Results 81 to 90 of about 123,303 (240)

Platelets modulate multiple markers of neutrophil function in response to in vitro Toll-like receptor stimulation.

PLoS ONE, 2019
INTRODUCTION:In addition to their role in facilitating leukocyte-mediated inflammation, platelets can dampen leukocyte pro-inflammatory responses in some contexts.
Kathryn E Hally, Georgina K Bird, Anne C La Flamme, Scott A Harding, Peter D Larsen   +4 more
doaj   +1 more source

Leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and Akt

, 2004
During acute inflammation, neutrophil-mediated injury to epithelium may lead to disruption of epithelial function, including the induction of epithelial apoptosis.
Hong, Ouyang, Vachon, Eric, Abreu, Maria Teresa Herrera, Moraes, Theo, Chow, Chung-Wai, Ginzberg, Hedy H, Suzuki, Tomoko, Cherepanov, Vera, Downey, Gregory P, Shannon, Patrick T, Wang, Xiaomin   +10 more
core   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

S1 Guideline: Therapy of generalized pustular psoriasis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The S1 guideline “Therapy of generalized pustular psoriasis (GPP)” is a German guideline developed in accordance with the criteria of the AWMF. The full version addresses clinical presentation, pathogenesis, diagnosis and differential diagnosis, comorbidities, and therapy.
Rotraut Mößner, Neda Cramer, Sascha Gerdes, Ulrike Hüffmeier, Andreas Körber, Kai Krause, Christian Kromer, Katharina Antonia Langen, Sandra Philipp, Knut Schäkel, Michael P. Schön, Michael Schultheis, Lukas Sollfrank, Petra Staubach, Michael Sticherling, Johannes Wohlrab, Dagmar Wilsmann‐Theis, Cornelia Paul   +17 more
wiley   +1 more source

Absence of Elastase in Human and Rabbit Leukocytes*

Journal of Investigative Dermatology, 1967
Histological sections of inflammatory tissues frequently show loss of elastic tissue staining (1). With one exception (2), however, there has been no demonstration of a mammalian elastase outside of the pancreas (3). Tissues that have been subjected to such treatment as irradiation, freeze-thawing, burning, and other types of trauma known to cause ...
Chotiner, Gerald, Smith, J. Graham, Rosett, Theodore   +2 more
openaire   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Human blood granulocyte degranulation and lysis intensity during interaction with Yersinia pestis in the ex vivo model of bacteriemia

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Considering the decisive role of antibacterial strategies of secretory degranulation and NETosis in the prevention of sepsis, it is of interest to study the interaction of Yersinia pestis with human blood granulocytes using an ex vivo ...
Aleksandr L. Kravtsov, Svetlana A. Bugorkova, Svetlana N. Klyueva, Tatyana P. Shmelkova, Vitaly A. Kozhevnikov   +4 more
doaj   +1 more source

2-Amino- and 2-Alkylthio-4H-3,1-benzothiazin-4-ones: Synthesis, Interconversion and Enzyme Inhibitory Activities

Molecules, 2009
The synthetic access to 2-sec-amino-4H-3,1-benzothiazin-4-ones 2 was explored. Compounds 2 were available from methyl 2-thioureidobenzoates 1, 2-thioureidobenzoic acids 3, and novel 2-thioureidobenzamides 6, respectively, under different conditions.
Hans-Georg Häcker, Florian Grundmann, Friederike Lohr, Philipp A. Ottersbach, Jing Zhou, Gregor Schnakenburg, Michael Gütschow   +6 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

ACE-inhibition prevents postischemic coronary leukocyte adhesion and leukocyte-dependent reperfusion injury [PDF]

, 1997
Objective: Polymorphonuclear leukocytes (PMN), retained in the microvascular bed, can contribute to postischemic myocardial reperfusion injury. Since a beneficial effect of ACE-inhibition on reperfusion injury has been reported, we investigated the ...
Weber, Christian, Messmer, Konrad, Habazettl, Helmut, Kupatt, Christian, Gerlach, Eckehart, Zahler, Stefan, Becker, Bernhard F., C Kupatt   +7 more
core   +1 more source