Results 61 to 70 of about 5,184,526 (265)
Deregulation of IL-37 and its miRNAs modulators in sarcopenic patients after rehabilitation
Journal of Translational Medicine, 2021 Background sarcopenia is a highly prevalent condition in elderly individuals which is characterized by loss of muscle mass and functions; recent results showed that it is also associated with inflammation.
Francesca La Rosa +7 more
doaj +1 more source
The role of IL-37 in skin and connective tissue diseases
Biomedicine & Pharmacotherapy, 2020 IL-37 was discovered as an anti-inflammatory and immunosuppressive cytokine of the IL-1 family. Significant advancements in the understanding of signaling pathways associated with IL-37 have been made in recent years. IL-37 binds to IL-18R and recruits IL-1R8 to form the IL-37/IL-1R8/IL-18Rα complex.
Yu, Pan +6 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook +6 more
wiley +1 more source
, 2017 Interleukin-37 (IL-37), a novel member of the IL-1 family, plays fundamental immunosuppressive roles by broadly reducing both innate inflammation and acquired immunity, but whether it is involved in the pathogenesis of tuberculosis (TB) has not been ...
Siyu Liu +25 more
core +1 more source
Study of down regulation of IL-37 expression in breast cancer tumoral tissues and its association with grade 3 tumor [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2018 Background and Aim: Nowadays, breast cancer is the most common cancer among women in the world. Considering the high prevalence, identification of diagnostic markers can be useful for early diagnosis and cancer management.
Marzieh Ghafari Farsani +2 more
doaj
Characteristics and Functions of IL-37
International Journal of BiomedicineInterleukin-37 (IL-37), previously known as IL-1F7, is a member of the IL-1 family of cytokines. There are five basic subtypes of IL-37, including IL-37a, IL-37b, IL-37c, IL-37d, and IL-37e. Like other members of the IL-1 family, IL-37 is initially expressed as an immature precursor protein that needs to be processed enzymatically by caspase-1 to ...
Fang Yang +7 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters +17 more
wiley +1 more source
Suppression of inflammation and acquired immunity by IL-37
, 2018 IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli.
Dinarello C. A., Cavalli G.
core +2 more sources
Interleukin‐37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway
Journal of Diabetes InvestigationAims/Introduction Diabetic foot ulcer (DFU) is a prevalent complication of diabetes characterized by heightened inflammation and impaired wound‐healing processes. Interleukin‐37 (IL‐37) is a natural suppressor of innate inflammation.
Qiaoli Cui +20 more
doaj +1 more source
Egyptian Journal of Medical Human Genetics, 2022 Background IL-37 is an anti-inflammatory cytokine that increases in several inflammatory diseases with the main inducing signal for its production being pro-inflammatory cytokines like TNF-α.
Dina Ragab, Ahmed Abbas, Ramy Salem
doaj +1 more source