Results 11 to 20 of about 123,303 (240)
Isolation and Characterization of Porcine Leukocyte Elastase. Leukocyte Elastase-Inhibitor Complexes in Porcine Blood, II [PDF]
Clinical Chemistry and Laboratory Medicine, 1985 Porcine leukocyte elastase was purified from granulocytes by chelating chromatography on copper chelate Sepharose and by ion exchange chromatography on CM-Sepharose. Thus an enzyme preparation with a specific activity (substrate: MeOSuc(Ala)2ProValNan) of 89.3 U/mg protein was obtained.
Geiger, R., Junk, Anni, Jochum, Marianne
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Inhibitors of pancreatic and leukocyte elastase
Collection of Czechoslovak Chemical Communications, 1987 The following alkylamides of ω-carboxyalkanoyldi- and tripeptides of the Ala-Pro or Ala-Ala-Pro sequence have been prepared: ethylamide-, propylamide-, and isobutylamide of 3-carboxypropionylalanyl-proline, ethylamide of 3-carboxypropionylalanyl-alanyl-proline and ethylamide-, propylamide, and isobutylamide of 4-carboxybutyrylalanyl-alanyl-proline. The
Evžen Kasafírek +3 more
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Reperfusion-induced leukocyte infiltration: role of elastase
American Journal of Physiology-Heart and Circulatory Physiology, 1990 Polymorphonuclear leukocytes are known to accumulate in tissues subjected to ischemia and reperfusion. Studies on endothelial cell monolayers suggest that limited release of elastase plays an important role, via basement membrane degradation, in the leukocyte diapedesis and extravasation elicited by proinflammatory mediators.
B J, Zimmerman, D N, Granger
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Enantioselective inhibition of human leukocyte elastase
Archives of Biochemistry and Biophysics, 1992 (RS)-Diethyl-2-benzyl-succinate was resolved using alpha-chymotrypsin. The two enantiomers were then elaborated to yield (S)-(+) and (R)-(-)-3-benzyl-N-[(methyl-sulfonyl)oxy]succinimide and the inhibitory activity of the two enantiomers toward human leukocyte elastase was subsequently determined.
Groutas, William C. +3 more
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Effects of leukocyte elastase in semen on sperm quality. [PDF]
Medicine (Baltimore), 2022 The study analyzed the effect of leukocyte elastase (LE) in 460 semen on sperm quality, and explore the reference interval of normal level of LE in semen. The differences of LE levels between normal semen and few, weak and abnormal semen were analyzed. Referring to domestic standards, the samples were divided into normal group (LE ≤ 250 ng/mL), occult ...
Wang Q, Que C, Chen G.
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New phytoweapons to curb leukocyte elastase
Drugs of the Future, 2006 This review does not presume to be exhaustive in the field of leukocyte elastase inhibitors. Instead, a general picture will be sketched to give the reader a brief update and encourage advances in this continuously growing sector of pharmacology, drug discovery and drug design.
DELL'AICA I +3 more
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Shear Stress Induces the Release of an Endothelial Elastase: Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release [PDF]
, 2011 Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes.
Hennig, Theres +9 more
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Total hip and knee replacement surgery results in changes in leukocyte and endothelial markers
Journal of Inflammation, 2010 Background It is estimated that over 8 million people in the United Kingdom suffer from osteoarthritis. These patients may require orthopaedic surgical intervention to help alleviate their clinical condition. Investigations presented here was to test the
Maclean Kirsty M +5 more
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Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase [PDF]
, 1986 The neutrophil has been implicated as an important mediator of vascular injury, especially after endotoxemia. This study examines neutrophil-mediated injury to human microvascular endothelial cells in vitro. We found that neutrophils stimulated by formyl-
M G Tonnesen +15 more
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Trappin ovine molecule (TOM), the ovine ortholog of elafin, is an acute phase reactant in the lung [PDF]
, 2004 As large animal models continue to play an important role in translating lung-directed therapeutic strategies from laboratory animals to humans, there is an increasing interest in the analysis of endogenous regulators of inflammation at both a genomic ...
Collie, D David +4 more
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