Results 31 to 40 of about 6,730,703 (222)

Role of interleukin-36 in kidney disease

open access: yesLinchuang shenzangbing zazhi, 2023
As an important member of IL-1 family, interleukin 36 (IL-36) is a key regulator of inflammation. Its proinflammatory agonists are composed of IL-36α, IL-36β and IL-36γ while its antagonists include IL-36Ra and IL-38.
Bi-xia Yang, Hua Zhou, Min Yang
doaj   +1 more source

Serum Dysregulation of IL-36, IL-37, and IL-38 in Pyoderma Gangrenosum: Clinical Correlations and Implications for IL-36R-Targeted Therapy. [PDF]

open access: yesInt J Mol Sci
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by chronic, painful ulcerations. Despite increasing evidence suggesting immunological dysregulation, the role of IL-36 cytokines in PG remains poorly defined.
Łyko M   +5 more
europepmc   +2 more sources

Comparative Analysis of Single-Cell Transcriptome Data Reveals a Novel Role of Keratinocyte-Derived IL-23 in Psoriasis

open access: yesFrontiers in Immunology, 2022
Psoriasis, a common inflammatory skin disease, is critically dependent on the IL-23/IL-17 cytokine axis. Although immune cell-derived IL-23 is generally associated with the disease pathogenesis, there have been reports of IL-23 production in ...
Young Joon Park   +3 more
doaj   +1 more source

IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis

open access: yesFrontiers in Immunology, 2019
The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals.
Erin Fahey   +4 more
doaj   +1 more source

Review of the “Routledge Handbook of Philosophy of Sex and Sexuality”

open access: yesPhilosophies, 2023
This paper is a review essay of the recently published Routledge Handbook of Philosophy of Sex and Sexuality, edited by Brian D. Earp, Clare Chambers, and Lori Watson (2022). The anthology consists of an introduction and 40 essays, and it has eight parts:
Raja Halwani
doaj   +1 more source

Study the Effect of Interleukin36 Gamma and AMH in Iraqi Women with PCOS

open access: yesAl-Mustansiriyah Journal of Science, 2018
Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders and affect approximately (5-10) % of women of reproductive age. Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein, a member of the transforming growth factor-β
Wafa R. AlFatlawi
doaj   +1 more source

The severity of experimental arthritis is independent of IL-36 receptor signaling [PDF]

open access: yes, 2013
Introduction: Interleukin (IL)-36 refers to three related IL-1 family cytokines, IL-36 alpha, IL-36 beta, and IL-36 gamma, that bind to the IL-36 receptor (IL-36R). IL-36 exerts proinflammatory effects in skin and lung and stimulates T cell responses. In
Vigne, Solenne   +26 more
core   +1 more source

Designed DNA-Encoded IL-36 Gamma Acts as a Potent Molecular Adjuvant Enhancing Zika Synthetic DNA Vaccine-Induced Immunity and Protection in a Lethal Challenge Model

open access: yesVaccines, 2019
Identification of novel molecular adjuvants which can boost and enhance vaccine-mediated immunity and provide dose-sparing potential against complex infectious diseases and for immunotherapy in cancer is likely to play a critical role in the next ...
Lumena Louis   +5 more
doaj   +1 more source

Interleukin-36 in Infectious and Inflammatory Skin Diseases

open access: yesFrontiers in Immunology, 2019
Interleukin-36 (IL-36) comprises to a cytokine family consisting of four isoforms IL-36α, IL-36β, IL-36γ, and IL-36 receptor antagonist (IL-36 Ra). These IL-36 cytokines, in turn, belong to the IL-1 superfamily.
Anna-Lena Buhl, Joerg Wenzel
doaj   +1 more source

Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis

open access: yesActa Dermato-Venereologica, 2017
Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. The therapeutic response to biologics supports the pivotal role of the tumour necrosis alpha (TNF-?)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these ...
Kazuhisa Furue   +8 more
doaj   +1 more source

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