Results 11 to 20 of about 5,139,608 (255)

The role of IL-36 and 37 in hepatocellular carcinoma [PDF]

Frontiers in Immunology
Hepatocellular carcinoma (HCC) has garnered considerable attention due to its morbidity and mortality. Although the precise mechanisms underlying HCC tumorigenesis remain to be elucidated, evidence suggests that host immunity plays a pivotal role in its ...
Juan Cao, Juan Cao, Jun-Hong Liu, Jun-Hong Liu, Steven G. Wise, Jingchun Fan, Shisan Bao, Gui-Sen Zheng   +7 more
doaj   +6 more sources

IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic [PDF]

Frontiers in Immunology, 2022
Interleukin (IL)-36 cytokines are members of the IL-1 superfamily, which consists of three agonists (IL-36α, IL-36β and IL-36γ) and an IL-36 receptor antagonist (IL-36Ra). IL-36 cytokines are crucial for immune and inflammatory responses. Abnormal levels
Hongna Dong, Yuqiu Hao, Wei Li, Wei Yang, Peng Gao   +4 more
doaj   +4 more sources

Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review [PDF]

Journal of Inflammation Research
Yuan Xu, Jing-Yan Wang, Yang Zou, Xue-Wei Ma, Tian Meng College of Health Industry, Sichuan Tourism University, Chengdu, Sichuan, 610100, People’s Republic of ChinaCorrespondence: Yuan Xu, Email 230973159@qq.comAbstract: Inflammatory cytokines ...
Xu Y, Wang JY, Zou Y, Ma XW, Meng T
doaj   +4 more sources

IL-17A-driven psoriasis is critically dependent on IL-36 signaling [PDF]

Frontiers in Immunology, 2023
Plaque psoriasis is an autoinflammatory and autoimmune skin disease, affecting 1-3% of the population worldwide. Previously, high levels of IL-36 family cytokines were found in psoriatic skin lesions, thereby contributing to keratinocyte ...
Berenice Fischer, Tanja Kübelbeck, Antonia Kolb, Julia Ringen, Julia Ringen, Ari Waisman, Ari Waisman, Miriam Wittmann, Susanne Karbach, Susanne Karbach, Susanne Karbach, Stephan Marcus Kölsch, Daniela Kramer, Daniela Kramer   +13 more
doaj   +4 more sources

Dichotomous roles of IL-36 and IL-38 in cardiovascular disease [PDF]

Frontiers in Immunology
Members of the interleukin-1 (IL-1) superfamily play crucial roles in orchestrating inflammation and immune responses. Among them, IL-36 and IL-38 have emerged as cytokines with contrasting roles in cardiovascular disease (CVD).
Haifeng Zhang, Wenhui Huang, Shisan Bao
doaj   +4 more sources

IL-36-related genes predict prognosis of gastric cancer [PDF]

Frontiers in Oncology
IntroductionGastric cancer (GC) is one of the most frequently encountered malignant tumors in the clinic. Because effective early screening techniques are lacking, most patients have advanced disease at first diagnosis.
Ying Zhang, Yanbo Liu, Xin Guan, Meng Qu, Dianxiu Wu, Ning Liu, Zhengkun Lin, Yuqi Liu, Han Wang, Lijuan Yang   +9 more
doaj   +4 more sources

IL‐36 cytokines and gut immunity [PDF]

Immunology, 2021
SummaryInterleukin 36 (IL‐36) constitutes a group of cytokines that belong to the IL‐1 superfamily. Emerging evidence has suggested a role of IL‐36 in the pathogenesis of many inflammatory disorders. Intriguingly, in the gastrointestinal tract, IL‐36 has a rather complex function.
Vu L. Ngo, Michal Kuczma, Estera Maxim, Timothy L. Denning   +3 more
openaire   +3 more sources

Influence of serum IL-36 subfamily cytokines on clinical manifestations of asthma [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: The IL-36 subfamily, a member of the IL-1 superfamily, is thought to promote type 2 (T2) and non-T2 inflammation and involved in autoimmune and airway disease progression. However, its role in asthma remains unclear.
Yuki Hoshino, MD, Tomoyuki Soma, MD, PhD, Kazuyuki Nakagome, MD, PhD, Reina Ishii, MD, Tatsuhiko Uno, MD, Kazuki Katayama, MD, Hidetoshi Iemura, MD, Erika Naitou, MD, Takahiro Uchida, MD, PhD, Yoshitaka Uchida, MD, PhD, Hidetoshi Nakamura, MD, PhD, Makoto Nagata, MD, PhD   +11 more
doaj   +4 more sources

Targeting IL-36 in Inflammatory Skin Diseases [PDF]

BioDrugs, 2023
Interleukin (IL)-36 cytokines are members of the IL-1 superfamily of cytokines. IL-36 cytokines are composed of three agonists (IL-36α, IL-36β, and IL-36γ) and two antagonists (IL-36 receptor antagonist [IL36Ra] and IL-38). These work in innate and acquired immunity and are known to contribute to host defense and to the pathogenesis of autoinflammatory
Ryo Fukaura, Masashi Akiyama
openaire   +3 more sources

IL-36 Receptor Antagonist with Special Emphasis on IL-38

International Journal of Immunopathology and Pharmacology, 2013
IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFκB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro.
Y. Shaik, G. Sabatino, G. Maccauro, G. Varvara, G. Murmura, A. Saggini, M. Rosati, F. Conti, E. Cianchetti, CARAFFA, Auro, ANTINOLFI, PIERLUIGI, F. Pandolfi, POTALIVO, GABRIELE, R. Galzio, P. Conti, T. C. Theoharides   +15 more
core   +8 more sources