Results 31 to 40 of about 5,139,608 (255)

IL-36 family cytokines in protective versus destructive inflammation

Cellular Signalling, 2020
The IL-1 family of cytokines and receptors are critical regulators of inflammation. Within the IL-1 family and in contrast to its IL-1 and IL-18 subfamilies, the IL-36 subfamily is still poorly characterized. Three pro-inflammatory agonists IL-36α, IL-36β, IL-36γ, one IL-36 receptor (IL-1R6) antagonist, IL-36RA, and one putative IL-1R6 antagonist, IL ...
Yingying Han, Arnaud Huard, Javier Mora, Priscila da Silva, Bernhard Brüne, Andreas Weigert   +5 more
openaire   +3 more sources

IL-37 and IL-36 Cytokine Profiles in Chronic Hepatitis Delta During Bulevirtide Therapy [PDF]

Pathogens
Chronic hepatitis delta is the most severe form of viral hepatitis and is associated with rapid progression to cirrhosis and hepatocellular carcinoma. Although bulevirtide (BLV) effectively inhibits hepatitis D virus (HDV) entry, immunological biomarkers
Verdiana Zulian, Martina De Sanctis, Silvia Pauciullo, Roberta Sciamanna, Eleonora Cimini, Paola Del Porto, Anna Rosa Garbuglia   +6 more
doaj   +2 more sources

Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis

Drug Design, Development and Therapy, 2019
Jing Guo,1,* Jie Tu,1,* YingYing Hu,1,2,* GuoXin Song,3 ZhiQiang Yin1 1Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 2Department of Medical Cosmetology, Wuqing People’s Hospital ...
Guo J, Tu J, Hu YY, Song GX, Yin ZQ
doaj   +1 more source

Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases [PDF]

Frontiers in Immunology, 2019
Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes.
Zhi-Chao Yuan, Wang-Dong Xu, Xiao-Yan Liu, Xing-You Liu, An-Fang Huang, Lin-Chong Su   +5 more
doaj   +3 more sources

IL-36 a new member of the IL-1 family cytokines.

Journal of biological regulators and homeostatic agents, 2012
Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-36 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases.
TRIPODI, Domenico, CONTI, FIORELLA, Rosati M, Maccauro G, Saggini A, CIANCHETTI, Ettore, Angelucci D, FULCHERI, Mario, Tetè S, SALINI, VINCENZO, Caraffa A, Antinolfi P, TONIATO, ELENA, Castellani ML, CONTI, Pio, Theoharides T.C.   +15 more
core   +8 more sources

Targeting IL-36 in Inflammatory Skin Diseases

Targeting IL-36 in Inflammatory Skin Diseases
Interleukin (IL)-36 cytokines are members of the IL-1 superfamily of cytokines. IL-36 cytokines are composed of three agonists (IL-36α, IL-36β, and IL-36γ) and two antagonists (IL-36 receptor antagonist [IL36Ra] and IL-38). These work in innate and acquired immunity and are known to contribute to host defense and to the pathogenesis of autoinflammatory
Akiyama, Masashi, Fukaura, Ryo
openaire   +1 more source

The Role of IL-36 in the Pathophysiological Processes of Autoimmune Diseases. [PDF]

Front Pharmacol, 2021
A member of the interleukin (IL)-1 superfamily was IL-36, which contained IL-36α, IL-36β, IL-36γ, and IL-36Ra. Heterotrimer complexes, consisting of heterodimeric receptor complexes and IL-36 agonist, gave signals through intracellular functional domains, so as to bind to downstream proteins and induce inflammatory response.
Chen WJ, Yu X, Yuan XR, Chen BJ, Cai N, Zeng S, Sun YS, Li HW.   +7 more
europepmc   +5 more sources

IL-36 in chronic inflammation and fibrosis - bridging the gap? [PDF]

J Clin Invest, 2021
IL-36 is a member of the IL-1 superfamily and consists of three agonists and one receptor antagonist (IL-36Ra). The three endogenous agonists, IL-36α, -β, and -γ, act primarily as proinflammatory cytokines, and their signaling through the IL-36 receptor (IL-36R) promotes immune cell infiltration and secretion of inflammatory and chemotactic molecules ...
Elias M, Zhao S, Le HT, Wang J, Neurath MF, Neufert C, Fiocchi C, Rieder F.   +7 more
europepmc   +4 more sources

The new external drug for the treatment of psoriasis based on inhibition of serine proteases

Vestnik Dermatologii i Venerologii, 2021
Background: Psoriasis is a chronic inflammatory immune-mediated disease characterized by an increased rate of keratinocyte division. The results of recent studies have made it possible to establish that the cytokines of the IL-36 family occupy a ...
Alexander S. Zhukov, Evgeny R. Zharun, Vladislav R. Khairutdinov, Alexey V. Samtsov, Mihail Yu. Krasavin, A. V. Garabagiou   +5 more
doaj   +1 more source

IkBζ is a Key Regulator of Tumour Necrosis Factor-a and Interleukin-17A-mediated Induction of Interleukin-36g in Human Keratinocytes

Acta Dermato-Venereologica, 2021
The interleukin (IL)-36 cytokine family plays an essential role in inflammatory processes in the skin and is implicated in the pathogenesis of psoriasis. This study explored the role of IL-36 in psoriasis and investigated the molecular mechanism involved
Sofie Kaas Ovesen, Klaus Schulze-Osthoff, Lars Iversen, Claus Johansen   +3 more
doaj   +1 more source