Results 61 to 70 of about 123,303 (240)

Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria

American Journal of Hematology, EarlyView.
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho, Hasrini Rini, Noy N. Kambuaya, Syawal Satria, Freis Candrawati, Putu A. I. Shanti, King Alexander, Benediktus Andries, Aisah R. Amelia, Anjana Rai, Kim A. Piera, Agatha M. Puspitasari, Ristya Amalia, Pak Prayoga, Leo Leonardo, Maulina Hafidzah, Theo Situmorang, Dewi S. Margayani, Desandra A. Rahmayenti, Pengxing Cao, Enny Kenangalem, Leily Trianty, Damian Oyong, Julie A. Simpson, Rintis Noviyanti, Pierre A. Buffet, Jeanne R. Poespoprodjo, Nicholas M. Anstey   +27 more
wiley   +1 more source

IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

Mediators of Inflammation, 1998
The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is
U. Westin, E. Lundberg, K. Ohlsson
doaj   +1 more source

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, EarlyView.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice. [PDF]

PLoS ONE, 2016
Obesity-associated diseases such as Type 2 diabetes, liver disease and cardiovascular diseases are profoundly mediated by low-grade chronic inflammation of the adipose tissue. Recently, the importance of neutrophils and neutrophil-derived myeloperoxidase
Quinte Braster, Carlos Silvestre Roig, Helene Hartwig, Linda Beckers, Myrthe den Toom, Yvonne Döring, Mat J Daemen, Esther Lutgens, Oliver Soehnlein   +8 more
doaj   +1 more source

Myeloperoxidase/paraoxonase ratio as a prognostic marker for post-COVID syndrome in patients undergoing hemodialysis: A cross-sectional cohort study

Український Журнал Нефрології та Діалізу, 2023
The present study aimed to assess the impact of post-COVID syndrome on the oxidative status and activity of paraoxonase 1 (PON-1), myeloperoxidase (MPO), and leukocyte elastase in the blood of patients undergoing hemodialysis (HD). Methods.
L. Korol, N. Stepanova, O. Popova, N. Malashevska, V. Vasylchenko, T. Ostapenko, A. Rysyev, M. Kolesnyk   +7 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Role of Proteases in Chronic Obstructive Pulmonary Disease

Frontiers in Pharmacology, 2017
Chronic obstructive pulmonary disease (COPD) is generally associated with progressive destruction of airways and lung parenchyma. Various factors play an important role in the development and progression of COPD, like imbalance of proteases ...
Kailash C. Pandey, Sajal De, Pradyumna K. Mishra   +2 more
doaj   +1 more source

Betaine‐, xylitol‐, and extra virgin olive oil–based toothpaste modulates inflammation and oral nitric oxide pathway: Clinical trial in gingivitis

Journal of Periodontology, EarlyView.
Abstract Background Gingivitis is a prevalent and reversible inflammatory condition driven by microbial dysbiosis. Beyond plaque control, interest has grown in oral hygiene formulations capable of modulating inflammation while preserving key microbial functions. Extra virgin olive oil (EVOO), together with xylitol and betaine, has demonstrated clinical
Francisco Mesa, Alejandro Rodríguez‐Agurto, Marco Bonilla, Debora Rodríguez‐Vilaboa, Beatriz Rodríguez‐Vilaboa, Manuel Bravo   +5 more
wiley   +1 more source

Secretory leucocyte protease inhibitor regulates bone metabolism and inflammation in experimental mouse periodontitis

Communications Biology
Periodontitis is characterized by the activity of neutrophil elastase, a host defense factor that leads to the destruction of the epithelial barrier and bacterial invasion of the periodontal tissue.
Karin Sasagawa, Hisanori Domon, Satoru Hirayama, Tomoki Maekawa, Toshihito Isono, Koichi Tabeta, Yutaka Terao   +6 more
doaj   +1 more source

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture‐Induced Sepsis and the Ameliorating Effects of Adipose‐Derived Stem Cell Exosomes

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Shao‐Chun Wu, Tsu‐Hsiang Lu, Yi‐Chan Wu, Chia‐Wei Lin, Chia‐Wen Tsai, Ching‐Hua Hsieh   +5 more
wiley   +1 more source