Results 51 to 60 of about 5,184,526 (265)

Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus

Frontiers in Microbiology, 2022
The COVID-19 pandemic involved millions of people and diabetes was identified as an associated comorbidity. Initiation of systemic corticosteroids in patients suffering from severe COVID-19 was associated with lower mortality.
Sima Tokajian, Georgi Merhi, Charbel Al Khoury, Georges Nemer, Georges Nemer   +4 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Intracellular mature IL-37 suppresses tumor metastasis via inhibiting Rac1 activation

, 2017
IL-37, a newly found anti-inflammatory cytokine of the IL-1 family, has both extracellular and intracellular functions. Accumulating evidences indicate that it is also involved in tumor progression. However, the mechanism and its intracellular target are
Chu, H, Guo, C, W Zhao, Zhu, F, J Wang, Chen, X, Chen, W, W Chen, Wang, J, Zhao, W, Wang, Q, Shi, Y, Wang, X, L Zhang, F Zhu, Koussatidjoa, S, Y Li, W Li, Y Jia, Zhao, M, S Koussatidjoa, Q Wang, Li, Y, Y Shi, Jia, Y, Li, W, Zhang, L, C Guo, X Chen, M Zhao, X Wang, H Chu   +31 more
core   +1 more source

Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3

Open Medicine
Oral cancer constitutes a significant public health challenge, and gaining insights into the pathogenesis of oral cancer is crucial for the development of innovative therapeutic approaches. To address this objective, this study investigates the impact of
Fang Jing, Li Kunshan, Zhang Liyuan, Zhang Ying, Wang Yifan, Zhang Jing   +5 more
doaj   +1 more source

The intellectual base and research fronts of IL-37: A bibliometric review of the literature from WoSCC

Frontiers in Immunology, 2022
BackgroundIL-37 is a recently identified cytokine with potent immunosuppressive functions. The research fronts of IL-37 are worth investigating, and there is no bibliometric analysis in this field.
Ya-fei Qin, Ya-fei Qin, Shao-hua Ren, Shao-hua Ren, Bo Shao, Bo Shao, Hong Qin, Hong Qin, Hong-da Wang, Hong-da Wang, Guang-ming Li, Guang-ming Li, Yang-lin Zhu, Yang-lin Zhu, Cheng-lu Sun, Cheng-lu Sun, Chuan Li, Chuan Li, Jing-yi Zhang, Jing-yi Zhang, Hao Wang, Hao Wang   +21 more
doaj   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

IL-37 suppresses inflammatory responses in mycobacterial-infected macrophages and mice.

, 2017
(A- B) ELISA detection of IL-6 (A) and TNF-α (B) in WT and IL-37-Tg macrophages infected with H37Rv at MOI = 5 for indicated times. Results are the mean±SEM and representative of 3 independent experiments with triplicates each. (C-D) Kinetics of IL-6 (C)
Wenxia Peng (3632905), Peng Wang (34436), Hua Yang (120668), Wenjuan Bai (2162179), Haipeng Liu (218254), Qun Ji (3632908), Hao Chen (5190), Xin He (48101), Ruijuan Zheng (281946), Siyu Liu (825600), Jianxia Chen (281945), Baoxue Ge (281952), Zhonghua Liu (148625)   +12 more
core   +1 more source

IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8 [PDF]

, 2021
Background: Interleukin 37 (IL-37), a member of IL-1 family, broadly suppresses inflammation in many pathological conditions by acting as a dual-function cytokine in that IL-37 signals via the extracellular receptor complex IL1-R5/IL-1R8, but it can also
López Vales, Rubén, Eisenmesser, Elan Z., Charabati, Marc, Sánchez Fernández, Alba, Prat, Alexandre, Amo Aparicio, Jesús, Zandee, Stephanie, Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia, Garlanda, Cecilia, Dinarello, Charles A.   +9 more
core   +1 more source