The regulatory role of IL-37 and IL-38 in CAR-T associated cytokine release syndrome in multiple myeloma [PDF]
Frontiers in ImmunologyMultiple myeloma remains largely incurable despite advances in proteasome inhibitors and monoclonal antibodies. Chimeric antigen receptor (CAR)-T-cell therapy targeting B-cell maturation antigen (BCMA) has achieved deep responses in relapsed/refractory ...
Xiujuan Huang +5 more
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Butyrophilin 3A1 Contributes to Inflammation and Induces a Lupus‐Like Disease by Inhibiting the IL‐38‐Ferroptosis Axis [PDF]
MedCommSystemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin. Recent evidence has linked butyrophilin 3A1 (BTN3A1) to immune dysregulation. This study was to elucidate the relationship of BTN3A1 in SLE. Expression of BTN3A1 in plasma and
Wang‐Dong Xu +9 more
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Recombinant IL-38 Alleviates Temporomandibular Joint Synovial Inflammation via IL-1R1-NF-κB-IL1β Pathway [PDF]
International Dental JournalIntroduction and aims: Interleukin (IL)-38 has been identified as an anti-inflammatory cytokine; however, its specific role in temporomandibular joint (TMJ) synovial inflammation and the identity of its functional receptors remain elusive.
Ping Luo +3 more
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Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review [PDF]
Journal of Inflammation ResearchYuan Xu, Jing-Yan Wang, Yang Zou, Xue-Wei Ma, Tian Meng College of Health Industry, Sichuan Tourism University, Chengdu, Sichuan, 610100, People’s Republic of ChinaCorrespondence: Yuan Xu, Email 230973159@qq.comAbstract: Inflammatory cytokines ...
Xu Y, Wang JY, Zou Y, Ma XW, Meng T
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The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases [PDF]
Frontiers in Pharmacology, 2021 Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a
Miao-miao Han +12 more
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The role of IL-38 in intestinal diseases - its potential as a therapeutic target [PDF]
Frontiers in Immunology, 2022 IL-38, an anti-inflammatory cytokine, is a key regulator of homeostasis in host immunity. Intestinal immunity plays a critical role in defence against pathogenic invasion, as it is the largest surface organ and the most common entry point for micro ...
Qiang Wang +4 more
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IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome [PDF]
Mediators of Inflammation, 2021 Interleukin- (IL-) 38 is an emerging cytokine with multiple functions involved in infection and immunity. However, the potential role of IL-38 in the host immune response during sepsis remains elusive.
Yun Ge +4 more
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IL-38 promotes the development of prostate cancer [PDF]
Frontiers in ImmunologyIntroductionProstate Cancer (PCa) remains a significant concern in male cancer-related mortality. Tumour development is intricately regulated by the complex interactions between tumour cells and their microenvironment, making it essential to determine ...
Huiyan Wu +9 more
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IL-35, IL-37, and IL-38 in acute pancreatitis: proposed immunopathogenic mechanisms and therapeutic potential [PDF]
Frontiers in ImmunologyAcute pancreatitis (AP) is driven by premature enzyme activation, pancreatic tissue injury, and dysregulated immune responses. IL-35 and IL-37 are key anti-inflammatory mediators whose dynamic regulation influences disease severity.
Hailong Yan +6 more
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IL-38 attenuates vascular calcification by upregulating GPX3-mediated antioxidant defense via the PPAR-γ/NRF2 axis [PDF]
Cellular and Molecular Life SciencesVascular calcification is a pathological process commonly associated with cardiovascular diseases, diabetes, and renal insufficiency, driven by inflammation, oxidative stress, and endoplasmic reticulum stress. IL-38, a member of the IL-1 cytokine family,
Lei Zhu +15 more
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