Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
Open MedicineOral cancer constitutes a significant public health challenge, and gaining insights into the pathogenesis of oral cancer is crucial for the development of innovative therapeutic approaches. To address this objective, this study investigates the impact of
Fang Jing +5 more
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Intracellular mature IL-37 suppresses tumor metastasis via inhibiting Rac1 activation
, 2017 IL-37, a newly found anti-inflammatory cytokine of the IL-1 family, has both extracellular and intracellular functions. Accumulating evidences indicate that it is also involved in tumor progression. However, the mechanism and its intracellular target are
Chu, H +31 more
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Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome [PDF]
, 2014 Objective. More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis ...
Kunwu Yu +11 more
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Frontiers in Immunology, 2022 BackgroundIL-37 is a recently identified cytokine with potent immunosuppressive functions. The research fronts of IL-37 are worth investigating, and there is no bibliometric analysis in this field.
Ya-fei Qin +21 more
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IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8 [PDF]
, 2021 Background: Interleukin 37 (IL-37), a member of IL-1 family, broadly suppresses inflammation in many pathological conditions by acting as a dual-function cytokine in that IL-37 signals via the extracellular receptor complex IL1-R5/IL-1R8, but it can also
López Vales, Rubén +9 more
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Deregulation of IL-37 and its miRNAs modulators in sarcopenic patients after rehabilitation
Journal of Translational Medicine, 2021 Background sarcopenia is a highly prevalent condition in elderly individuals which is characterized by loss of muscle mass and functions; recent results showed that it is also associated with inflammation.
Francesca La Rosa +7 more
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IL-37 suppresses inflammatory responses in mycobacterial-infected macrophages and mice.
, 2017 (A- B) ELISA detection of IL-6 (A) and TNF-α (B) in WT and IL-37-Tg macrophages infected with H37Rv at MOI = 5 for indicated times. Results are the mean±SEM and representative of 3 independent experiments with triplicates each. (C-D) Kinetics of IL-6 (C)
Wenxia Peng (3632905) +12 more
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Study of down regulation of IL-37 expression in breast cancer tumoral tissues and its association with grade 3 tumor [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2018 Background and Aim: Nowadays, breast cancer is the most common cancer among women in the world. Considering the high prevalence, identification of diagnostic markers can be useful for early diagnosis and cancer management.
Marzieh Ghafari Farsani +2 more
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Interleukin‐37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway
Journal of Diabetes InvestigationAims/Introduction Diabetic foot ulcer (DFU) is a prevalent complication of diabetes characterized by heightened inflammation and impaired wound‐healing processes. Interleukin‐37 (IL‐37) is a natural suppressor of innate inflammation.
Qiaoli Cui +20 more
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Egyptian Journal of Medical Human Genetics, 2022 Background IL-37 is an anti-inflammatory cytokine that increases in several inflammatory diseases with the main inducing signal for its production being pro-inflammatory cytokines like TNF-α.
Dina Ragab, Ahmed Abbas, Ramy Salem
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