Results 81 to 90 of about 5,184,526 (265)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Study of Serum IgM, IgG, IL-37 Levels and IL-37 Gene Polymorphism in Women Infected with Trichomonas Vaginalis in Baqubah City

Proceedings of the International Conference on Applied Innovations in IT
Trichomoniasis is the most prevalent non-viral sexually transmitted infection globally, relying on both innate and adaptive immunity to combat the extracellular pathogen Trichomonas vaginalis. This study included 45 infected women and 45 healthy controls
Noor Ghassan, Maha Falih Nazzal, Ibtisam Badday Hassan   +2 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Increased expression of IL-37 in patients with Graves' disease and its contribution to suppression of proinflammatory cytokines production in peripheral blood mononuclear cells. [PDF]

PLoS ONE, 2014
BACKGROUND: Interleukin-37 (IL-37), a member of IL-1 family, is primarily an anti-inflammatory cytokine, which reduces systemic and local inflammation. However, the expression and role of IL-37 in Graves' disease (GD) remains unknown.
Yanqun Li, Zi Wang, Ting Yu, Bingni Chen, Jinshun Zhang, Kunzhao Huang, Zhong Huang   +6 more
doaj   +1 more source

IL-37 diminishes proteoglycan loss in human OA cartilage: donor-specific link between IL-37 and MMP-3 [PDF]

Osteoarthritis and Cartilage, 2019
A hallmark of osteoarthritis (OA) is degradation of articular cartilage proteoglycans. In isolated human OA chondrocytes, the anti-inflammatory cytokine Interleukin-37 (IL-37) lowers the expression of the proteolytic MMP and ADAMTS enzymes, which mediate this degradation. Therefore, we investigated if IL-37 protects against proteoglycan loss in freshly
E.W. van Geffen, A.P.M. van Caam, W. Schreurs, F.A. van de Loo, P.L.E.M. van Lent, M.I. Koenders, C.S. Thudium, A.C. Bay-Jensen, E.N. Blaney Davidson, P.M. van der Kraan   +9 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Counteractive Effects of IL-33 and IL-37 on Inflammation in Osteoarthritis †

, 2022
Osteoarthritis (OA) is a chronic inflammatory disease where pro-inflammatory cytokines, damage-associated molecular patterns (DAMPs), and macrophages play a crucial role.
Vikrant Rai, Farial Samadi, Dilisio, Matthew F., Agrawal, Devendra K., Rai, Vikrant, Samadi, Farial, Matthew F. Dilisio, Devendra K. Agrawal   +7 more
core   +1 more source

The amelioration effect of antidiabetic agents on cytokine expression in patients with type 2 diabetes mellitus

Saudi Pharmaceutical Journal
Inflammation is a condition that is closely linked to diabetes mellitus type 2 (T2DM), short for T2DM several different antidiabetic medications have been produced to regulate hyperglycemia, with indications that these therapies may have anti ...
Abeer M. Abd El-Hameed, Areej A. Eskandrani, Eman Salah Abdel-Reheim, Adel Abdel Moneim, Wessam Addaleel   +4 more
doaj   +1 more source

Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37

Frontiers in Microbiology, 2015
The effect of the anti-inflammatory cytokine interleukin-37 (IL 37) on host defense against Candida infections remains unknown. We assessed the role of IL 37 in a murine model of disseminated candidiasis using mice transgenic for human IL 37 (hIL 37Tg).
Frank L. Van De Veerdonk, Frank L. Van De Veerdonk, Frank L. Van De Veerdonk, Mark S Gresnigt, Jos WM Van Der Meer, Leo eJoosten, Leo eJoosten, Mihai eNetea, Mihai eNetea, Charles eDinarello, Charles eDinarello   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source