Leukocyte elastase, a1-proteinase inhibitor, and autoantibodies to neuroantigens in diagnostics of endogenous depressive disorders [PDF]
European Psychiatry, 2022 Introduction It has been suggested that the activation of systemic inflammatory response in depression is associated with inflammatory changes in the brain (neuroinflammation) and may reflect the severity of the clinical symptoms in patients ...
Z. Sarmanova +4 more
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Effects of leukocyte elastase in semen on sperm quality. [PDF]
Medicine (Baltimore), 2022 The study analyzed the effect of leukocyte elastase (LE) in 460 semen on sperm quality, and explore the reference interval of normal level of LE in semen. The differences of LE levels between normal semen and few, weak and abnormal semen were analyzed. Referring to domestic standards, the samples were divided into normal group (LE ≤ 250 ng/mL), occult ...
Wang Q, Que C, Chen G.
europepmc +3 more sources
Association of leukocyte elastase in semen and seminal plasma with sperm parameters and pregnancy outcomes in male fertility [PDF]
Endocrine ConnectionsBackground: Semen analysis is the standard test for evaluating male fertility. However, it may not address all aspects of male infertility. This review explores the role of leukocyte elastase (LE) as a possible biomarker for male fertility by evaluating ...
Mausumi Das +6 more
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The hidden side of SERPINB1/Leukocyte Elastase Inhibitor.
Semin Cell Dev Biol, 2017 SERPINB1, also called Leukocyte Elastase Inhibitor (LEI) is a member of the clade B of SERPINS. It is an intracellular protein and acts primarily to protect the cell from proteases released into the cytoplasm during stress. Its role in inflammation is clear due to its involvement in the resolution of chronic inflammatory lung and bowel diseases.
Torriglia A, Martin E, Jaadane I.
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Human eosinophils lack human leukocyte elastase
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 1996 Recently, human leukocyte elastase has been detected in human eosinophils. Reinvestigating these findings, 2.5 pg active human leukocyte elastase (E.C. 3.4.21.37) were found per neutrophil isolated from peripheral blood, whereas the elastase activity of eosinophil preparations was linearly correlated with the content of contaminating neutrophils.
V Streit, O Wiedow
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Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2′ site binding inhibitor [PDF]
Acta Crystallographica Section F, Structural Biology Communications, 2018 Karsten Niefind +2 more
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A BODIPY-Tagged Phosphono Peptide as Activity-Based Probe for Human Leukocyte Elastase [PDF]
ACS Medicinal Chemistry Letters, 2018 Michael Gutschow
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Tranilast ameliorates experimental abdominal aortic aneurysm by inhibiting the NLRP3 inflammasome pathway [PDF]
Journal of Pharmaceutical AnalysisAn abnormal inflammatory response is one of the main pathogenic mechanisms of abdominal aortic aneurysms (AAAs), and tranilast, an antiallergic drug, has anti-inflammatory properties.
Haole Liu +20 more
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Frontiers in Cardiovascular Medicine, 2023 AimSignal transducer and activator of transcription (STAT) signaling is critical for the pathogenesis of abdominal aortic aneurysms (AAAs). Though protein inhibitor of activated STAT3 (PIAS3) negatively modulates STAT3 activity, but its role in AAA ...
Weilai Fu +15 more
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Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia
Scientific Reports, 2021 Bacterial and viral respiratory infections can initiate acute lung injury and acute respiratory distress syndrome. Neutrophils and their granule enzymes, including neutrophil elastase, are key mediators of the pathophysiology of acute respiratory failure.
Hisanori Domon +5 more
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