more
doaj   +1 more source

An IscS Persulfide Donates the Sulfur for Ribosomal Protein uL16 Thioamidation

Angewandte Chemie, EarlyView.
YcaO‐catalyzed thioamidation of the ribosomal subunit protein uL16 is widespread in Pseudomonadota bacteria. We identify the iron–sulfur cluster cysteine desulfurase IscS as the sulfur donor via an IscS persulfide and observe direct IscS–uL16 interactions.
Yanqing Xue, Markus W. Voehler, Douglas A. Mitchell   +2 more
wiley   +2 more sources

Genetic divergence between populations of feral and domestic forms of a mosquito disease vector assessed by transcriptomics [PDF]

PeerJ, 2015
Culex pipiens, an invasive mosquito and vector of West Nile virus in the US, has two morphologically indistinguishable forms that differ dramatically in behavior and physiology. Cx.
Dana C. Price, Dina M. Fonseca
doaj   +2 more sources

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

Molecular adaptation of a plant-bacterium outer membrane protease towards plague virulence factor Pla

BMC Evolutionary Biology, 2011
Background Omptins are a family of outer membrane proteases that have spread by horizontal gene transfer in Gram-negative bacteria that infect vertebrates or plants.
Westerlund-Wikström Benita, Laakkonen Liisa, Haiko Johanna, Korhonen Timo K   +3 more
doaj   +1 more source

Using the SUBcellular database for Arabidopsis proteins to localize the Deg protease family

Frontiers in Plant Science, 2014
Sub-functionalization during the expansion of gene families in eukaryotes has occurred in part through specific subcellular localization of different family members.
Sandra Karin Tanz, Ian eCastleden, Cornelia M Hooper, Ian eSmall, Ian eSmall, A. Harvey eMillar, A. Harvey eMillar, A. Harvey eMillar   +7 more
doaj   +1 more source

Insights into the keratin efficient degradation mechanism mediated by Bacillus sp. CN2 based on integrating functional degradomics

Biotechnology for Biofuels and Bioproducts, 2023
Background Keratin, the main component of chicken feather, is the third most abundant material after cellulose and chitin. Keratin can be converted into high-value compounds and is considered a potential high-quality protein supplement; However, its ...
Yuhong Lai, Xiuyun Wu, Xianliang zheng, Weiguang Li, Lushan Wang   +4 more
doaj   +1 more source