Results 41 to 50 of about 123,303 (240)

The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis

Frontiers in Cell and Developmental Biology, 2021
Leukocyte invasion (neutrophils and monocytes/macrophages) is closely related to the severity of acute pancreatitis (AP) and plays an important role in the systemic inflammatory response and other organ injuries secondary to AP.
Jianhua Wan, Yuping Ren, Xiaoyu Yang, Xueyang Li, Liang Xia, Nonghua Lu   +5 more
doaj   +1 more source

Human Leukocyte Elastase Induces Keratinocyte Proliferation In Vitro and In Vivo [PDF]

, 2002
Neutrophil infiltration and epidermal hyperproliferation are major histopathologic changes observed in psoriasis. Neutrophils contain human leukocyte elastase, which is thought to be released during neutrophil infiltration of the epidermis.
Proksch, Ehrhardt, Wiedow, Oliver, Meyer-Hoffert, Ulf, Rogalski, Christina   +3 more
core   +1 more source

Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood

Journal of Pregnancy, 2012
Preeclampsia (PE) is one of the main causes of maternal and fetal mortality and morbidity. PE is associated with an inflammatory state and with oxidative stress, in maternal circulation.
Cristina Catarino, Alice Santos-Silva, Luís Belo, Petronila Rocha-Pereira, Susana Rocha, Belmiro Patrício, Alexandre Quintanilha, Irene Rebelo   +7 more
doaj   +1 more source

Temporal and Quantitative Analysis of Aortic Immunopathologies in Elastase-Induced Mouse Abdominal Aortic Aneurysms

Journal of Immunology Research, 2021
Objective. Elastase-induced abdominal aortic aneurysm (AAA) model is widely used for aneurysmal pathogenesis and translational research. However, temporal alternations in aneurysmal histologies remain unknown.
Kangli Tian, Congcong Xia, Haole Liu, Boyu Xu, Panpan Wei, Weilai Fu, Ming Lu, Yankui Li, Yafeng Li, Daxin Cheng, Enqi Liu, Sihai Zhao   +11 more
doaj   +1 more source

Development of Immature CD4+CD8+T Cells Into Mature CD4+ T Cells Requires Alpha-1 Antitrypsin as Observed by Treatment in HIV-1 Infected and Uninfected Controls

Frontiers in Cell and Developmental Biology, 2019
Immune cells are, by default, migratory cells that traverse tissue for the purpose of carrying out recognition and recruitment in pathologic inflammation and infection.
Cynthia L. Bristow, Cynthia L. Bristow, Sara Ferrando-Martinez, Sara Ferrando-Martinez, Ezequiel Ruiz-Mateos, Manuel Leal, Ronald Winston, Ronald Winston   +7 more
doaj   +1 more source

Phileucin - A Cyclic Dipeptide Similar to Phevalin (Aureusimine B) from M1146

Natural Product Communications, 2017
Overexpression of a putative type III polyketide synthase (PKSIII) from the marine myxobacterium Enhygromyxa salina SWB007 in Streptomyces coelicolor M1146 led to the accumulation of a novel monoketopiperazine consisting of phenylalanine and isoleucine ...
Nils Böhringer, Michael Gütschow, Gabriele M. König, Till F. Schäberle   +3 more
doaj   +1 more source

Neutrophil elastase ameliorates matrix metalloproteinase-9 to promote lipopolysaccharide-induced acute lung injury in mice 1 [PDF]

Acta Cirúrgica Brasileira, 2016
PURPOSE: To investigate the regulatory roles of neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP-9) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice.
Yingfei Guo, Lingyun Ma, Fei Zhang, Rongju Sun, Tanshi Li   +4 more
doaj   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Plasmin Inhibitors Prevent Leukocyte Accumulation and Remodeling Events in the Postischemic Microvasculature [PDF]

, 2011
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Nina Berberich, Rehberg, Markus, Wymann, Matthias P., Wymann, M. P., Uhl, B., Lerchenberger, Max, Uhl, Bernd, Berberich, Nina, Reichel, Christoph A., Bernd Uhl, Markus Rehberg, Matthias P. Wymann, Zahler, Stefan, Reichel, C. A., Uhl Bernd, Berberich Nina, Krombach Fritz, Lerchenberger, M., Stefan Zahler, Reichel Christoph A., Berberich, N., Fritz Krombach, Rehberg Markus, Zahler, S., Christoph A. Reichel, Krombach, Fritz, Max Lerchenberger, Krombach, F., Lerchenberger Max, Zahler Stefan, Matthias P Wymann, Rehberg, M., Christoph A Reichel, Wymann Matthias P.   +33 more
core   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source