Results 41 to 50 of about 1,058,192 (273)

IL-36 cytokines in autoimmunity and inflammatory disease

open access: yesOncotarget, 2017
The inteleukin-36 (IL-36) cytokines include IL-36α, IL-36β, IL-36γ and IL-36Ra, which belong to the IL-1 family and exert pro-inflammatory effects on various target cells such as keratinocytes, synoviocytes, dendritic cells and T cells. Emerging evidence has suggested a role of IL-36 in the pathogenesis of many inflammatory diseases. Here, we provide a
Ding, Liping   +4 more
openaire   +3 more sources

Consideration of serum IL‐36α and β levels trends in two patients with chikungunya fever

open access: yesClinical Case Reports, 2023
Key Clinical Message IL‐36 might play a role as an initial immune mechanism against chikungunya fever, and regulating IL‐36 production could be a potential treatment approach for this condition. Abstract Two Japanese siblings visited Cook Islands in 2015
Makoto Kondo   +5 more
doaj   +1 more source

Role of interleukin-36 in kidney disease

open access: yesLinchuang shenzangbing zazhi, 2023
As an important member of IL-1 family, interleukin 36 (IL-36) is a key regulator of inflammation. Its proinflammatory agonists are composed of IL-36α, IL-36β and IL-36γ while its antagonists include IL-36Ra and IL-38.
Bi-xia Yang, Hua Zhou, Min Yang
doaj   +1 more source

Review of the “Routledge Handbook of Philosophy of Sex and Sexuality”

open access: yesPhilosophies, 2023
This paper is a review essay of the recently published Routledge Handbook of Philosophy of Sex and Sexuality, edited by Brian D. Earp, Clare Chambers, and Lori Watson (2022). The anthology consists of an introduction and 40 essays, and it has eight parts:
Raja Halwani
doaj   +1 more source

The Origin and Development of Prison Fellowship International: Pluralism, Ecumenism and American Leadership in the Evangelical World 1974–2006 [PDF]

open access: yes, 2017
Established in 1979 by Watergate felon Charles Colson, Prison Fellowship International (PFI) is now one of the largest para-church organizations in world evangelicalism.
Kendrick Oliver
core   +2 more sources

IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis

open access: yesFrontiers in Immunology, 2019
The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals.
Erin Fahey   +4 more
doaj   +1 more source

Comparative Analysis of Single-Cell Transcriptome Data Reveals a Novel Role of Keratinocyte-Derived IL-23 in Psoriasis

open access: yesFrontiers in Immunology, 2022
Psoriasis, a common inflammatory skin disease, is critically dependent on the IL-23/IL-17 cytokine axis. Although immune cell-derived IL-23 is generally associated with the disease pathogenesis, there have been reports of IL-23 production in ...
Young Joon Park   +3 more
doaj   +1 more source

Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis

open access: yesActa Dermato-Venereologica, 2017
Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. The therapeutic response to biologics supports the pivotal role of the tumour necrosis alpha (TNF-?)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these ...
Kazuhisa Furue   +8 more
doaj   +1 more source

Designed DNA-Encoded IL-36 Gamma Acts as a Potent Molecular Adjuvant Enhancing Zika Synthetic DNA Vaccine-Induced Immunity and Protection in a Lethal Challenge Model

open access: yesVaccines, 2019
Identification of novel molecular adjuvants which can boost and enhance vaccine-mediated immunity and provide dose-sparing potential against complex infectious diseases and for immunotherapy in cancer is likely to play a critical role in the next ...
Lumena Louis   +5 more
doaj   +1 more source

Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage [PDF]

open access: yesThe Journal of Immunology, 2016
Abstract IL-1 family members are central mediators of host defense. In this article, we show that the novel IL-1 family member IL-36γ was expressed during experimental colitis and human inflammatory bowel disease. Germ-free mice failed to induce IL-36γ in response to dextran sodium sulfate (DSS)-induced damage, suggesting that gut ...
Oscar Medina-Contreras   +16 more
openaire   +2 more sources

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